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ClinicalTrials.gov public records Last synced Sep 6, 2026, 2:29 PM EDT

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Showing 1–24 of 107 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lung Nodule Clear all
Completed No phase listed Observational Accepts healthy volunteers

Retrospective Clinical Trial Comparing Radiologists' Diagnosis Accuracy in Lung Cancer Screening Population With and Without the Help of an AI/ML Tech-based SaMD

NCT06751576
View directory record Official record
Conditions
High Risk Cancer, Lung Cancer
Interventions
Median LCS
Device
Lead sponsor
Median Technologies
Industry
Eligibility
50 Years to 80 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
3
States / cities
Philadelphia, Pennsylvania • Memphis, Tennessee • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 5, 2025 · Synced Sep 6, 2026, 2:29 PM EDT
Terminated Not applicable Interventional

Evaluation of the Archimedes™ System for Transparenchymal Nodule Access

NCT02460120
View directory record Official record
Conditions
Lung Cancer
Interventions
Archimedes System
Device
Lead sponsor
Broncus Medical Inc
Industry
Eligibility
21 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jan 26, 2017 · Synced Sep 6, 2026, 2:29 PM EDT
Active, not recruiting Not applicable Interventional

Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules

NCT04574518
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Tobacco Use
Interventions
TeaM OUT Intervention, Enhanced Usual Care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Minneapolis, Minnesota • Portland, Oregon • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Not applicable Interventional

The Watch the Spot Trial

NCT02623712
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Coin Lesion, Pulmonary, Lung Neoplasms, Carcinoma, Non-small-cell Lung
Interventions
More Frequent Surveillance Strategy, Less Frequent Surveillance Strategy
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
35 Years and older
Enrollment
34,686 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Sep 6, 2026, 2:29 PM EDT
Not listed No phase listed Observational

Cone Beam CT Guided Robotic Navigational Bronchoscopy

NCT05358041
View directory record Official record
Conditions
Lung Nodule, Lung Mass, Lung Cancer
Interventions
Robotic Bronchoscopy
Device
Lead sponsor
Columbus Regional Health
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Columbus, Indiana
Source: ClinicalTrials.gov public record
Updated May 2, 2022 · Synced Sep 6, 2026, 2:29 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Care Pathway for Patients Undergoing VATS Lobectomy or Segmentectomy

NCT03024294
View directory record Official record
Conditions
VATS Lobectomy, VATS Segmentectomy, Care Pathway, Lung Nodule
Interventions
Post-operative care pathway for patients undergoing VATS lobectomy or segmentectomy
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 15, 2018 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

Pilot Study of Navigational Bronchoscopy and Transthoracic Needle Biopsy

NCT02109458
View directory record Official record
Conditions
Peripheral Pulmonary Nodules
Interventions
Navigation guided bronchoscopy
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 99 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 23, 2017 · Synced Sep 6, 2026, 2:29 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Specimens for Lung Cancer Panel Design

NCT07401797
View directory record Official record
Conditions
Lung Nodules
Interventions
Not listed
Lead sponsor
Maverix Medical
Industry
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 6, 2026, 2:29 PM EDT
Not listed Not applicable Interventional

MDCT vs. CBCT Guided Percutaneous Lung Nodule Biopsy: A Comparison of Pneumothorax Incidence and Associated Risk Factors

NCT05344430
View directory record Official record
Conditions
Lung Diseases
Interventions
cone beam computed tomography (CBCT) for percutaneous transthoracic needle biopsy
Procedure
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Port Jefferson, New York
Source: ClinicalTrials.gov public record
Updated May 15, 2023 · Synced Sep 6, 2026, 2:29 PM EDT
Not yet recruiting No phase listed Observational

ICARE-LCS QUERI Partnered Evaluation Initiative: Integrating Comprehensive Tobacco Treatment to Enhance Lung Cancer Screening

NCT06745258
View directory record Official record
Conditions
Tobacco Dependence Treatment, Lung Cancer Screening
Interventions
External Facilitation
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Sep 6, 2026, 2:29 PM EDT
Recruiting Not applicable Interventional

Image Guided VATS vs. VATS Resection

NCT03623958
View directory record Official record
Conditions
Lung Cancer
Interventions
Image guided Video-Assisted Thoracic Surgery (VATS) resection, Video-Assisted Thoracic Surgery
Device · Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 6, 2026, 2:29 PM EDT
Not listed Not applicable Interventional

Clinical Utility for Ion Endoluminal System

NCT03893539
View directory record Official record
Conditions
Pulmonary Nodule, Lung Cancer, Lung Diseases
Interventions
Ion Endoluminal System™
Device
Lead sponsor
Intuitive Surgical
Industry
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
6
States / cities
Boston, Massachusetts • Detroit, Michigan • Rochester, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2024 · Synced Sep 6, 2026, 2:29 PM EDT
Completed No phase listed Observational Results available

A Multi-Center Trial of the ProLung Test™

NCT01566682
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
Not listed
Lead sponsor
Fresh Medical Laboratories
Industry
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
15
States / cities
Los Angeles, California • San Diego, California • Stanford, California + 12 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Sep 6, 2026, 2:29 PM EDT
Active, not recruiting No phase listed Observational

Evaluating the Real World Performance of an AI Based Lung Nodule Detection Tool

NCT06597968
View directory record Official record
Conditions
Lung Nodule
Interventions
AI Based CAD Software (qXR-Ln)
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
44,900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 6, 2026, 2:29 PM EDT
Completed Phase 1 Interventional

Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors

NCT00413322
View directory record Official record
Conditions
Tumor
Interventions
belinostat, 5-Fluorouracil (5-FU)
Drug
Lead sponsor
Valerio Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
3
States / cities
Scottsdale, Arizona • Omaha, Nebraska • Portsmouth, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 7, 2015 · Synced Sep 6, 2026, 2:29 PM EDT
Completed No phase listed Observational

3-D Reconstruction of CT Scan Images in the Evaluation of Non-Specific Pulmonary Nodules

NCT00613041
View directory record Official record
Conditions
Undiagnosed Pulmonary Nodules, Lung Nodules
Interventions
CT Scan
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Sep 6, 2026, 2:29 PM EDT
Completed No phase listed Observational

A Registry to Evaluate the Performance of the BDX-XL2 Test

NCT03766958
View directory record Official record
Conditions
Nodule Solitary Pulmonary, NSCLC
Interventions
Not listed
Lead sponsor
Biodesix, Inc.
Industry
Eligibility
40 Years and older
Enrollment
842 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
15
States / cities
Sun City, Arizona • Northridge, California • Pueblo, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Sep 6, 2026, 2:29 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

SPARC - Screening for Lung Cancer With Platelets Via an AI-enabled RNA-based Classifier

NCT07460440
View directory record Official record
Conditions
Lung Cancer, Lung Nodule
Interventions
Platelet RNA-based assay
Diagnostic Test
Lead sponsor
University of Utah
Other
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 6, 2026, 2:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

GE Healthcare VolumeRAD Lung Nodule Detection Study

NCT00963651
View directory record Official record
Conditions
Pulmonary Nodule, Solitary, Multiple Pulmonary Nodules
Interventions
Chest tomosynthesis and X-ray
Device
Lead sponsor
American College of Radiology - Image Metrix
Industry
Eligibility
18 Years and older
Enrollment
187 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
3
States / cities
Ann Arbor, Michigan • Durham, North Carolina • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 23, 2013 · Synced Sep 6, 2026, 2:29 PM EDT
Active, not recruiting No phase listed Observational

Biomarkers for Diagnosis of Lung Nodules

NCT01085864
View directory record Official record
Conditions
Lung Abscess
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 85 Years
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 6, 2026, 2:29 PM EDT
Completed No phase listed Observational

Transbronchial Biopsy Assisted by Robot Guidance in the Evaluation of Tumors of the Lung

NCT04182815
View directory record Official record
Conditions
Pulmonary Nodule, Lung Cancer
Interventions
Robotic assisted bronchoscopy
Device
Lead sponsor
Auris Health, Inc.
Industry
Eligibility
21 Years and older
Enrollment
691 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
17
States / cities
Scottsdale, Arizona • Encinitas, California • Rancho Mirage, California + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Sep 6, 2026, 2:29 PM EDT
Terminated Not applicable Interventional Results available

Needle-Based Confocal Laser Endomicroscopy for Diagnosis of Lung Cancer in Patients With Peripheral Pulmonary Nodules

NCT05556525
View directory record Official record
Conditions
Lung Carcinoma
Interventions
Fluorescein, Image-Guided Needle Confocal Laser Endomicroscopy, Ultrasound-Guided Transbronchial Needle Aspiration
Other · Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 6, 2026, 2:29 PM EDT
Completed No phase listed Observational

A Multicenter Study to Evaluate the Cios Spin and the Ion Endoluminal System for Pulmonary Nodule Biopsy

NCT05562895
View directory record Official record
Conditions
Lung Cancer
Interventions
Ion Endoluminal System and Cios Spin
Device
Lead sponsor
Intuitive Surgical
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
6
States / cities
Birmingham, Alabama • San Diego, California • Rochester, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced Sep 6, 2026, 2:29 PM EDT
Terminated Not applicable Interventional

Cryobiopsy Versus Forceps Biopsy for Pulmonary Lesions

NCT02983903
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
transbronchial biopsy
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Sep 6, 2026, 2:29 PM EDT