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Showing 1–24 of 158 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Limb Functions Clear all
Completed No phase listed Observational Accepts healthy volunteers

Evaluating Muscle Function After Ankle Surgery

NCT00060970
View directory record Official record
Conditions
Muscle Atrophy, Muscle Weakness, Fractures
Interventions
Physical Therapy
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 2000
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 22, 2026, 2:04 PM EDT
Not listed Not applicable Interventional

Effect of Lower Leg Heating and Transcutaneous Electrical Nerve Stimulation on Exercise Capacity in Patients With PAD

NCT03462472
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Lower leg heating, Lower leg transcutaneous electrical nerve stimulation (TENS)
Behavioral
Lead sponsor
Salisbury University
Other
Eligibility
40 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Salisbury, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 11, 2018 · Synced Jul 22, 2026, 2:04 PM EDT
Active, not recruiting Not applicable Interventional

HABIT-ILE + FST in Children With SMA

NCT07223320
View directory record Official record
Conditions
SMA - Spinal Muscular Atrophy
Interventions
Combined Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) + functional strength training (FST)
Other
Lead sponsor
Teachers College, Columbia University
Other
Eligibility
5 Years to 17 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional

Effect of a Boxing Program on People With Parkinson Disease

NCT04781842
View directory record Official record
Conditions
Parkinson Disease
Interventions
Boxing exercise program
Other
Lead sponsor
Husson University
Other
Eligibility
Not listed
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Bangor, Maine
Source: ClinicalTrials.gov public record
Updated Mar 26, 2023 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Phase 4 Interventional

CLARIX™ 100 & CLARIX CORD 1K for Discectomy Patients

NCT03113786
View directory record Official record
Conditions
Protruded Disk
Interventions
CLARIX™100, CLARIX CORD 1K
Other
Lead sponsor
Amniox Medical, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Bensalem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Training Improves Balance Control

NCT01547988
View directory record Official record
Conditions
Accidental Falls
Interventions
Balance Training Intervention
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
65 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2003
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional

Enhancing Motor Function in Individuals with Lower Limb Amputation

NCT06638723
View directory record Official record
Conditions
Amputation
Interventions
Balance and fall recovery training
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jul 22, 2026, 2:04 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instability

NCT03428620
View directory record Official record
Conditions
Ankle Sprains
Interventions
High Velocity Low Amplitude mobilization, Exercise protocol
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Fayetteville, North Carolina • Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2018 · Synced Jul 22, 2026, 2:04 PM EDT
Terminated No phase listed Observational

Retrospective Study of the Linear™ Hip

NCT00764959
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Femoral Fracture, Correction of a Functional Deformity, Avascular Necrosis
Interventions
Encore Linear™ Hip System
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Vero Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 8, 2011 · Synced Jul 22, 2026, 2:04 PM EDT
Enrolling by invitation Not applicable Interventional

Arm and Leg Cycling for Accelerated SCI Recovery

NCT06873776
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
A&L cycling, Body weight supported treadmill training (BWSTT)
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Jul 22, 2026, 2:04 PM EDT
Completed No phase listed Observational

Pilon Fracture Reduction and Functional Outcome

NCT01316289
View directory record Official record
Conditions
Pilon Fracture of Tibia
Interventions
Not listed
Lead sponsor
AO Clinical Investigation and Publishing Documentation
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
Indianapolis, Indiana • Saint Paul, Minnesota • Jackson, Mississippi + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional

The Effect of Cupping on Spasticity and Function of the Lower Extremity During Rehabilitation After Stroke

NCT06653855
View directory record Official record
Conditions
Stroke Gait Rehabilitation
Interventions
Dry Static Cupping, Placebo cupping, Standard physical therapy treatment
Other
Lead sponsor
Scott Getsoian
Industry
Eligibility
30 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Joliet, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ultrasound for Quantifying Muscle Activation Elicited by Spinal Cord Stimulation and Functional Electrical Stimulation

NCT07206797
View directory record Official record
Conditions
Neuromodulatory Effects of TSCS and FES in Lower Limbs
Interventions
Functional Electrical Stimulation, Transcutaneous (Non-Invasive) Spinal Cord Stimulation, Ultrasound
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project Hypnos: The Impact of a Brief Hypnosis Intervention on Single-limb Dynamic Balance in People With Chronic Ankle Instability

NCT06390072
View directory record Official record
Conditions
Ankle Sprains, Motor Coordination or Function; Developmental Disorder
Interventions
Self-Hypnosis, Ankle Education
Behavioral
Lead sponsor
Ohio University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Athens, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 28, 2024 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional

Feasibility and Effectiveness of Goal Driven Extended Reality for Lower Limb Rehabilitation

NCT07043101
View directory record Official record
Conditions
Gait Rehabilitation
Interventions
Extended Reality based Gait Rehabilitation
Other
Lead sponsor
University at Albany
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Schenectady, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2025 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional

Effects of Exoskeleton-Assisted Gait Training on Functional Rehabilitation Outcomes in Patients With Stroke

NCT03980457
View directory record Official record
Conditions
Stroke, Weakness of Extremities as Sequela of Stroke
Interventions
Indego Exoskeleton, Standard Rehabilitation
Device · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional

Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

NCT05929508
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Ischemic Preconditioning
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional

Regenerative Peripheral Nerve Interface for Control of Lower Limb Prostheses

NCT06275282
View directory record Official record
Conditions
Amputation, Prostheses and Implants
Interventions
Intramuscular electrodes
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 75 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Training of Eccentric Lower Extremity Function After SCI

NCT02498548
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Trained SCI Knee or Trained SCI Hip
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 90 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 18, 2021 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients

NCT06541015
View directory record Official record
Conditions
Hemiplegia and/or Hemiparesis Following Stroke, Anterior Circulation Stroke of Uncertain Pathology
Interventions
InTENSity 10 TENS Stimulator
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 22, 2026, 2:04 PM EDT
Completed No phase listed Observational

Leg Function and ADL After ALT Reconstruction for Head and Neck Cancer

NCT02332161
View directory record Official record
Conditions
Free Tissue Flaps, Head and Neck Neoplasms
Interventions
surveys, evaluative tests for leg function
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Jul 22, 2026, 2:04 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Comparative Study: Non-Surgical Spinal Decompression and Spinal Manipulative Therapy- Utilizing a Quantifiable Musculoskeletal Functional Assessment Risk Analysis Tool (MSDR®) in Patients With Chronic Low Back Pain

NCT00732394
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
MSDR
Other
Lead sponsor
MedAppraise, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Clearwater, Florida
Source: ClinicalTrials.gov public record
Updated Aug 11, 2008 · Synced Jul 22, 2026, 2:04 PM EDT
Completed Not applicable Interventional Results available

Functional Outcomes in Dysvascular Transfemoral Amputees

NCT01537211
View directory record Official record
Conditions
Transfemoral Amputation, Unilateral Traumatic Amputation of Leg at or Above Knee
Interventions
C leg compared to subject's mechanical leg (Otto Bock)
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Jul 22, 2026, 2:04 PM EDT
Recruiting No phase listed Observational

Pelvic and Acetabular Fracture: A Prospective Observational Study

NCT04615104
View directory record Official record
Conditions
Pelvic Fracture, Acetabular Fracture, Pubic Rami Fracture
Interventions
Operative, Nonoperative
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Jul 22, 2026, 2:04 PM EDT