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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Limb Amputees Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Physiologic Range of Step-by-step Variations in Lower Limb Prosthesis Forces During Walking

NCT02234505
View directory record Official record
Conditions
Trans-tibial Limb Loss
Interventions
Prosthetic alignment perturbation
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 3, 2015 · Synced Sep 29, 2026, 2:26 AM EDT
Not yet recruiting Not applicable Interventional

Personalized Prosthetic Foot Prescription and Rehabilitation for Veterans With Lower Limb Loss

NCT06844305
View directory record Official record
Conditions
Amputation of Lower Limb
Interventions
Prosthetic foot, Physical therapy
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Low Cost Socket for Lower Limb Amputees

NCT04725461
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Limb, Amputation, Traumatic
Interventions
Low cost lower limb prosthetic socket
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 95 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 16, 2025 · Synced Sep 29, 2026, 2:26 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluation of Limb Health Associated With a Prosthetic Vacuum Socket System

NCT01839123
View directory record Official record
Conditions
Lower Limb Amputation
Interventions
Prosthetic Suction or Pin Socket, Prosthetic LimbLogic Vacuum Socket
Device
Lead sponsor
Ohio Willow Wood
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Columbus, Ohio • Mount Sterling, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 30, 2013 · Synced Sep 29, 2026, 2:26 AM EDT
Completed No phase listed Observational

Prosthetic Fit Assessment in Transtibial Amputees Secondary to Trauma

NCT02540681
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Not listed
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
10
States / cities
San Francisco, California • Tampa, Florida • Baltimore, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced Sep 29, 2026, 2:26 AM EDT
Active, not recruiting No phase listed Observational

Kinematics of Ewing Amputees

NCT06371209
View directory record Official record
Conditions
Lower Extremity Amputation, Trans-Tibial Amputation, Traumatic Lower Extremity Amputation, Agonist-Antagonist Myoneural Interface
Interventions
Modified Amputation, Standard Amputation
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking

NCT00985842
View directory record Official record
Conditions
Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
Interventions
Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension, Total surface bearing suction socket with a sleeve suspension, Vacuum-assisted socket system (Harmony System, Otto Bock)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 28, 2018 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Wearing a Powered Ankle-Foot Prosthesis on Amputee Walking

NCT00869947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Powered ankle-foot prosthesis, No device
Device · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 60 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 24, 2014 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Phase 1 Interventional

Effect of Socket Wall Height With Vacuum Suspension for Above Knee Amputees

NCT01559909
View directory record Official record
Conditions
Amputation
Interventions
Vacuum assisted socket technology (Harmony System, Otto Bock Healthcare)
Device
Lead sponsor
Stony Brook University
Other
Eligibility
21 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Stony Brook, New York • West Babylon, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2014 · Synced Sep 29, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment

NCT05425810
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury)
Interventions
Apply ENABLE sensing pad, Insert small pads at pressure tolerant locations
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 99 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Phase 1 Interventional

Treadmill Training With Lower Extremity Amputees

NCT01419288
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Treadmill Training
Other
Lead sponsor
Stony Brook University
Other
Eligibility
21 Years to 70 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2013 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

LASER Pilot Project

NCT05966636
View directory record Official record
Conditions
Acquired Absence of Lower Limb, Scar Condition and Fibrosis of the Skin
Interventions
Fractional CO2 Laser Ablative Resurfacing
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Miami, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees

NCT05267639
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions
Power Knee
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Holliston, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 29, 2026, 2:26 AM EDT
Completed No phase listed Observational

Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles Tendon

NCT01382628
View directory record Official record
Conditions
Diabetic Foot Ulcers, Equinus Deformity
Interventions
Not listed
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Socket Cooling Effectiveness Take Home Study

NCT04484805
View directory record Official record
Conditions
Amputation, Amputation; Traumatic, Leg, Lower, Amputation Stump, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Interventions
ICE Condition, Sham Condition
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
2
States / cities
Holliston, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional

Spinal Root and Spinal Cord Stimulation for Restoration of Function in Lower-Limb Amputees

NCT03027947
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity, Phantom Limb Pain
Interventions
Spinal cord stimulator
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Sep 29, 2026, 2:26 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Musculoskeletal Measurements in Transfemoral Amputees

NCT00909922
View directory record Official record
Conditions
Lower Limb Loss
Interventions
Not listed
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2009 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional Results available

EmPOWERing Active Seniors With Energy

NCT02958553
View directory record Official record
Conditions
Amputation
Interventions
emPOWER Ankle, Subject's own passive prosthesis
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
55 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Sep 29, 2026, 2:26 AM EDT
Not listed Phase 2 Interventional

Prosthetic Limbs After Leg Amputation: Alternative Method of Socket Design

NCT00061217
View directory record Official record
Conditions
Amputation
Interventions
Unrectified prosthetic socket, Rectified prosthetic socket
Device
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 29, 2026, 2:26 AM EDT
Not listed Not applicable Interventional

NIH Release/Relock Socket

NCT04305782
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury)
Interventions
Release/Relock Socket - In Lab, Release/Relock Socket - Out of Lab, Release/Relock Socket & Control
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 28, 2024 · Synced Sep 29, 2026, 2:26 AM EDT
Not listed Phase 1 Interventional

Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation

NCT00388752
View directory record Official record
Conditions
Phantom Limb, Residual Limb Pain, Traumatic Amputation, Amputation
Interventions
Acupuncture
Procedure
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 5, 2007 · Synced Sep 29, 2026, 2:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Massage on Pain Levels, Range of Motion, and Muscle Strength in Unilateral Lower Limb Amputees

NCT03389334
View directory record Official record
Conditions
Amputation
Interventions
massage
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2018 · Synced Sep 29, 2026, 2:26 AM EDT
Terminated Not applicable Interventional Results available

Moisture Management Liner At-Home Evaluation

NCT05124873
View directory record Official record
Conditions
Amputation Stump, Amputation, Amputees, Lower Limb Deformity, Prosthesis User, Prosthesis
Interventions
Moisture Management Liner
Device
Lead sponsor
Liberating Technologies, Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Holliston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2025 · Synced Sep 29, 2026, 2:26 AM EDT
Recruiting Not applicable Interventional

Feasibility of Neural Feedback for Lower Limb Amputees

NCT03409133
View directory record Official record
Conditions
Amputation
Interventions
Stimulating nerve electrodes and intramuscular recording electrodes
Device
Lead sponsor
Louis Stokes VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 29, 2026, 2:26 AM EDT