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Showing 1–24 of 25 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower-limb Orthoses Clear all
Withdrawn No phase listed Observational Accepts healthy volunteers

SCANLOAD: The Effect of Limb Loading on Lower Limb Geometry

NCT04600102
View directory record Official record
Conditions
Foot Injuries and Disorders
Interventions
Structure Sensor
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 10, 2022 · Synced Jul 23, 2026, 8:59 PM EDT
Recruiting Not applicable Interventional

IM ABLE 2: Injuries Managed With Advanced Bracing for Lower Extremities

NCT07721792
View directory record Official record
Conditions
Lower Limb Injury, Ankle Foot Orthosis (AFO), Lower Limb Trauma
Interventions
Advanced Ankle Foot Orthosis (AFO), Conventional Ankle Foot Orthosis (AFO)
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
3
States / cities
Tampa, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Jul 23, 2026, 8:59 PM EDT
Terminated Not applicable Interventional Results available

Effect of Lower Extremity Ankle Foot Orthoses in Parkinson's Disease

NCT01798927
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Ankle foot orthosis
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
50 Years to 75 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 2, 2015 · Synced Jul 23, 2026, 8:59 PM EDT
Recruiting Not applicable Interventional

Improving Walking After a Lower Limb Injury Using a Custom Motorized Orthosis

NCT06923293
View directory record Official record
Conditions
Lower Limb Injury
Interventions
Utilization of motorized orthosis
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Jul 23, 2026, 8:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics

NCT05456295
View directory record Official record
Conditions
Healthy, Lower Limb Injury, Post-Traumatic Osteoarthritis
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 8:59 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Ankle-foot Orthoses Trim Line Modifications on Ankle and Knee Motion and Force.

NCT01865682
View directory record Official record
Conditions
Lower Extremity Biomechanics
Interventions
Not listed
Lead sponsor
Southern California Institute for Research and Education
Other
Eligibility
18 Years to 40 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Jul 23, 2026, 8:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating Mobility Interventions in the Real World

NCT04275973
View directory record Official record
Conditions
Lower Limb Amputation, Drop Foot
Interventions
Lower limb prostheses, Orthoses for Drop-foot
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jul 23, 2026, 8:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress

NCT04562896
View directory record Official record
Conditions
Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions
Custom Carbon Fiber Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jul 23, 2026, 8:59 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses

NCT05240014
View directory record Official record
Conditions
Lower-limb Orthoses, Frailty/Sarcopenia, Chronic Overuse Musculoskeletal Injuries
Interventions
Modular powered orthosis
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 85 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 23, 2026, 8:59 PM EDT
Completed No phase listed Observational

Improved Training Program for Fall Prevention of War Fighters

NCT03446131
View directory record Official record
Conditions
Limb Injury
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
4
States / cities
San Diego, California • Bethesda, Maryland • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Jul 23, 2026, 8:59 PM EDT
Recruiting No phase listed Observational

C-Brace Prospective Registry

NCT04640584
View directory record Official record
Conditions
Pareses, Lower Extremity
Interventions
C-Brace
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
Not listed
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
70
States / cities
Harrison, Arkansas • Rogers, Arkansas • San Diego, California + 63 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Jul 23, 2026, 8:59 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers Results available

SCANREP: Reliability of 3D Lower Limb Scanning

NCT04032041
View directory record Official record
Conditions
Foot Injuries and Disorders
Interventions
Structure Sensor, Caliper
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Jul 23, 2026, 8:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Malleo-Lok Stiffness on Lower Limb Mechanics

NCT04806100
View directory record Official record
Conditions
Adult ALL, Healthy
Interventions
Malleo-Lok
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 14, 2023 · Synced Jul 23, 2026, 8:59 PM EDT
Not listed Not applicable Interventional

The IM ABLE Study: A Study of Warriors & Veterans Following Neuromusculoskeletal Injury of the Lower Limb

NCT03107728
View directory record Official record
Conditions
Limb Salvage, Braces, Lower Extremity
Interventions
Advanced orthotic brace, Conventional orthotic brace
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 19, 2019 · Synced Jul 23, 2026, 8:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Custom Molded Foot Orthoses Effect on Foot Kinematics and Lower Extremity Electromyography During Walking and Running.

NCT02143947
View directory record Official record
Conditions
Lower Extremity Pain of a Mechanical Origin
Interventions
Maximal Arch Subtalar Stabilization, Full Contact Orthosis
Device
Lead sponsor
Quinnipiac University
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Hamden, Connecticut
Source: ClinicalTrials.gov public record
Updated May 17, 2015 · Synced Jul 23, 2026, 8:59 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Orthotic Dose Response Study

NCT02629731
View directory record Official record
Conditions
Ankle Osteoarthritis, Flat Foot or Pes Planus
Interventions
custom orthoses with varying degrees of hindfoot posting
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Jul 23, 2026, 8:59 PM EDT
Recruiting Not applicable Interventional

The Effects of Heel Distraction Height on Foot Loading With Carbon Fiber Custom Dynamic Orthoses

NCT06127316
View directory record Official record
Conditions
Traumatic Lower Limb Injury
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 8:59 PM EDT
Active, not recruiting Not applicable Interventional

Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis

NCT02089880
View directory record Official record
Conditions
Spinal Cord Injuries, Poliomyelitis, Post-polio Syndrome, Arthritis, Lower Motor Neurone Lesion
Interventions
C-brace, Stance control orthosis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Jul 23, 2026, 8:59 PM EDT
Completed Not applicable Interventional Results available

Clinical Trial Comparing C-Brace to Knee Ankle Foot Orthosis (KAFO)/Stance Control Orthosis (SCO)

NCT03906656
View directory record Official record
Conditions
Pareses, Lower Extremity
Interventions
C-Brace, KAFO/SCO
Device
Lead sponsor
Otto Bock Healthcare Products GmbH
Industry
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
4
States / cities
Sarasota, Florida • Chicago, Illinois • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 23, 2026, 8:59 PM EDT
Completed Not applicable Interventional Results available

Ankle Foot Orthosis Comparative Effect

NCT03901053
View directory record Official record
Conditions
Foot Injuries and Disorders
Interventions
Reaktiv AFO, PhatBrace AFO
Device
Lead sponsor
Jason Wilken
Other
Eligibility
18 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
3
States / cities
Iowa City, Iowa • Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jul 23, 2026, 8:59 PM EDT
Terminated Not applicable Interventional

Customized Orthosis for Children With Clubfoot

NCT03853811
View directory record Official record
Conditions
Congenital Talipes Equinovarus
Interventions
Ankle Foot Orthosis (AFO)
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Up to 12 Months
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 10, 2022 · Synced Jul 23, 2026, 8:59 PM EDT
Recruiting Not applicable Interventional

Impact of Foot Orthoses on Gait in Individuals With Ataxia

NCT07720700
View directory record Official record
Conditions
Ataxia
Interventions
Home wearing schedule
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Jul 23, 2026, 8:59 PM EDT
Withdrawn Not applicable Interventional

Custom Dynamic Orthoses to Reduce Articular Contact Stress

NCT05209347
View directory record Official record
Conditions
Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Jul 23, 2026, 8:59 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal

NCT07673328
View directory record Official record
Conditions
Lower-limb Orthoses, Osteoarthritic Knee Pain, Osteoarthritis (OA) of the Knee
Interventions
Modular powered orthosis
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 85 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 23, 2026, 8:59 PM EDT