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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lumbar Back Pain Clear all
Active, not recruiting Phase 2 Interventional

Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

NCT05463367
View directory record Official record
Conditions
Opioid Use, Opioid Dependence, Opioid-use Disorder, Narcotic Use, Back Pain, Back Injuries, Chronic Pain, Chronic Low-back Pain, Pain, Chronic, Pain;Back Low;Chronic, Pain, Back
Interventions
Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Not applicable Interventional Results available

Cramer Sports Motion Tape and Low Back Pain EMG

NCT02122445
View directory record Official record
Conditions
Low Back Pain
Interventions
Cramer Sports Motion Tape
Device
Lead sponsor
Sport and Spine Rehab Clinical Research Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 8, 2016 · Synced Sep 25, 2026, 7:17 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Large Array EMG Discriminability in Discogenic Low Back Pain

NCT00220948
View directory record Official record
Conditions
Discogenic Pain
Interventions
CERSR Myoelectric monitoring during standardized tasks
Procedure
Lead sponsor
Texas Back Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2005 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Not applicable Interventional

Low Back Pain Patient Education Evaluation

NCT00000408
View directory record Official record
Conditions
Low Back Pain
Interventions
Patient education evaluation
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
580 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2002
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 2, 2013 · Synced Sep 25, 2026, 7:17 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Analysis of Crepitus in Human Subjects

NCT05425017
View directory record Official record
Conditions
Low Back Pain, Healthy
Interventions
Range of motion with spinal adjustment
Other
Lead sponsor
National University of Health Sciences
Other
Eligibility
30 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 4, 2024 · Synced Sep 25, 2026, 7:17 PM EDT
Terminated Not applicable Interventional Results available

Dexamethasone Versus Depo Medrol in Lumbar Epidurals

NCT01397552
View directory record Official record
Conditions
Lumbar Spine Disc Herniation, Lumbar Radiculitis, Lumbar Back Pain
Interventions
Dexamethasone, methylprednisolone acetate
Drug
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
21 Years to 89 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
East Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Phase 2 Interventional

Efficacy and Safety of EN3324 (Axomadol) in Subjects With Chronic Low Back Pain

NCT01043263
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
EN3324 (axomadol), Placebo
Drug
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
59
States / cities
Phoenix, Arizona • Tucson, Arizona • Tuscon, Arizona + 43 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2015 · Synced Sep 25, 2026, 7:17 PM EDT
Not listed Phase 4 Interventional

Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain

NCT00444990
View directory record Official record
Conditions
Low Back Pain
Interventions
Magnetic Flex Pad
Device
Lead sponsor
Weintraub, Michael I., MD, FACP, FAAN
Individual
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
1
States / cities
Briarcliff Manor, New York
Source: ClinicalTrials.gov public record
Updated Sep 20, 2007 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Phase 2Phase 3 Interventional Results available

A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy

NCT00733096
View directory record Official record
Conditions
Lumbosacral Radiculopathy
Interventions
etanercept, methylprednisolone, normal saline
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 70 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 7, 2012 · Synced Sep 25, 2026, 7:17 PM EDT
Terminated Phase 2 Interventional

Percutaneous Dynamic Stabilization (PDS) System Versus Fusion for Treating Degenerative Disc Disease

NCT00878579
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
PDS System, Fusion
Device
Lead sponsor
Interventional Spine, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Cincinnati, Ohio • Willow Grove, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 20, 2013 · Synced Sep 25, 2026, 7:17 PM EDT
Completed No phase listed Observational

Post Epidural Steroid Injection Follow-up

NCT04207606
View directory record Official record
Conditions
Lumbago, Lumbar Spinal Stenosis, Lumbar Disc Herniation
Interventions
Post Epidural Steroid Injection Follow-up
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Timeline
2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Sep 25, 2026, 7:17 PM EDT
Recruiting Not applicable Interventional

DBS of the SCC for the Treatment of Medically Refractory CLBP

NCT04085406
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Deep Brain Stimulation of the Subgenus Cingulate Cortex
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
40 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Los Angeles, California • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Not applicable Interventional

Impact of DuoTherm Compared to TENS on Pain and Disability With Acute and Chronic Low Back Pain

NCT04494698
View directory record Official record
Conditions
Acute Low-back Pain, Chronic Low-back Pain, Pain, Intractable
Interventions
Duotherm VibraCool Back Device, TENS 8-channel unit
Device
Lead sponsor
MMJ Labs LLC
Industry
Eligibility
18 Years to 90 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Landover, Maryland • Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 25, 2026, 7:17 PM EDT
Not listed Not applicable Interventional

Cost Effectiveness and Clinical Utility of Cell Saver Use for Two to Three Level Lumbar Fusions

NCT01453309
View directory record Official record
Conditions
Low Back Pain Unresponsive to Non-surgical Care
Interventions
Cell Saver, No Cell Saver
Procedure
Lead sponsor
Norton Leatherman Spine Center
Other
Eligibility
18 Years to 80 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 16, 2011 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Not applicable Interventional

Role of Steroids and 10% Hypertonic Sodium Chloride in Adhesiolysis in Post Lumbar Surgery Syndrome Patients

NCT01053572
View directory record Official record
Conditions
Low Back Pain
Interventions
Adhesiolysis
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 25, 2026, 7:17 PM EDT
Not listed Not applicable Interventional

Verbalization in Patients With Non-specific Low Back Pain and Central Sensitization

NCT01705600
View directory record Official record
Conditions
Central Sensitization, Low Back Pain, Pain Catastrophizing
Interventions
Pain Verbalization Repression Rules
Behavioral
Lead sponsor
Keystone Rehabilitation Systems
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 11, 2012 · Synced Sep 25, 2026, 7:17 PM EDT
Recruiting Not applicable Interventional

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

NCT04142177
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Pain EASE, Tailored exercise, Continued Care and Active Monitoring, Cognitive Behavioral Therapy (CBT), Spinal Manipulation Therapy (SMT), Yoga
Other · Procedure · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
2,529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
19
States / cities
Phoenix, Arizona • Loma Linda, California • Long Beach, California + 16 more
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Phase 4 Interventional Results available

Effectiveness of Ultrasound Guided Platelet Rich Plasma Injections in the Sacroiliac Joint

NCT03122119
View directory record Official record
Conditions
Chronic Low Back Pain, Sacroiliitis, Sacroiliac; Backache, Platelet Rich Plasma, Platelet, Injection Site, Ultrasound Therapy; Complications, Treatment
Interventions
Platelet Rich Plasma Joint Injection
Drug
Lead sponsor
Star Spine and Sport
Other
Eligibility
18 Years to 80 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Golden, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Sep 25, 2026, 7:17 PM EDT
Not listed Phase 2Phase 3 Interventional

Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs

NCT04559295
View directory record Official record
Conditions
Low Back Pain, Disc Disease, Disc Degeneration, Arthropathy Vertebrae, Sacral Disorder, Radiculopathy, Spinal Stenosis
Interventions
Bone Marrow Concentrate
Biological
Lead sponsor
Stem Cures
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Not applicable Interventional

Chronic Low Back Pain Graded - Exposure Psychoeducation Intervention

NCT03909048
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Interactive - Psychoeducation, Non-interactive Psychoeducation
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 30, 2019 · Synced Sep 25, 2026, 7:17 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Pilot Study to Assess the Efficacy of Botulinum Toxin A Treatments on Pain and Disability in Sub-Acute Low Back Pain

NCT00384371
View directory record Official record
Conditions
Low Back Pain
Interventions
Botulinum Toxin A, Placebo
Drug
Lead sponsor
United States Department of Defense
Federal
Eligibility
18 Years to 60 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Mar 4, 2009 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)

NCT04479787
View directory record Official record
Conditions
Chronic Low-Back Pain, Refractory Pain, Neuropathic Pain
Interventions
Spinal Cord Stimulation, Conventional Medical Management
Device · Other
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
30
States / cities
Phoenix, Arizona • Tucson, Arizona • Camarillo, California + 27 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Not applicable Interventional

Interventional Study of Effects on Spine Height With Two Unloading Positions

NCT01048749
View directory record Official record
Conditions
Low Back Pain
Interventions
aquatic vertical suspension., land-based supine flexion
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
40 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Cleburne, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2010 · Synced Sep 25, 2026, 7:17 PM EDT
Completed Not applicable Interventional Results available

Safety and Efficacy of the TransDiscal System Versus Medical Management in Treating Chronic Discogenic Low Back Pain

NCT01263054
View directory record Official record
Conditions
Back Pain
Interventions
TransDiscal System, Medical Management
Device · Other
Lead sponsor
Halyard Health
Industry
Eligibility
21 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
9
States / cities
Washington D.C., District of Columbia • Orlando, Florida • Bloomington, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Sep 25, 2026, 7:17 PM EDT