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ClinicalTrials.gov public records Last synced Oct 4, 2026, 9:11 PM EDT

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Showing 49–72 of 133 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lumbar Spinal Stenosis Clear all
Withdrawn Phase 1Phase 2 Interventional

Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion

NCT00810212
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
PLF with autograft, PLF with NeoFuse
Procedure · Biological
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2020 · Synced Oct 4, 2026, 9:11 PM EDT
Terminated Phase 4 Interventional Results available

Condition of Approval Study

NCT00517751
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
X-STOP PEEK
Device
Lead sponsor
Medtronic Spine LLC
Industry
Eligibility
50 Years and older
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
23
States / cities
Birmingham, Alabama • Tucson, Arizona • Campbell, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jan 2, 2018 · Synced Oct 4, 2026, 9:11 PM EDT
Not listed Phase 2 Interventional

Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine

NCT04066296
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Phase 2 Interventional

Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion

NCT00996073
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Lumbar Interbody Fusion with Autograft, Lumbar Interbody Fusion with NeoFuse
Biological
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
5
States / cities
Santa Monica, California • Greenwood Village, Colorado • Loveland, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2020 · Synced Oct 4, 2026, 9:11 PM EDT
Active, not recruiting Not applicable Interventional

Non-surgical Spinal Decompression Therapy and Outcomes

NCT06525896
View directory record Official record
Conditions
Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal, Intervertebral Disc Injury
Interventions
NSSD, Sham NSSD
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Stanford, California • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Not applicable Interventional Results available

OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion

NCT01873586
View directory record Official record
Conditions
Degenerative Changes, Stenosis, Spondylosis
Interventions
Posterolateral Fusion
Procedure
Lead sponsor
SeaSpine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Kenmore, New York
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Oct 4, 2026, 9:11 PM EDT
Suspended Phase 4 Interventional

Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion

NCT03745040
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Spondylolisthesis
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
Allina Health System
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
2
States / cities
Minneapolis, Minnesota • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Oct 4, 2026, 9:11 PM EDT
Completed No phase listed Observational

Cost Effectiveness of OMT for Chronic Low Back Pain

NCT03532230
View directory record Official record
Conditions
Lumbar Radiculopathy, Lesion of Sciatic Nerve, Left Lower Limb, Lesion of Sciatic Nerve, Right Lower Limb, Lumbar Spinal Stenosis, Lumbar Spondylosis, Lumbago With Sciatica, Left Side, Lumbago With Sciatica, Right Side
Interventions
Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 84 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
East Lansing, Michigan • Stratford, New Jersey • Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Phase 4 Interventional Results available

Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion

NCT00808665
View directory record Official record
Conditions
Spinal Fusion Acquired, Spinal Stenosis, Lesions of Lumbosacral Intervertebral Disc, Spinal Diseases
Interventions
Dexmedetomidine, 0.9% Saline
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 25, 2018 · Synced Oct 4, 2026, 9:11 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Predictors of Decompressive Laminectomy Outcomes

NCT02215551
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 90 Years
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2023
U.S. locations
7
States / cities
Denver, Colorado • Decatur, Georgia • Ann Arbor, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2023 · Synced Oct 4, 2026, 9:11 PM EDT
Completed No phase listed Observational Results available

Postmarket Outcomes Study for Evaluation of the Superion™ Spacer

NCT04563793
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Superion™ IDS
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
21 Years and older
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
23
States / cities
Fountain Valley, California • Larkspur, California • San Diego, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Phase 3 Interventional

Surgical Versus Nonsurgical Treatment for Spinal Stenosis

NCT00022776
View directory record Official record
Conditions
Spinal Stenosis
Interventions
Surgical decompression, Physical therapy
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2007
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2013 · Synced Oct 4, 2026, 9:11 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.

NCT06157177
View directory record Official record
Conditions
Sciatica Acute, Lumbar Spinal Stenosis
Interventions
Metaxalone 640 mg Oral Tablet
Drug
Lead sponsor
Primus Pharmaceuticals
Industry
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
24
States / cities
Auburn, Alabama • Valley Village, California • Aventura, Florida + 21 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Not applicable Interventional Results available

Efficacy and Safety of Accell Evo3 Demineralized Bone Matrix (DBM) in Instrumented Posterolateral Lumbar Spine Fusion

NCT01430299
View directory record Official record
Conditions
Stenosis, Spondylosis, Degenerative Changes
Interventions
Demineralized Bone Matrix, rh-BMP2
Device
Lead sponsor
SeaSpine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2018 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Phase 2 Interventional

Chiropractic Dosage for Lumbar Stenosis

NCT00527527
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
flexion distraction, placebo control
Procedure · Other
Lead sponsor
National University of Health Sciences
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 12, 2011 · Synced Oct 4, 2026, 9:11 PM EDT
Terminated Not applicable Interventional Results available

Clinical Outcomes of the Trinica(R) Anterior Lumbar Plate: Fixed Screws vs. Variable Screws

NCT00762723
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions
Trinica Anterior Lumbar Plate System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Daphne, Alabama • Mobile, Alabama • San Bernardino, California
Source: ClinicalTrials.gov public record
Updated Apr 17, 2014 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Not applicable Interventional

A Randomized, Equivalence Trial of Percutaneous Lumbar Adhesiolysis and Caudal Epidural Steroid Injections

NCT01053273
View directory record Official record
Conditions
Low Back Pain
Interventions
Caudal Epidural Injection, percutaneous adhesiolysis
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Phase 4 Interventional Results available

MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

NCT00956631
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Interlaminar Decompression
Procedure
Lead sponsor
Vertos Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
13
States / cities
Jonesboro, Arkansas • Los Angeles, California • Napa, California + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

NCT00405691
View directory record Official record
Conditions
Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
"TOPS System" - Total Posterior Arthroplasty Implant
Device
Lead sponsor
Impliant, Ltd.
Industry
Eligibility
40 Years to 75 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
16
States / cities
Beverly Hills, California • Daly City, California • New Haven, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated May 18, 2011 · Synced Oct 4, 2026, 9:11 PM EDT
Terminated Not applicable Interventional

Dynamic Stabilization for Lumbar Spinal Stenosis With Stabilimax NZ® Dynamic Spine Stabilization System

NCT00529997
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Stabilimax NZ® Dynamic Spine Stabilization System
Device
Lead sponsor
Applied Spine Technologies
Industry
Eligibility
21 Years and older
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
19
States / cities
Phoenix, Arizona • Los Angeles, California • Oceanside, California + 16 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2010 · Synced Oct 4, 2026, 9:11 PM EDT
Completed No phase listed Observational

Retrospective Modulus ALIF Study

NCT05566704
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Stenosis
Interventions
Modulus ALIF System
Device
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
123 participants
Timeline
2022 – 2024
U.S. locations
5
States / cities
Orange, California • San Diego, California • Atlanta, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 4, 2026, 9:11 PM EDT
Not listed Not applicable Interventional Results available

The MOTION Study - Treatment of LSS With the MILD Procedure

NCT03610737
View directory record Official record
Conditions
Spinal Stenosis, Lumbar Region, With Neurogenic Claudication
Interventions
MILD Procedure, Conventional Medical Management (CMM)
Device · Other
Lead sponsor
Vertos Medical, Inc.
Industry
Eligibility
50 Years to 80 Years
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
18
States / cities
Newport Beach, California • Colorado Springs, Colorado • Lakeland, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Not applicable Interventional Results available

MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

NCT01315145
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Percutaneous Lumbar Decompression, Epidural Steroid Injection
Procedure · Drug
Lead sponsor
Vertos Medical, Inc.
Industry
Eligibility
50 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
27
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Aptos, California + 24 more
Source: ClinicalTrials.gov public record
Updated Aug 31, 2015 · Synced Oct 4, 2026, 9:11 PM EDT
Completed Not applicable Interventional

Epidural Steroid Injection Versus Epidural Steroid Injection and Manual Physical Therapy and Exercise in the Management of Lumbar Spinal Stenosis

NCT00786981
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Epidural steroid injection plus physical therapy, Epidural steroid injection
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
50 Years to 90 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
4
States / cities
Denver, Colorado • Peoria, Illinois • Keesler Air Force Base, Mississippi + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Oct 4, 2026, 9:11 PM EDT