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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:02 AM EST

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Showing 97–120 of 178 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lower Limb Amputation Clear all

Conditions: Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Interventions: Questionnaire; Other
Lead sponsor: Minneapolis Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Transfemoral Amputation, Unilateral Traumatic Amputation of Leg at or Above Knee
Interventions: C leg compared to subject's mechanical leg (Otto Bock); Device
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 80 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2019
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Lower-Limb Amputation
Interventions: Powered and passive lower limb prosthesis and control; Device
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2032
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Critical Limb Ischemia
Interventions: BMAC injection, Placebo injection; Device
Lead sponsor: Harvest Technologies; Industry
Eligibility: 18 Years and older
Enrollment: 97 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 34
States / cities: Birmingham, Alabama • El Dorado, Arkansas • Los Angeles, California + 30 more

Conditions: Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
Interventions: ACTIVE cryoneurolysis, SHAM cryoneurolysis; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Diabetes Mellitus, Critical Limb Ischemia, Lower Limb Amputation Knee, Peripheral Arterial Disease
Interventions: Active Arm N-acetyl cysteine (NAC), Placebo Arm; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 30 Years to 90 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Amputation; Postoperative, Sequelae
Interventions: Hyperbaric Oxygen; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions: Caesar Foot; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Austin, Texas

Conditions: People With Lower Limb Amputation That Are Ambulatory
Interventions: Assessed for socket fit; Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older · Female only
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Other and Unspecified Complications of Amputation Stump
Interventions: Otto Bock C-Leg, Otto Bock Genium; Device
Lead sponsor: Jason Highsmith; Other
Eligibility: 18 Years to 85 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Neuroma, Neuroma Amputation, Neuroma of Upper Limb, Neuroma of Lower Limb
Interventions: Indocyanine green; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Lower Extremity Amputation
Interventions: Caregiver socket, Prosthetist socket; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Traumatic Amputation of Lower Extremity
Interventions: Treadmill Training; Other
Lead sponsor: Stony Brook University; Other
Eligibility: 21 Years to 70 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Lower Limb Amputation Above Knee (Injury)
Interventions: Microprocessor Knee (MPK), Non-Microprocessor Knee (NMPK); Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 55 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Amputation, Prosthesis User
Interventions: Qualitative focus group interviews, Qualitative semi-structured interviews; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Amputation
Interventions: Unrectified prosthetic socket, Rectified prosthetic socket; Device
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2005
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Transtibial Amputation
Interventions: Virtual Reality Gait Training, Treadmill Gait Training; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Diabetes Mellitus, Leg Injuries, Traumatic Amputation
Interventions: Transverse plane rotation adaptor pylon, Rigid pylon; Device
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Amputation, Diabetes, Leg Injuries, Traumatic Amputations
Interventions: Total Surface Bearing Suction Socket, Vacuum assisted socket system; Device
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Amputation
Interventions: Clinical Descriptive Measures related to amputation collected, GPS device education/distributed, activPAL device education/distributed, Questionnaire Assessments completed; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Amputation
Interventions: massage; Other
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Amputation
Interventions: Needs-based intervention (physical, psychological, or both); Other
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 89 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 3
States / cities: Chicago, Illinois • Bethesda, Maryland • Minneapolis, Minnesota

Conditions: Transtibial Amputation, Peripheral Artery Disease, Diabetes Mellitus
Interventions: Error-augmentation gait training, Error-correction gait training, Supervised walking; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 40 Years to 89 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 2
States / cities: Aurora, Colorado • Richmond, Virginia

Conditions: Phantom Pain Following Amputation of Lower Limb, Amputation
Interventions: Active Virtual Reality Treatment; Behavioral
Lead sponsor: Albert Einstein Healthcare Network; Other
Eligibility: 18 Years to 100 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 3
States / cities: Philadelphia, Pennsylvania • Seattle, Washington

Search by objective public record fields.

Women's-Specific Footwear With Prosthetic Feet

Functional Outcomes in Dysvascular Transfemoral Amputees

Motorized Prostheses for Lower-limb Amputees

Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI)

Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation

N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes

Hyperbaric Oxygen and Outcome After Below Knee Amputations

Caesar Foot Take-Home Validation Testing

Assessment of Socket Shapes Made by Central Fabrication Facilities

Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis

Evaluation of Neuroma Perfusion with Indocyanine Green Fluorescence Angiography

Improving Prosthetic Provision in Rural Communities: Limb Scanning With Caregiver Assistance

Treadmill Training With Lower Extremity Amputees

Comparative Effectiveness Between Microprocessor Knees and Non-Microprocessor Knees

Shared Decision Making Aid for Prosthetic Design

Prosthetic Limbs After Leg Amputation: Alternative Method of Socket Design

Virtual Reality Rehabilitation for Individuals With Lower Limb Amputation

Prosthetic Components and Stability in Amputee Gait

Vacuum Suspension: Effects on Tissue Oxygenation, Activity and Fit

Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation

Massage on Pain Levels, Range of Motion, and Muscle Strength in Unilateral Lower Limb Amputees

Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users

Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation

Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment