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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:50 AM EST

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Showing 145–168 of 178 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lower Limb Amputation Clear all
Not listed Not applicable Interventional

Vibrotactile Stimulation With Saphenus Device

NCT05961072
View directory record Official record
Conditions
Amputation
Interventions
Vibrotactile sensory feedback device
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Nov 15, 2026, 5:50 AM EST
Completed Not applicable Interventional

A Test-Drive Strategy for the Prescription of Prosthetic Feet for People With Leg Amputations

NCT03651830
View directory record Official record
Conditions
Amputation
Interventions
Prosthetic Foot Emulator, Commercially available prosthetic feet
Device
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 89 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
3
States / cities
Minneapolis, Minnesota • San Antonio, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Nov 15, 2026, 5:50 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs

NCT06138977
View directory record Official record
Conditions
Amputation
Interventions
Powered prosthesis
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Nov 15, 2026, 5:50 AM EST
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Criteria for Advanced Prosthetic Foot Prescription

NCT03505983
View directory record Official record
Conditions
Prosthesis User, Amputation; Traumatic, Limb, Lower
Interventions
ESR Prosthetic Foot First, Articulating ESR Prosthetic Foot First, Powered Prosthetic Foot First
Device
Lead sponsor
VA New York Harbor Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Nov 15, 2026, 5:50 AM EST
Recruiting Not applicable Interventional

Quantifying Bone and Skin Movement in the Residual Limb of Individuals With Transtibial Amputation Using Dynamic Stereo X-Ray

NCT05287646
View directory record Official record
Conditions
Amputation, Lower Limb
Interventions
Suction Suspension First, Elevated Vacuum Suspension First
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Nov 15, 2026, 5:50 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Moisture Management Liner Effectiveness Study

NCT04427007
View directory record Official record
Conditions
Amputation Stumps, Amputees, Amputation, Lower Limb Deformities, Congenital, Prosthesis User, Prosthesis
Interventions
Moisture Management Liner, Control Liner
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 11, 2025 · Synced Nov 15, 2026, 5:50 AM EST
Completed Not applicable Interventional Results available

Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot

NCT04239222
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
Interventions
Revo-M, Taleo, Proflex XC
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
4
States / cities
Mesa, Arizona • Linthicum, Maryland • Dayton, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2024 · Synced Nov 15, 2026, 5:50 AM EST
Completed Not applicable Interventional

e-OPRA Implant System for Lower Limb Amputees

NCT03720171
View directory record Official record
Conditions
Amputation
Interventions
e-OPRA Implant System
Device
Lead sponsor
Integrum
Industry
Eligibility
22 Years to 65 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Nov 15, 2026, 5:50 AM EST
Recruiting Not applicable Interventional

LIMBER UniLeg: Rapid, On-demand, and Scaled-up Manufacturing of Customized Transtibial Prosthetic Legs for Amputees

NCT06648798
View directory record Official record
Conditions
Amputation of Lower Limb, Prosthesis, Non-inferiority Trial of Prothesis
Interventions
Limber Limb
Device
Lead sponsor
LIMBER Prosthetics & Orthotics Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Nov 15, 2026, 5:50 AM EST
Recruiting Not applicable Interventional

Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees

NCT06194838
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions
Ossur Power Knee, Reboocon Intuy Knee
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Nov 15, 2026, 5:50 AM EST
Completed Phase 3 Interventional Results available

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

NCT02504216
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Rivaroxaban (Xarelto, BAY59-7939), Rivaroxaban-Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
50 Years and older
Enrollment
6,564 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
105
States / cities
Alexander City, Alabama • Birmingham, Alabama • Fort Payne, Alabama + 91 more
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Nov 15, 2026, 5:50 AM EST
Completed Not applicable Interventional

Impact of a Lower Extremity Amputation Pathway Protocol in Dysvascular Patients

NCT03592316
View directory record Official record
Conditions
Lower Extremity Amputation
Interventions
Lower Extremity Amputation Pathway
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2021 · Synced Nov 15, 2026, 5:50 AM EST
Not listed Phase 1 Interventional

Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation

NCT00388752
View directory record Official record
Conditions
Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
Interventions
Acupuncture
Procedure
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 6, 2007 · Synced Nov 15, 2026, 5:50 AM EST
Completed Not applicable Interventional

Online Wound Electronic Medical Record (OWEMR) to Decrease Amputations in Diabetics

NCT01371318
View directory record Official record
Conditions
Wounds, Diabetes Complications, Diabetic Foot, Foot Ulcer
Interventions
Online Wound Electronic Medical Record
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
1,609 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
13
States / cities
Phoenix, Arizona • Tuscon, Arizona • Pomona, California + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 31, 2014 · Synced Nov 15, 2026, 5:50 AM EST
Not listed Not applicable Interventional

External Compression Therapy for Secondary Prevention of Lower-Limb Loss and Cardiovascular Mortality

NCT02054416
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
ArtAssist© Device
Device
Lead sponsor
Temple University
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 8, 2016 · Synced Nov 15, 2026, 5:50 AM EST
Completed Not applicable Interventional

Comparative Effectiveness of Socket Casting Methods: Improving Form and Fit

NCT04141748
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
Symphonie Aqua SystemTM, Hand Casting
Device · Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Chicago, Illinois • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Nov 15, 2026, 5:50 AM EST
Withdrawn Not applicable Interventional

Preoperative (Pre-amputation) Cryoanalgesia to Improve Post-amputation Phantom Limb Pain

NCT06284109
View directory record Official record
Conditions
Postoperative Pain
Interventions
Cryoanalgesia, Sham Cryoanalgesia
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Nov 15, 2026, 5:50 AM EST
Not yet recruiting Not applicable Interventional

Adjustable Prosthetic Sockets for Individuals With Lower Limb Amputation

NCT07397169
View directory record Official record
Conditions
Lower Extremity Amputation
Interventions
Adjustable prosthetic socket
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Nov 15, 2026, 5:50 AM EST
Not listed No phase listed Observational

Evaluation of High-Performance, Customized, Rapidly-Manufacturable Prosthetic Feet That Provide Improved Mobility

NCT05265403
View directory record Official record
Conditions
Amputation of Lower Limb Below Knee
Interventions
Commercially-available energy storage and return prosthetic foot, MIT-Lower Leg Trajectory Error (LLTE) customized prosthetic feet
Drug · Device
Lead sponsor
Massachusetts Institute of Technology
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Nov 15, 2026, 5:50 AM EST
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations

NCT03250442
View directory record Official record
Conditions
Surgical Wound, Wound Heal, Amputation
Interventions
PrevenaTM Device, Standard Dry Dressing
Device · Other
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Nov 15, 2026, 5:50 AM EST
Not listed Not applicable Interventional Accepts healthy volunteers

Study to Assess the Efficacy of Direct Observation and Mental Visualization of Foot Movements to Treat Bilateral Lower Limb Phantom Limb Pain

NCT00639431
View directory record Official record
Conditions
Phantom Limb Pain
Interventions
direct observation, mental visualization
Behavioral
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 12, 2014 · Synced Nov 15, 2026, 5:50 AM EST
Completed No phase listed Observational

Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing

NCT02440295
View directory record Official record
Conditions
Wound Healing, Lower Extremity Amputation, Above Knee Amputation, Below Knee Amputation
Interventions
Lower Extremity Amputation, SPY Elite Imaging System, Indocyaine Green
Procedure · Device · Drug
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Nov 15, 2026, 5:50 AM EST
Completed Not applicable Interventional

Spinal Root and Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees

NCT03027947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 12, 2022 · Synced Nov 15, 2026, 5:50 AM EST
Recruiting Not applicable Interventional

Bio Leg: Advancing Mobility (BAM)

NCT07613502
View directory record Official record
Conditions
Amputation of Lower Limb Above Knee, Amputee, Amputation
Interventions
Bio Leg
Device
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 26, 2026 · Synced Nov 15, 2026, 5:50 AM EST