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Showing 1–24 of 107 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lumbar Spine Stenosis Clear all
Recruiting Phase 3 Interventional

Tranexamic Acid in Adult Spinal Deformity Surgery

NCT03553186
View directory record Official record
Conditions
Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical
Interventions
Tranexamic Acid 100 MG/ML, Placebo
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Phase 4 Interventional Results available

Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion

NCT00808665
View directory record Official record
Conditions
Spinal Fusion Acquired, Spinal Stenosis, Lesions of Lumbosacral Intervertebral Disc, Spinal Diseases
Interventions
Dexmedetomidine, 0.9% Saline
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 24, 2018 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Phase 4 Interventional Results available

MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

NCT00956631
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Interlaminar Decompression
Procedure
Lead sponsor
Vertos Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
13
States / cities
Jonesboro, Arkansas • Los Angeles, California • Napa, California + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2013 · Synced Sep 27, 2026, 4:23 AM EDT
Completed No phase listed Observational

Post Epidural Steroid Injection Follow-up

NCT04207606
View directory record Official record
Conditions
Lumbago, Lumbar Spinal Stenosis, Lumbar Disc Herniation
Interventions
Post Epidural Steroid Injection Follow-up
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Timeline
2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Results available

MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

NCT01315145
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Percutaneous Lumbar Decompression, Epidural Steroid Injection
Procedure · Drug
Lead sponsor
Vertos Medical, Inc.
Industry
Eligibility
50 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
27
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Aptos, California + 24 more
Source: ClinicalTrials.gov public record
Updated Aug 30, 2015 · Synced Sep 27, 2026, 4:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Chiropractic Distraction Spinal Manipulation- Lumbar Stenosis Study

NCT03863769
View directory record Official record
Conditions
Spinal Stenosis Lumbar
Interventions
Lumbar Spinal Stenosis
Other
Lead sponsor
Parker University
Other
Eligibility
48 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Sep 27, 2026, 4:23 AM EDT
Not yet recruiting Not applicable Interventional

VR-Cognitive Behavioral Therapy Prehabilitation for Spinal Deformity Surgery

NCT07777679
View directory record Official record
Conditions
Degenerative Spine Disease, Spinal Stenosis Lumbar
Interventions
Virtual Reality-Based CBT Prehabilitation (VR-CBT), CBT Prehabilitation without Virtual Reality
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Irvine, California • Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Enrolling by invitation No phase listed Observational

Lumbar Interbody Implant Study

NCT04418830
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Scoliosis, Spinal Stenosis, Sagittal Deformity
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
1,050 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
16
States / cities
La Jolla, California • Los Alamitos, California • Merced, California + 13 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine

NCT01968993
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions
nanOss Bioactive - posterolateral gutter
Device
Lead sponsor
Pioneer Surgical Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
3
States / cities
La Jolla, California • San Francisco, California • Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Sep 27, 2026, 4:23 AM EDT
Completed No phase listed Observational

Magnetic Resonance Imaging (MRI) Interpretations for Lumbar Spinal Stenosis (LSS)

NCT01017692
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
MRI
Procedure
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
21 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 24, 2015 · Synced Sep 27, 2026, 4:23 AM EDT
Suspended Phase 4 Interventional

Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion

NCT03745040
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Spondylolisthesis
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
Allina Health System
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
2
States / cities
Minneapolis, Minnesota • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

A Randomized, Equivalence Trial of Percutaneous Lumbar Adhesiolysis and Caudal Epidural Steroid Injections

NCT01053273
View directory record Official record
Conditions
Low Back Pain
Interventions
Caudal Epidural Injection, percutaneous adhesiolysis
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Results available

Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody Cages

NCT03647501
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Lumbar Spinal Deformity, Lumbar Spondylosis
Interventions
Interbody cage (titanium), Interbody cage (PEEK)
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 14, 2023 · Synced Sep 27, 2026, 4:23 AM EDT
Withdrawn Not applicable Interventional

Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial

NCT06579391
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Essential amino acids, Alanine
Dietary Supplement
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Results available

Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

NCT02700451
View directory record Official record
Conditions
Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
Interventions
Ketorolac, Acetaminophen, Placebo
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 75 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Sep 27, 2026, 4:23 AM EDT
Recruiting Not applicable Interventional

Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman Device

NCT06355791
View directory record Official record
Conditions
Degenerative Conditions of the Lumbar Spine, Lumbar Spinal Stenosis, Spondylolisthesis
Interventions
Minuteman G5 Device
Device
Lead sponsor
Spinal Simplicity LLC
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
6
States / cities
Newnan, Georgia • Indianapolis, Indiana • Kansas City, Kansas + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Sep 27, 2026, 4:23 AM EDT
Completed No phase listed Observational

Cost Effectiveness of OMT for Chronic Low Back Pain

NCT03532230
View directory record Official record
Conditions
Lumbar Radiculopathy, Lesion of Sciatic Nerve, Left Lower Limb, Lesion of Sciatic Nerve, Right Lower Limb, Lumbar Spinal Stenosis, Lumbar Spondylosis, Lumbago With Sciatica, Left Side, Lumbago With Sciatica, Right Side
Interventions
Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 84 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
East Lansing, Michigan • Stratford, New Jersey • Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Sep 27, 2026, 4:23 AM EDT
Withdrawn No phase listed Observational

Radiation Exposure Reduction Protocol for Minimally Invasive Lumbar Decompression (mild) Techniques

NCT06651138
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Radiation Exposure
Interventions
Fluoroscopy
Radiation
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 20, 2024 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

Physical Activity Intervention for Patients Following Lumbar Spine Surgery

NCT04591249
View directory record Official record
Conditions
Spinal Degenerative Disorder, Spinal Stenosis, Spondylosis
Interventions
Physical activity intervention, Usual care
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 27, 2026, 4:23 AM EDT
Active, not recruiting Not applicable Interventional

A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)

NCT04192591
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Superion™ IDS device
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
45 Years and older
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2041
U.S. locations
23
States / cities
Carlsbad, California • Larkspur, California • Rancho Mirage, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Pivotal Study of a Facet Replacement System to Treat Spinal Stenosis

NCT00401518
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Non-randomized ACADIA® Facet Replacement System, Randomized ACADIA® Facet Replacement System, Randomized Instrumented posterolateral fusion (PLF)
Device
Lead sponsor
Globus Medical Inc
Industry
Eligibility
21 Years to 85 Years
Enrollment
390 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2017
U.S. locations
28
States / cities
Beverly Hills, California • Los Angeles, California • Rancho Mirage, California + 23 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2020 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional

Physical Therapy Treatments, Including Neural Mobilization and Hip/Back Stretches for People Between 50-89 With Lumbar Spinal Stenosis and Leg Pain Provoked by Walking

NCT03368638
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Physical therapy intervention
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
50 Years to 89 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Amarillo, Texas
Source: ClinicalTrials.gov public record
Updated Jan 24, 2021 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Phase 4 Interventional Results available

Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis

NCT00995371
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
MILD® (Minimally Invasive Lumbar Decompression), Epidural Steroid Injection
Device · Drug
Lead sponsor
Coastal Orthopedics & Sports Medicine
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Bradenton, Florida
Source: ClinicalTrials.gov public record
Updated Nov 14, 2013 · Synced Sep 27, 2026, 4:23 AM EDT
Completed Not applicable Interventional Results available

Comparative Study of Sham Versus Mild® Procedure in Patients Diagnosed With Symptomatic Lumbar Central Canal Stenosis

NCT01129921
View directory record Official record
Conditions
Lumbar Spine Stenosis Central Canal
Interventions
Percutaneous Lumbar Decompression, Sham lumbar decompression
Device
Lead sponsor
Napa Pain Institute
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Napa, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2013 · Synced Sep 27, 2026, 4:23 AM EDT