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ClinicalTrials.gov public records Last synced Oct 22, 2026, 2:34 PM EDT

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Showing 1–24 of 55 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lumbar Puncture Clear all
Not listed Not applicable Interventional

Pediatric Lumbar Puncture Success Using the COMPASS

NCT01285531
View directory record Official record
Conditions
Lumbar Puncture
Interventions
Compass Lumbar Puncture Enhanced
Device
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
Up to 18 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 17, 2011 · Synced Oct 22, 2026, 2:34 PM EDT
Enrolling by invitation Not applicable Interventional

Ultrasound-assisted vs Palpation-guided Lumbar Punctures

NCT07824284
View directory record Official record
Conditions
Lumbar Puncture
Interventions
Ultrasound-Assisted Lumbar Puncture, Standard Palpation-Guided Lumbar Puncture
Procedure · Other
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Camden, New Jersey • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Dural Puncture Epidural Versus Traditional Lumbar Epidural on Onset of Labor Analgesia

NCT02412969
View directory record Official record
Conditions
Labor Pain, Labor Analgesia
Interventions
Lumbar Epidural, Dural Puncture Epidural
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 17, 2016 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional

Propofol Versus Propofol-Fentanyl as Sedation For Lumbar Puncture in Children With Acute Leukemia/Lymphoma

NCT00214370
View directory record Official record
Conditions
Leukemia, Lymphoma
Interventions
Propofol-Fentanyl, Propofol alone
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
2 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Oct 22, 2026, 2:34 PM EDT
Not listed Phase 1Phase 2 Interventional

The Effectiveness of a Pediatric Lumbar Puncture Restraint Device

NCT00980070
View directory record Official record
Conditions
Indication for Lumbar Puncture
Interventions
Pediatric Restraint for Lumbar Puncture, Lumbar Puncture Device, Standard of Care
Device · Other
Lead sponsor
University of Nebraska
Other
Eligibility
1 Day to 90 Days
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 21, 2012 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Ultrasound vs Palpation for Infant Lumbar Puncture

NCT02373774
View directory record Official record
Conditions
Spinal; Puncture, Complications
Interventions
Ultrasound
Device
Lead sponsor
Columbia University
Other
Eligibility
Up to 90 Days
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Oct 22, 2026, 2:34 PM EDT
Completed No phase listed Observational

Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)

NCT00001206
View directory record Official record
Conditions
Attention Deficit and Disruptive Behavior Disorder, Attention Deficit Disorder With Hyperactivity
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
6 Years to 17 Years
Enrollment
347 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1985 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Oct 22, 2026, 2:34 PM EDT
Terminated No phase listed Observational

Pharmacokinetics of Systemic Anti-Cancer Therapies in the Cerebrospinal Fluid (CSF) of Patients With Advanced Cancer

NCT02580045
View directory record Official record
Conditions
Metastatic Cancer Patients on an Anti-cancer Therapy, Advanced Cancer, Brain Metastasis
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 28, 2018 · Synced Oct 22, 2026, 2:34 PM EDT
Terminated Phase 1 Interventional

Intrathecal Pertuzumab and Trastuzumab in Patients With New Untreated Asymptomatic or Low Symptomatic Brain Metastasis in HER2 Positive Breast Cancer

NCT02598427
View directory record Official record
Conditions
HER2 Positive Untreated Metastatic Breast Cancer, Asymptomatic or Low Symptomatic Brain Metastasis in Breast Cancer
Interventions
Pertuzumab, Trastuzumab
Drug
Lead sponsor
Kimberly Blackwell
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 28, 2018 · Synced Oct 22, 2026, 2:34 PM EDT
Terminated Not applicable Interventional

Ultrasound Guided Diagnostic Lumbar Puncture in Neurology

NCT03815045
View directory record Official record
Conditions
Lumbar Puncture
Interventions
Landmark-based lumbar puncture, Ultrasound-guided lumbar puncture
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 31, 2024 · Synced Oct 22, 2026, 2:34 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)

NCT03710278
View directory record Official record
Conditions
Meningitis, Encephalitis, Guillain-Barré, Subarachnoid Hemorrhage, Intracranial Neoplasm, Intracranial CNS Disorder
Interventions
LPat Device
Device
Lead sponsor
Spartanburg Regional Healthcare System
Other
Eligibility
12 Years and older
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Spartanburg, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Oct 22, 2026, 2:34 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Utility of Ultrasound-Guided Site Marking in Pediatric Lumbar Punctures

NCT04828746
View directory record Official record
Conditions
Ultrasound Therapy; Complications
Interventions
Ultrasound Guided Skin Marking
Procedure
Lead sponsor
Carilion Clinic
Other
Eligibility
Up to 17 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 7, 2022 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional Results available

Lumbar Puncture and Syphilis Outcome

NCT02031146
View directory record Official record
Conditions
Syphilis
Interventions
Lumbar puncture
Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 25, 2021 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Phase 4 Interventional Results available

"Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."

NCT00533468
View directory record Official record
Conditions
Pain
Interventions
Lidocaine Cream 4%, Placebo
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
0 Days to 60 Days
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Dec 28, 2022 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional

Patient Outcomes in Simulation Education (POISE) Intravenous (IV) and Lumbar Puncture (LP) Multi-institution Protocol

NCT01548547
View directory record Official record
Conditions
Infant Lumbar Puncture
Interventions
Simulation-based mastery learning
Other
Lead sponsor
Columbia University
Other
Eligibility
24 Years to 40 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 19, 2024 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Variability of Infant LP Insertion Site Based On Procedural Experience

NCT02949869
View directory record Official record
Conditions
Traumatic Lumbar Puncture
Interventions
Spinal Sonography
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 12 Months
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 1, 2018 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional

Virtual Reality as a Distraction Technique for Performing Lumbar Punctures in Children and Young Adu

NCT04092803
View directory record Official record
Conditions
Leukemia
Interventions
Virtual Reality
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
10 Years to 25 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 26, 2024 · Synced Oct 22, 2026, 2:34 PM EDT
Terminated Not applicable Interventional

Ultrasound Use for Difficult Lumbar Punctures in Pediatric Oncology Patients

NCT01643291
View directory record Official record
Conditions
Leukemia
Interventions
Ultrasound
Procedure
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
Not listed
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 5, 2015 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Phase 1 Interventional

Effect of Polyunsaturated Fatty Acids on Cardiovascular and Motor Responses Under Stress

NCT00014027
View directory record Official record
Conditions
Healthy
Interventions
Docosahexaenoic acid (DHA), Eicosapentaenoic acid
Drug
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Incidence of Headache Following an Unintentional Dural Puncture

NCT01977898
View directory record Official record
Conditions
Postdural Puncture Headache, Post-Lumbar Puncture Headache, Cerebrospinal Fluid Leaks
Interventions
Morphine, Saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 17, 2021 · Synced Oct 22, 2026, 2:34 PM EDT
Terminated No phase listed Observational

Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients

NCT02207647
View directory record Official record
Conditions
Meningoencephalitis, Other Syndromes Requiring Lumbar Puncture in Emergency Department
Interventions
no intervention
Other
Lead sponsor
Olive View-UCLA Education & Research Institute
Other
Eligibility
3 Months and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Sylmar, California
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Oct 22, 2026, 2:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Bedside Ultrasound Assistance on the Proportion of Successful Infant Spinal Taps

NCT02133066
View directory record Official record
Conditions
Traumatic Lumbar Puncture
Interventions
Bedside Ultrasound-Assisted Site Marking, Mindray M7 Ultrasound, Routine lumbar puncture
Procedure · Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Up to 6 Months
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 22, 2026, 2:34 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System

NCT01596127
View directory record Official record
Conditions
Leukemia, Lymphoid Malignancies, Metastatic Malignant Neoplasm to the Leptomeninges
Interventions
Intrathecal Rituximab
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
3 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 24, 2018 · Synced Oct 22, 2026, 2:34 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Collection of Cerebrospinal Fluid in Healthy Children

NCT01698229
View directory record Official record
Conditions
Late Infantile Neuronal Ceroid Lipofuscinosis, Batten Disease
Interventions
Group 1
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
2 Years to 8 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2016 · Synced Oct 22, 2026, 2:34 PM EDT