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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:13 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 178 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lower Limb Amputation Clear all

Conditions: Amputation
Interventions: Fillauer Slope Adaptive Foot, Fillauer Motion Foot SLX; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: Release/Relock Socket - In Lab, Release/Relock Socket - Out of Lab, Release/Relock Socket & Control; Device
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Diabetic Foot Ulcer
Interventions: Not listed
Lead sponsor: Boise VA Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Boise, Idaho

Conditions: Amputation
Interventions: emPOWER Ankle, Subject's own passive prosthesis; Device
Lead sponsor: Otto Bock Healthcare Products GmbH; Industry
Eligibility: 55 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Amputation
Interventions: Hybrid Leg, Prescribed Passive Prosthesis; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 95 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Lower Limb Amputation
Interventions: Conventional Prosthetic Transfemoral Socket System, Novel Prosthetic transfemoral socket system; Device
Lead sponsor: Ohio Willow Wood; Industry
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 2
States / cities: Columbus, Ohio • Mount Sterling, Ohio

Conditions: Amputation, Lower Limb
Interventions: 3D motion capture, wearable devices, and functional outcome measures; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Amputation
Interventions: Passive-elastic prosthetic foot, Powered ankle-foot prosthesis; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 67 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Lower Extremity Amputation
Interventions: Investigational prosthetic foot; Device
Lead sponsor: University of Washington; Other
Eligibility: 16 Years to 85 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Critical Limb Ischemia, Critical Lower Limb Ischemia, Peripheral Artery Disease, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia, Arterial Occlusive Diseases, Arterial Occlusion, Arterial Disease, Peripheral Artery Occlusion, Peripheral Vascular Disease, Peripheral Ischemia, Vascular Diseases
Interventions: LimFlow System; Device
Lead sponsor: LimFlow, Inc.; Industry
Eligibility: 18 Years to 95 Years
Enrollment: 105 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 20
States / cities: San Francisco, California • Torrance, California • New Haven, Connecticut + 15 more

Conditions: Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Above Knee
Interventions: Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo; Device
Lead sponsor: Hanger Institute for Clinical Research and Education, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Amputation, Amputation; Traumatic, Limb, Amputation, Traumatic
Interventions: Low cost lower limb prosthetic socket; Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 95 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Trauma Injury
Interventions: Lower Extremity Amputation; Procedure
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Amputation
Interventions: META-Arc foot locked, META-Arc foot unlocked; Device
Lead sponsor: University of Washington; Other
Eligibility: 16 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Tampa, Florida • Mount Sterling, Ohio • Seattle, Washington

Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: Not listed
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Foot Ulcers, Osteomyelitis, Amputation
Interventions: Not listed
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 2
States / cities: Dallas, Texas

Conditions: Amputation
Interventions: Vacuum assisted socket technology (Harmony System, Otto Bock Healthcare); Device
Lead sponsor: Stony Brook University; Other
Eligibility: 21 Years to 75 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 2
States / cities: Stony Brook, New York • West Babylon, New York

Conditions: Amputation
Interventions: Stimulating nerve electrodes and intramuscular recording electrodes; Device
Lead sponsor: Louis Stokes VA Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Phantom Limb Pain
Interventions: Lower extremity amputation; Procedure
Lead sponsor: North Texas Veterans Healthcare System; Federal
Eligibility: 18 Years and older
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Lower Limb Amputation
Interventions: Active vacuum test prosthesis; Device
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Lower Extremity Amputation, Trans-Tibial Amputation, Traumatic Lower Extremity Amputation, Agonist-Antagonist Myoneural Interface
Interventions: Modified Amputation, Standard Amputation; Procedure
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Amputation
Interventions: Not listed
Lead sponsor: Össur Iceland ehf; Industry
Eligibility: 18 Years and older
Enrollment: 2,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2033
U.S. locations: 1
States / cities: Irvine, California

Conditions: Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
Interventions: Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension, Total surface bearing suction socket with a sleeve suspension, Vacuum-assisted socket system (Harmony System, Otto Bock); Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Lower Limb Amputation Above Knee (Injury), Congenital Amputation of Lower Limb, Lower Limb Amputation Knee
Interventions: Kenevo or C-Leg 4, Non microprocessor controlled knee (NMPK); Device
Lead sponsor: Otto Bock Healthcare Products GmbH; Industry
Eligibility: 65 Years and older
Enrollment: 107 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 90
States / cities: Dothan, Alabama • Gilbert, Arizona • Phoenix, Arizona + 85 more

Search by objective public record fields.

Influence Of A Slope Adaptive Foot On Participation Of Veterans With Lower-Limb Amputations

NIH Release/Relock Socket

Prevention of Amputation in Diabetic Foot Ulcers Using Amniotic Tissue

EmPOWERing Active Seniors With Energy

Intuitive Control of a Hybrid Prosthetic Leg During Ambulation

Evaluation of a Novel Transfemoral Prosthetic Socket System

Reliability and Validity of Continuous Inter-limb Stability

Does Walking Performance Improve When Veterans With Leg Amputations Are Given Visual Feedback?

Community Walking Trials: Comparing Prosthetic Feet

PROMISE II: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

Low Cost Socket for Lower Limb Amputees

ICG Fluorescence Imaging in Lower Extremity Amputation Patients

Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis

Influence of Socket Volume on Prosthesis Performance

Investigation of the Use of Hyperspectral Imaging in Foot Surgery Patients

Effect of Socket Wall Height With Vacuum Suspension for Above Knee Amputees

Feasibility of Neural Feedback for Lower Limb Amputees

Incidence of Phantom Limb Pain and Method of Anesthesia After Lower Extremity Amputation

Development of Adaptive Vacuum Suspension to Improve Prosthetic Fit and Residual Limb Health

Kinematics of Ewing Amputees

Pro APP Prosthetic Outcome Registry

Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking

Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population