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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:17 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 178 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lower Limb Amputation Clear all

Conditions: Amputation; Lower Extremity, Pain, Persistent Postsurgical
Interventions: Surgical Implantation; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Amputation
Interventions: Multiaxial Prosthetic Foot Emulator, Commercially available prosthetic feet; Device
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 89 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Seattle, Washington

Conditions: Lower Limb Loss
Interventions: Not listed
Lead sponsor: Miami VA Healthcare System; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Trans-tibial Limb Loss
Interventions: Prosthetic alignment perturbation; Procedure
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: Adjustable socket; Device
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Acquired Absence of Lower Limb, Scar Condition and Fibrosis of the Skin
Interventions: Fractional CO2 Laser Ablative Resurfacing; Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Miami, Florida • Tampa, Florida

Conditions: Lower Limb Amputation Below Knee (Injury), Diurnal Residual Limb Fluid Volume Fluctuation
Interventions: Auto Adjusting Prosthesis; Device
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Diabetic Foot Ulcer
Interventions: No intervention-retrospective study; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 89 Years
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Amputation
Interventions: Modified amputation procedure; Procedure
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 2
States / cities: Boston, Massachusetts • Cambridge, Massachusetts

Conditions: Amputation
Interventions: Not listed
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 1,572 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 2
States / cities: Miami, Florida • Seattle, Washington

Conditions: Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
Interventions: ALDH-br bone marrow cells vs. mononuclear bone marrow cells; Procedure
Lead sponsor: Aldagen; Industry
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 5
States / cities: Birmingham, Alabama • Atlanta, Georgia • Indianapolis, Indiana + 2 more

Conditions: Amputation, Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation at Ankle (Injury), Lower Limb Amputation Knee, Lower Limb Amputation at Hip (Injury)
Interventions: Flat terrain locomotor training, Uneven terrain locomotor training; Other
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss, Amputation, Traumatic/Surgery, Cryo Analgesia
Interventions: cryoablation; Device
Lead sponsor: AtriCure, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 2,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2035
U.S. locations: 9
States / cities: Jacksonville, Florida • Pittsfield, Massachusetts • Manchester, New Hampshire + 5 more

Conditions: Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions: ICE Condition, Sham Condition; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Holliston, Massachusetts • Minneapolis, Minnesota

Conditions: Amputation
Interventions: Not listed
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Not listed
Enrollment: 324 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Mastectomy, Upper Limb Amputation Below Elbow, Upper Limb Amputation Above Elbow, Lower Limb Amputation Below Knee, Lower Limb Amputation Above Knee, Knee Arthropathy, Shoulder Arthroplasty, Rotator Cuff Repair, Video-Assisted Thoracoscopic Surgery (VATS), Skin Grafting
Interventions: Cryoneurolysis (active), Sham cryoneurolysis procedure; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: San Diego, California

Conditions: Amputation
Interventions: Not listed
Lead sponsor: University of South Florida; Other
Eligibility: 21 Years to 65 Years
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Infections, Infected Wound, Nonunion of Fracture, Injury Leg, Amputation, Internal Fixation; Complications, Infection or Inflammation, Fracture, Lower Extremity Fracture, Antibiotic Side Effect
Interventions: Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics; Drug
Lead sponsor: Major Extremity Trauma Research Consortium; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 13
States / cities: Indianapolis, Indiana • Baltimore, Maryland • Minneapolis, Minnesota + 9 more

Conditions: Lower Limb Amputation, Drop Foot
Interventions: Lower limb prostheses, Orthoses for Drop-foot; Device
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Peripheral Vascular Disease
Interventions: Ecraprost in lipid emulsion; Drug
Lead sponsor: Tanabe Pharma Corporation; Industry
Eligibility: 40 Years and older
Enrollment: 280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2005
U.S. locations: 15
States / cities: Phoenix, Arizona • Tucson, Arizona • Glendale, California + 12 more

Conditions: Peripheral Vascular Disease
Interventions: Ecraprost in lipid emulsion; Drug
Lead sponsor: Tanabe Pharma Corporation; Industry
Eligibility: 40 Years and older
Enrollment: 560 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2004
U.S. locations: 20
States / cities: Phoenix, Arizona • Tucson, Arizona • Glendale, California + 17 more

Conditions: Amputation, Diabetes
Interventions: shock-absorbing prosthesis; Device
Lead sponsor: University of Utah; Other
Eligibility: 19 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Diabetic Foot Infection, Diabetic Foot
Interventions: Topical Pravibismane, Standard of Care; Drug · Other
Lead sponsor: Microbion Corporation; Industry
Eligibility: 18 Years to 79 Years
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 7
States / cities: Fresno, California • Dallas, Texas • McAllen, Texas + 1 more

Conditions: Traumatic Amputation of Lower Extremity
Interventions: Specialized Functional Prosthetic Training; Other
Lead sponsor: Miami VA Healthcare System; Federal
Eligibility: 40 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Miami, Florida

Search by objective public record fields.

Altius Peripheral Nerve Stimulation in Amputees After TMR/RPNI

A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations

Musculoskeletal Measurements in Transfemoral Amputees

Physiologic Range of Step-by-step Variations in Lower Limb Prosthesis Forces During Walking

Auto Control of Volume Management for Limb Loss

LASER Pilot Project

An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation

The Effect of Implementing a Limb Loss Prevention Program on Amputation Rates

Somatotopic Configuration of Distal Residual Limb Tissues in Lower Extremity Amputations

A Client-Based Outcome System for Individuals With Lower Limb Amputation

ALD-301 for Critical Limb Ischemia, Randomized Trial

Prosthetic Performance Enhancement Trial

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

Socket Cooling Effectiveness Take Home Study

Understanding Prosthetic Needs and Outcomes in Women Veterans With Amputation

Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study

Comparison of Prosthetic Knee Performance During Sitting and Standing

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

Evaluating Mobility Interventions in the Real World

Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease

Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease

Thermoregulation in Individuals With a Leg Amputation

Multi-center Study to Assess Safety, Tolerability and Efficacy of Topical Pravibismane in Moderate DFI Patients

A Comparison of External Mechanical Work Between Different Prosthetic Feet