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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lumbar Facet Syndrome Clear all
Completed Early Phase 1 Interventional

Platelet-Rich Plasma (PRP) for Treatment of Symptomatic Lumbar Facet Syndrome of the Spine

NCT04522674
View directory record Official record
Conditions
Platelet-Rich Plasma
Interventions
Autologous platelet rich plasma
Biological
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 95 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Jul 22, 2026, 9:04 AM EDT
Completed Phase 3 Interventional

A Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves for theTreatment of Lumbar Facet Syndrome

NCT02478437
View directory record Official record
Conditions
Low Back Pain
Interventions
Conventional radiofrequency ablation (RFA), Cooled Radiofrequency Ablation (CRFA)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 79 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 5, 2018 · Synced Jul 22, 2026, 9:04 AM EDT
Not listed Phase 3 Interventional

Synvisc Injections for Lumbar Facet Joint Pain

NCT00325845
View directory record Official record
Conditions
Joint Pain
Interventions
Synvisc viscosupplementation
Procedure
Lead sponsor
Sheltering Arms Physical Rehabilitation Hospitals
Other
Eligibility
30 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 12, 2006 · Synced Jul 22, 2026, 9:04 AM EDT
Recruiting Not applicable Interventional

Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks

NCT05961800
View directory record Official record
Conditions
Pain, Chronic, Facet Joint Pain, Pain, Procedural, Analgesia
Interventions
Cutaneous Probe, Quantitative Sensory Testing, Computer Tasks
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 22, 2026, 9:04 AM EDT
Completed Not applicable Interventional Results available

Cryoneurolysis for Facet Mediated Chronic Low Back Pain

NCT06016127
View directory record Official record
Conditions
Low Back Pain, Facet Joint Pain
Interventions
iovera system, Radiofrequency ablation
Device
Lead sponsor
Medical Pain Management Services, PLLC
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Saratoga Springs, New York
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Jul 22, 2026, 9:04 AM EDT
Completed Not applicable Interventional

Medial Branch Blocks vs. Intra-articular Injections: Randomized, Controlled Study

NCT02002429
View directory record Official record
Conditions
Lumbar Facet Joint Pain, Low Back Pain
Interventions
Intra-articular injection, Medial branch block, Saline injection
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Baltimore, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2018 · Synced Jul 22, 2026, 9:04 AM EDT
Completed Not applicable Interventional Results available

FDG PET/MRI Evaluation of Facet Joint Pain

NCT02921490
View directory record Official record
Conditions
Low Back Pain
Interventions
FDG PET/MR examination.
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Jul 22, 2026, 9:04 AM EDT
Completed Not applicable Interventional

Double Arm Pivotal Study to Evaluate the Neurolyser XR for the Treatment of Chronic Low Back Pain

NCT05154448
View directory record Official record
Conditions
Facet Syndrome of Lumbar Spine
Interventions
Non-Invasive Thermal Ablation of the Medial Branch Nerves (Neurolyser XR), Sham procedure
Device · Other
Lead sponsor
FUSMobile Inc.
Industry
Eligibility
50 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
10
States / cities
Stamford, Connecticut • Jacksonville, Florida • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Jul 22, 2026, 9:04 AM EDT
Recruiting Not applicable Interventional

A Prospective Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain

NCT07214844
View directory record Official record
Conditions
Low Back Pain, Chronic
Interventions
Iovera Medial Branch Cryoneurolysis, Radiofrequency ablation (RFA)
Device · Procedure
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 22, 2026, 9:04 AM EDT
Completed Not applicable Interventional Results available

A Prospective Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves Versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome

NCT03614793
View directory record Official record
Conditions
Lumbar Facet Syndrome
Interventions
Cooled Radiofrequency Ablation of Medial Branch Nerves versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome
Procedure
Lead sponsor
University of Utah
Other
Eligibility
21 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Jul 22, 2026, 9:04 AM EDT
Recruiting Phase 1 Interventional

Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Lumbar Pain

NCT06361485
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Injections with 10cc's of Wharton's Jelly Allograft
Biological
Lead sponsor
R3 Stem Cell
Industry
Eligibility
20 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
4
States / cities
Scottsdale, Arizona • Beverly Hills, California • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2024 · Synced Jul 22, 2026, 9:04 AM EDT
Withdrawn Not applicable Interventional

MR Guided High Intensity Focused Ultrasound for Lumbar Back Pain

NCT02291978
View directory record Official record
Conditions
Lumbar Facet Joint Pain
Interventions
ExAblate 2100
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Jul 22, 2026, 9:04 AM EDT
Completed Not applicable Interventional

Platelet Rich Plasma (PRP) for Facet Mediated Lumbar Low Back Pain

NCT04822753
View directory record Official record
Conditions
Facet Joint Pain; Low Back Pain
Interventions
Platelet Rich Plasma injection to the lumbar facet joint
Procedure
Lead sponsor
Womack Army Medical Center
Federal
Eligibility
18 Years to 75 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Fort Liberty, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Jul 22, 2026, 9:04 AM EDT
Terminated Not applicable Interventional

A Multi-Site Study of the Zyga GlyDer Facet Restoration Device In Subjects With LUmbar FacET Pain Syndrome - DUET

NCT02179476
View directory record Official record
Conditions
Facet Joint Pain
Interventions
Glyder
Device
Lead sponsor
Zyga Technology, Inc.
Industry
Eligibility
22 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
4
States / cities
Santa Monica, California • Tampa, Florida • Edmond, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Jul 22, 2026, 9:04 AM EDT
Not listed No phase listed Observational

Technical Description of Cooled Radiofrequency Ablation of Lumbar Medial Branches for the Treatment of Lumbar Facet Pain

NCT01590004
View directory record Official record
Conditions
Lumbar Facet Joint Pain
Interventions
Not listed
Lead sponsor
Mehul Desai
Industry
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated May 18, 2015 · Synced Jul 22, 2026, 9:04 AM EDT
Not listed Not applicable Interventional

Cooled RFA vs Conventional RFA to Manage Chronic Facetogenic Low Back Pain

NCT04803149
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Cooled Radiofrequency, Conventional Radiofrequency
Device
Lead sponsor
Avanos Medical
Other
Eligibility
21 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
10
States / cities
Washington D.C., District of Columbia • Bloomington, Illinois • New Orleans, Louisiana + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Jul 22, 2026, 9:04 AM EDT