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Showing 1–24 of 62 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lumbar Pain Syndrome Clear all
Terminated Phase 4 Interventional Results available

Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy

NCT00619983
View directory record Official record
Conditions
Diabetic Neuropathic Pain, Chronic Low Back Pain
Interventions
donepezil, duloxetine, donepezil 2.5 mg and duloxetine 30mg, placebo, gabapentin
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 80 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Music-based Treatments and Pain: Underlying Mechanisms and the Beneficial Effects of Music-Based Treatments

NCT05578781
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Music Therapy, Music Medicine, Control group
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional Results available

Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)

NCT02697435
View directory record Official record
Conditions
Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia, Depression, Maladaptive Coping, Lumbar Spinal Stenosis, Insomnia, Sacroiliac Joint Pain, Lateral Hip and Thigh Pain, Anxiety, Dementia, Recent Leg Length Discrepancy
Interventions
Patient-Centered Care, Imaging-Directed Care
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 89 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 18, 2019 · Synced Jun 26, 2026, 3:50 AM EDT
Recruiting Phase 1 Interventional

Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Lumbar Pain

NCT06361485
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Injections with 10cc's of Wharton's Jelly Allograft
Biological
Lead sponsor
R3 Stem Cell
Industry
Eligibility
20 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
4
States / cities
Scottsdale, Arizona • Beverly Hills, California • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2024 · Synced Jun 26, 2026, 3:50 AM EDT
Recruiting Not applicable Interventional

Imaging Metabolic and Perfusion Changes in Acupuncture Therapy for Myofascial Pain Syndrome

NCT07494162
View directory record Official record
Conditions
Myofascial Pain Syndrome (MPS), Chronic Low-back Pain (cLBP)
Interventions
Acupuncture, Sham Acupuncture, Total-Body PET/CT Imaging
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jun 26, 2026, 3:50 AM EDT
Recruiting Phase 2 Interventional

Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

NCT06419439
View directory record Official record
Conditions
Chronic Low Back Pain, Depression
Interventions
Ketamine hydrochloride, Minimally Enhanced Usual Care, Brief narrative intervention
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional

Biopsychosocial Factors and Muscle Morphology After a Resistance Exercise

NCT07203430
View directory record Official record
Conditions
Low Back Pain, Chronic
Interventions
45-Degree Roman Chair Exercise
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 50 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jun 26, 2026, 3:50 AM EDT
Terminated Not applicable Interventional

A Multi-Site Study of the Zyga GlyDer Facet Restoration Device In Subjects With LUmbar FacET Pain Syndrome - DUET

NCT02179476
View directory record Official record
Conditions
Facet Joint Pain
Interventions
Glyder
Device
Lead sponsor
Zyga Technology, Inc.
Industry
Eligibility
22 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
4
States / cities
Santa Monica, California • Tampa, Florida • Edmond, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Jun 26, 2026, 3:50 AM EDT
Not listed Not applicable Interventional

SynerFuse Spinal Fusion and Neuromodulation Proof of Concept Study

NCT04054401
View directory record Official record
Conditions
Spinal Fusion, Radiculopathy Lumbar, Chronic Pain
Interventions
DRG Neurostimulation with Spinal Fusion
Device
Lead sponsor
SynerFuse, Inc
Other
Eligibility
21 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Mishawaka, Indiana • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 23, 2023 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional

A Pilot Study Examining the Efficacy of Biomodulator Treatment for Chronic Low Back Pain

NCT02707094
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Biomodulator, Usual Care (Medication + Exercise)
Device · Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 62 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2018 · Synced Jun 26, 2026, 3:50 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Multiple Component Mobile-aid Pain Reduction Intervention to Decrease Myofascial Pain

NCT05860205
View directory record Official record
Conditions
Myofascial Pain Syndrome
Interventions
Multiple Component Mobile-Aid Pain Reduction Intervention, Osteopathic Manipulation Treatment, Sham Osteopathic Manipulation
Behavioral · Other
Lead sponsor
Kailea Manning
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated May 15, 2023 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional

Veterans Response to Dosage in Chiropractic Therapy

NCT04087291
View directory record Official record
Conditions
Low Back Pain, Patient Acceptance of Health Care, Veterans Health
Interventions
Chiropractic Care
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years and older
Enrollment
766 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Los Angeles, California • West Haven, Connecticut • Iowa City, Iowa + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Phase 2Phase 3 Interventional

Dose of Spinal Manipulation for Chronic Low Back Pain

NCT00376350
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal Manipulation, Light Massage, Pulsed Ultrasound
Procedure
Lead sponsor
University of Western States
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 23, 2015 · Synced Jun 26, 2026, 3:50 AM EDT
Not listed Phase 4 Interventional

Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery

NCT06066879
View directory record Official record
Conditions
Revision Spine Surgery, Fusion of Spine, Cervical Fusion, Lumbar Fusion
Interventions
Ketamine Hydrochloride
Drug
Lead sponsor
AXIS Spine Center- a division of Northwest Specialty Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Coeur d'Alene, Idaho
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Early Phase 1 Interventional

Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain

NCT00370799
View directory record Official record
Conditions
Low Back Pain
Interventions
Caudal epidural injection, Caudal Epidural Injection with generic Celestone, Caudal Epidural Injection with Celestone, Caudal Epidural Injection with DepoMedrol
Drug
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 15, 2013 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aging Back Clinics

NCT03564600
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Aging Back Clinics management
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 89 Years
Enrollment
299 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
3
States / cities
West Los Angeles, California • Pittsburgh, Pennsylvania • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 19, 2025 · Synced Jun 26, 2026, 3:50 AM EDT
Active, not recruiting No phase listed Observational

Precise and Objective Identification of Bertolotti Syndrome Using Novel Kinematic Biomarkers

NCT06225583
View directory record Official record
Conditions
Bertolotti's Syndrome, Lower Back Pain
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jun 26, 2026, 3:50 AM EDT
Terminated Not applicable Interventional

SENSE (Subcutaneous and Epidural Neuromodulation System Evaluation) Study

NCT01990287
View directory record Official record
Conditions
Failed Back Surgery Syndrome, Post-Laminectomy Syndrome, Low Back Pain
Interventions
SCS and PNfS, SCS Alone
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
22 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
28
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 24 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Veteran Ear Acupuncture Pilot Project

NCT04208659
View directory record Official record
Conditions
Chronic Pain Syndrome, Pain, Fibromyalgia, Low Back Pain, Neuropathic Pain, Neuropathy, Painful, Musculoskeletal Pain, Chronic Pain
Interventions
Self-administration of auricular acupuncture without prosthesis, Self-administration of auricular acupuncture with prosthesis
Procedure
Lead sponsor
Chillicothe VA Medical Center
Federal
Eligibility
18 Years to 120 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chillicothe, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 31, 2021 · Synced Jun 26, 2026, 3:50 AM EDT
Not yet recruiting Phase 3 Interventional

The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients

NCT05279937
View directory record Official record
Conditions
Ehlers-Danlos Syndrome, Low Back Pain, Sacroiliac Instability
Interventions
Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution
Drug
Lead sponsor
Tulane University
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional

Role of Steroids and 10% Hypertonic Sodium Chloride in Adhesiolysis in Post Lumbar Surgery Syndrome Patients

NCT01053572
View directory record Official record
Conditions
Low Back Pain
Interventions
Adhesiolysis
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Jun 26, 2026, 3:50 AM EDT
Completed Not applicable Interventional

Lumbar Manipulation for Hip and Muscle Strength

NCT03101956
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Interventions
Lumbar Spine Manipulation, Lumbar Spine Manipulation Placebo
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Jun 26, 2026, 3:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Correlation Between Central Sensitization Inventory and Posturographic Data

NCT03058003
View directory record Official record
Conditions
Central Nervous System Sensitization
Interventions
Posturography Evaluation, Central Sensitization Inventory
Diagnostic Test · Other
Lead sponsor
Caps Research Network
Other
Eligibility
18 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Jun 26, 2026, 3:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome

NCT03444168
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
22 Years to 70 Years
Enrollment
158 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Jun 26, 2026, 3:50 AM EDT