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ClinicalTrials.gov public records Last synced Oct 4, 2026, 10:00 PM EDT

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Showing 73–96 of 133 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lumbar Spinal Stenosis Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Return of Bowel Function After One or Two Level Anterior Lumbar Interbody Fusion With Chewing Gum

NCT03945461
View directory record Official record
Conditions
Spondylosis, Spondylolisthesis, Neurogenic Claudication, Foraminal Stenosis
Interventions
Chewing gum
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 26, 2024 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Phase 4 Interventional Results available

Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)

NCT01238536
View directory record Official record
Conditions
Spinal Stenosis, Low Back Pain
Interventions
Epidural steroid with local anesthetic injection, Epidural local anesthetic injection, Epidural steroid injection, Epidural local anesthetic injection
Procedure · Drug
Lead sponsor
University of Washington
Other
Eligibility
50 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
10
States / cities
Redwood City, California • Roseville, California • Denver, Colorado + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 13, 2017 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease

NCT03733626
View directory record Official record
Conditions
Lumbar Spondylolisthesis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Lumbar Radiculopathy, Lumbar Spinal Stenosis, Lumbar Disc Disease
Interventions
ViviGen® Cellular Bone Matrix with DePuy Synthes Spinal Pedicle screw system, Local Bone Autologous Bone Graft with DePuy Synthes Spinal pedicle screw system
Combination Product
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Not applicable Interventional

A Pivotal Study of the Premia Spine TOPS™ System

NCT03012776
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
Interventions
Total Posterior Spine System (TOPS), Transforaminal Lumbar Interbody Fusion (TLIF)
Device · Procedure
Lead sponsor
Premia Spine
Industry
Eligibility
35 Years to 80 Years
Enrollment
305 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
36
States / cities
Glendale, California • Los Angeles, California • Orange, California + 32 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Oct 4, 2026, 10:00 PM EDT
Completed No phase listed Observational

Magnetic Resonance Imaging (MRI) Interpretations for Lumbar Spinal Stenosis (LSS)

NCT01017692
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
MRI
Procedure
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
21 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 25, 2015 · Synced Oct 4, 2026, 10:00 PM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion

NCT03327272
View directory record Official record
Conditions
Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis, Myelopathy, Radiculopathy, Myeloradiculopathy
Interventions
Methylprednisolone, Saline
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 4, 2026, 10:00 PM EDT
Withdrawn Not applicable Interventional

Indirect vs. Direct Decompression for Treatment of Central Stenosis: RCT

NCT04708977
View directory record Official record
Conditions
Patients With Spinal Stenosis Indicated for LLIF
Interventions
One-level lateral lumbar interbody fusion with Indirect Decompression, One-level lateral lumbar interbody fusion with Direct Decompression
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Not applicable Interventional Results available

Accell Evo3™ Demineralized Bone Matrix in Instrumented Lumbar Spine Fusion

NCT02018445
View directory record Official record
Conditions
Degenerative Changes, Stenosis, Spondylosis
Interventions
Posterolateral Fusion
Procedure
Lead sponsor
SeaSpine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Not applicable Interventional

Optimizing Impact of Manual Therapy on Lumbar Spinal Stenosis

NCT06023498
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Manual Therapy and Exercise, Intramuscular Electroacupuncture
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Orlando, Florida • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Vertos Mild - Post Market Patient Outcomes

NCT01076244
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Minimally Invasive Lumbar Decompression
Procedure
Lead sponsor
The Center for Pain Relief, Inc.
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 2, 2013 · Synced Oct 4, 2026, 10:00 PM EDT
Not listed No phase listed Observational

The iO-Flex® Study: Evaluation of the Baxano iO-Flex® System for Decompressive Lumbar Surgery

NCT01067014
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Baxano iO-Flex® System
Device
Lead sponsor
Baxano Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
18
States / cities
Castro Valley, California • Los Angeles, California • Watsonville, California + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 23, 2013 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Not applicable Interventional

Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine

NCT02023372
View directory record Official record
Conditions
Intervertebral Disc Disease, Intervertebral Disc Degeneration, Spondylosis, Spondylolisthesis, Spinal Stenosis
Interventions
NuCel with Autograft
Other
Lead sponsor
NuTech Medical, Inc
Industry
Eligibility
21 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 4, 2026, 10:00 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Outcome Study of the Triad Allograft for Posterior Lumbar Fusion

NCT00205101
View directory record Official record
Conditions
Pain, Stenosis, Spondylolisthesis
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2009
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Oct 4, 2026, 10:00 PM EDT
Terminated Not applicable Interventional

Evaluation of Radiographic and Patient Outcomes Following Lumbar Spine Fusion Using Demineralized Bone Matrix (DBM) Mixed With Autograft

NCT00254852
View directory record Official record
Conditions
Stenosis, Spondylolisthesis, Degenerative Disc Disease
Interventions
Posterior Lateral Fusion (PLF), Anterior Lumbar Interbody Fusion (ALIF), Transforaminal lumbar interbody fusion (TLIF), Posterior lumbar interbody fusion (PLIF), Extreme lateral interbody fusion (XLIF)
Procedure
Lead sponsor
Exactech
Industry
Eligibility
21 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
6
States / cities
Long Beach, California • San Diego, California • New Hartford, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2013 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Phase 4 Interventional Results available

Efficacy of Pregabalin in Patients With Radicular Pain

NCT00908375
View directory record Official record
Conditions
Neuropathy; Radicular, Lumbar, Lumbosacral, Failed Back Surgery Syndrome, Spinal Stenosis, Herniated Disc
Interventions
Pregabalin, Sugar Pill
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 64 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 13, 2014 · Synced Oct 4, 2026, 10:00 PM EDT
Recruiting No phase listed Observational

The Prevalence of Directional Preference in the Lumbar Stenosis Population

NCT07007663
View directory record Official record
Conditions
Lumbar Stenosis
Interventions
Not listed
Lead sponsor
NYU Langone Health
Other
Eligibility
48 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Lake Success, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 4, 2026, 10:00 PM EDT
Terminated Not applicable Interventional Results available

Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery

NCT04007094
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylosis, Spondylolisthesis
Interventions
ViviGen Cellular Bone Matrix
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 24, 2024 · Synced Oct 4, 2026, 10:00 PM EDT
Completed No phase listed Observational

Misoprostol for Spinal Stenosis

NCT04611464
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Low Back Pain
Interventions
Misoprostol
Drug
Lead sponsor
Dallas VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Oct 4, 2026, 10:00 PM EDT
Not yet recruiting Not applicable Interventional

Activity Post Spinal Surgery Engagement Trial

NCT07825480
View directory record Official record
Conditions
Spinal Surgery for Lumbar Spinal Stenosis (LSS)
Interventions
Wrist based activity tracker wear, Basic Study Activities, Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
40 Years to 85 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 4, 2026, 10:00 PM EDT
Terminated Phase 3 Interventional Results available

A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis

NCT00697827
View directory record Official record
Conditions
Spinal Stenosis
Interventions
Interspinous Spacer device, Interspinous Process Distraction Device
Device
Lead sponsor
Synthes USA HQ, Inc.
Industry
Eligibility
50 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
10
States / cities
Santa Monica, California • New Haven, Connecticut • Minneapolis, Minnesota + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2012 · Synced Oct 4, 2026, 10:00 PM EDT
Enrolling by invitation No phase listed Observational

Lumbar Interbody Implant Study

NCT04418830
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis, Sagittal Deformity
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
1,050 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
16
States / cities
La Jolla, California • Los Alamitos, California • Merced, California + 13 more
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Not applicable Interventional Results available

Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

NCT02700451
View directory record Official record
Conditions
Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
Interventions
Ketorolac, Acetaminophen, Placebo
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 75 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Oct 4, 2026, 10:00 PM EDT
Completed Not applicable Interventional Results available

Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody Cages

NCT03647501
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Lumbar Spinal Deformity, Lumbar Spondylosis
Interventions
Interbody cage (titanium), Interbody cage (PEEK)
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 15, 2023 · Synced Oct 4, 2026, 10:00 PM EDT
Recruiting Not applicable Interventional

Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans

NCT06089746
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
NIPT
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
55 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 4, 2026, 10:00 PM EDT