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ClinicalTrials.gov public records Last synced Nov 14, 2026, 7:49 PM EST

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Showing 49–72 of 178 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lower Limb Amputation Clear all

Conditions: Amputation Stump, Amputation, Amputees, Lower Limb Deformity, Prosthesis User, Prosthesis
Interventions: Moisture Management Liner; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Holliston, Massachusetts

Conditions: Amputation of Lower Limb
Interventions: Prosthetic foot, Physical therapy; Other
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Foot Ulcer, Diabetic
Interventions: NEOX® CORD 1K, Standard of Care (Pressure Bandage); Other · Procedure
Lead sponsor: Amniox Medical, Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 3
States / cities: Tucson, Arizona • Castro Valley, California • Newnan, Georgia

Conditions: Amputation; Traumatic, Leg, Lower
Interventions: Phase 2 Prescribed Prosthesis, Phase 2 Robotic Prosthetic Leg, Phase 3 No Prosthesis, Phase 3 Robotic Prosthetic Leg, Phase 3 Prescribed Prosthesis; Other
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Lower Limb Amputation Below Knee
Interventions: Fixed stiffness prosthesis, Automatic stiffness prosthesis; Device
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 79 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Amputation
Interventions: Prosthetic socket fit testing system; Device
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 70 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis, Skin Ulcer, Leg Ulcer, Pyoderma, Peripheral Arterial Disease, Lymphedema, Surgical Complication, Venous Leg Ulcers (VLUs), Calciphylaxis, Sickle Cell Ulcer, Pressure Ulcer (PU), Diabetic Foot Ulcers (DFUs), Pressure Injury, Arterial Ulcers, Soft Tissue Radionecrosis (STRN), Traumatic Wounds, Chronic Ulcer
Interventions: Usual care; Other
Lead sponsor: U.S. Wound Registry; Other
Eligibility: Not listed
Enrollment: 300,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2030
U.S. locations: 1
States / cities: The Woodlands, Texas

Conditions: Amputation, Prosthesis User
Interventions: Standard-of-care prosthetic foot, Standard-of-care prosthetic foot with heel-stiffening wedge, Standard-of-care prosthetic foot of one category greater stiffness, Dual keel prosthetic foot, Powered ankle-foot; Device
Lead sponsor: VA Puget Sound Health Care System; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Diabetic Ulcers on Both Feet, Amputation; Traumatic, Limb, Sexual Dysfunction, Diabetic Foot Ulcer Ischemic
Interventions: Diabetes education; Behavioral
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Amputation; Traumatic, Leg, Lower
Interventions: Tap dance program; Other
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Lower Extremity Amputation
Interventions: Coached group, Self-directed control group, Screened only; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 69 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Stroke, Parkinson Disease, Lower Limb Amputation Knee, Fall Injury, Fall Patients, Falling
Interventions: Airbag Belt Fall Protection System; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 85 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Amputation; Traumatic, Leg, Lower
Interventions: OPRA; Device
Lead sponsor: Walter Reed National Military Medical Center; Federal
Eligibility: 22 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 2
States / cities: Bethesda, Maryland • Philadelphia, Pennsylvania

Conditions: Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions: Power Knee; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Holliston, Massachusetts • Austin, Texas

Conditions: Traumatic Amputation of Lower Extremity
Interventions: Not listed
Lead sponsor: Major Extremity Trauma Research Consortium; Other
Eligibility: 18 Years to 60 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 10
States / cities: San Francisco, California • Tampa, Florida • Baltimore, Maryland + 7 more

Conditions: Amputation
Interventions: Powered knee and ankle prosthesis; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 80 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Amputation, Physical Activity
Interventions: Weekly exercise sessions with physical therapist and psychologist, Home-based exercises; Behavioral
Lead sponsor: Rosalind Franklin University of Medicine and Science; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 2
States / cities: North Chicago, Illinois

Conditions: Amputation, Phantom Limb Pain, Hoffman's Reflex
Interventions: Transcutaneous spinal cord stimulation; Device
Lead sponsor: University of Pittsburgh; Other
Eligibility: 21 Years to 70 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Amputation, Amputation, Traumatic, Amputation; Traumatic, Leg, Lower
Interventions: Compliant Adaptive Energy Storage and Return Foot, AllPro; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions: Database Entry; Other
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: Up to 99 Years
Enrollment: 250 participants
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Diabetic Foot Ulcer Outcome, Quality of Patient Care
Interventions: cellular and tissue based therapy, negative pressure wound therapy, debridement, advanced wound therapy, Nutritional screening, off-loading, Hyperbaric oxygen Therapy; Biological · Device · Procedure + 1 more
Lead sponsor: U.S. Wound Registry; Other
Eligibility: Not listed
Enrollment: 10,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2025
U.S. locations: 1
States / cities: The Woodlands, Texas

Conditions: Transfemoral Amputation
Interventions: RISE guided personalization of prosthetic legs by tuning experts, RISE guided personalization of prosthetic legs by prosthetists, Manual personalization of the prosthetic leg by tuning experts; Device
Lead sponsor: North Carolina State University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions: Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator; Procedure
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Diabetes, Foot Ulcer
Interventions: Tailored Intervention (TI), Current Practice (CP); Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years and older
Enrollment: 241 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Moisture Management Liner At-Home Evaluation

Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss

NEOX® CORD 1K vs Standard of Care in Non-healing Diabetic Foot Ulcers

Design, Prototyping, and Testing of a Robotic Prosthetic Leg

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance in the Real World

Prosthetic Socket Fit Testing System

A Real-World Registry of Chronic Wounds and Ulcers

Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads

The Impact of Sexual Health and Amputation Focused Education on Regulation of Glucose and Amputation Prevention

Tap Dance for Adults With Lower Limb Amputation

Weight Loss Intervention for Individuals With Lower Extremity Amputation

Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk

Transtibial Osseointegration

Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees

Prosthetic Fit Assessment in Transtibial Amputees Secondary to Trauma

Adaptive Recalibration of Prosthetic Leg Neural Control System

Targeting Balance Confidence to Increase Community Integration in Users of Prostheses

Neuromodulation in Lower Limb Amputees

No Power Bionic Lower Extremity Prosthesis

C-STAR Movement Database

The Diabetic Foot Ulcer Registry

Towards Efficient Personalization of Computerized Lower Limb Prostheses Via Reinforcement Learning in a Clinical Setup - Group 1

The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD

STEP UP to Avert Amputation in Diabetes