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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lymphedema, Secondary Clear all
Terminated Phase 1Phase 2 Interventional Results available

Recombinant Human Hyaluronidase in Treating Lymphedema in Patients With Cancer

NCT01928030
View directory record Official record
Conditions
Lymphedema, Malignant Neoplasm
Interventions
recombinant human hyaluronidase
Biological
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Jun 10, 2026, 10:30 AM EDT
Active, not recruiting No phase listed Observational

Imaging Sodium and Lymphatics in Lymphedema

NCT05242900
View directory record Official record
Conditions
Lymphedema of Leg, Lymphedema, Secondary, Lymphedema Related Fibrosis
Interventions
Complete decongestive therapy, Standard imaging protocol
Procedure · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Jun 10, 2026, 10:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Skin Biophysical Measures for Assessing Head and Neck Cancer-Related External Lymphedema

NCT04457375
View directory record Official record
Conditions
Lymphedema, Secondary
Interventions
TDC
Diagnostic Test
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional

Complete Decongestive Therapy on Head and Neck Lymphedema

NCT04045860
View directory record Official record
Conditions
Lymphedema of Face, Secondary Lymphedema
Interventions
Complete Decongestive Therapy, Observation
Procedure · Other
Lead sponsor
Our Lady of the Lake Hospital
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 7, 2021 · Synced Jun 10, 2026, 10:30 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

LYT-100 in Patients With BCRL

NCT04243837
View directory record Official record
Conditions
Breast Cancer Related Lymphoedema, Lymphoedema
Interventions
LYT-100 BCRL, Placebo BCRL
Drug
Lead sponsor
PureTech
Industry
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
4
States / cities
Duarte, California • Los Angeles, California • Maitland, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Jun 10, 2026, 10:30 AM EDT
Terminated No phase listed Observational

CVR Registry Evaluating Flexitouch Plus and Conservative Care vs Conservative Care Only for Treatment of Lymphedema

NCT04116099
View directory record Official record
Conditions
Lymphedema
Interventions
Conservative care, Flexitouch Plus
Other · Device
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
3
States / cities
Glen Burnie, Maryland • Greenbelt, Maryland • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Jun 10, 2026, 10:30 AM EDT
Completed No phase listed Observational

Impact of Secondary Lymphedema on Symptoms, Functional Status, and Quality of Life After Treatment in Patients With Head and Neck Cancer

NCT01098669
View directory record Official record
Conditions
Cancer Survivor, Head and Neck Cancer, Lymphedema
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Jun 10, 2026, 10:30 AM EDT
Terminated No phase listed Observational

Quality of Life Changes on Lower Extremity Lymphedema Patients Using an Advanced Pneumatic Compression Device (PCD)

NCT02661646
View directory record Official record
Conditions
Lymphedema
Interventions
Advanced Pneumatic Compression Device
Device
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
6
States / cities
Baltimore, Maryland • East Orange, New Jersey • Brooklyn, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2023 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Complete Decongestive Therapy With Negative Pressure for Lipedema and Lymphedema Therapy

NCT03634462
View directory record Official record
Conditions
Lipedema, Secondary Lymphedema
Interventions
CDT with graded negative pressure
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
14 Years to 90 Years · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 18, 2020 · Synced Jun 10, 2026, 10:30 AM EDT
Active, not recruiting No phase listed Observational

Screening For BCRL In Targeted Therapy For Breast Cancer

NCT05142800
View directory record Official record
Conditions
Lymphedema, Lymphedema Arm, Lymphedema of Upper Arm, Lymphedema of Upper Limb, Lymphedema of the Hands, Edema, Edema Arm, Breast Cancer Lymphedema, Breast Cancer Metastatic, Breast Cancer Stage, Breast Cancer
Interventions
Perometer, SOZO device
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Jun 10, 2026, 10:30 AM EDT
Terminated Not applicable Interventional

Identification of a Screening Tool and Treatment of Lymphedema Secondary to the Management of Breast Cancer Study

NCT00282529
View directory record Official record
Conditions
Breast Cancer, Lymphedema
Interventions
High Risk Lymphedema Education and Device Intervention
Device
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 23, 2017 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional Results available

Imaging Biomarkers of Lymphatic Dysfunction

NCT03760744
View directory record Official record
Conditions
Secondary Lymphedema
Interventions
CDT with Negative Pressure, CDT alone
Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
30 Years to 90 Years · Female only
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional Results available

A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema

NCT04797390
View directory record Official record
Conditions
Lymphedema, Lymphedema of Face, Lymphedema, Secondary, Lymphedema Due to Radiation, Lymphedema; Surgical
Interventions
Advanced Pneumatic Compression Device (APCD), Usual Care
Device · Other
Lead sponsor
Tactile Medical
Industry
Eligibility
18 Years and older
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
10
States / cities
Birmingham, Alabama • Chicago, Illinois • Louisville, Kentucky + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional Results available

Treatment of Breast Cancer-related Lymphedema With a Negative Pressure Device

NCT03252145
View directory record Official record
Conditions
Lymphedema, Secondary, Lymphedema of Upper Limb
Interventions
PhysioTouch, Manual Lymph Drainage (MLD)
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Jun 10, 2026, 10:30 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders

NCT02156115
View directory record Official record
Conditions
Lymphangiomatosis, Lymphedema, Lymphangiectasia, Pulmonary Lymphangiectasia
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
2 Years to 90 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 10, 2024 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional Results available

Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema

NCT01079299
View directory record Official record
Conditions
Lymphedema
Interventions
Intermittent, gradient, pneumatic compression device
Device
Lead sponsor
Calvary Hospital, Bronx, NY
Other
Eligibility
21 Years to 95 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 9, 2012 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional Results available

Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema

NCT04897035
View directory record Official record
Conditions
Lymphedema, Lymphedema Lower Extremity, Chronic Venous Insufficiency, Secondary Lymphedema
Interventions
Dayspring Active Wearable Compression System
Device
Lead sponsor
Koya Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Los Altos, California • Morgan Hill, California
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional

Prevention of Lymphedema Among Breast Cancer Patients Through Implementation of an Integrative Therapy Program (ITP)

NCT02528539
View directory record Official record
Conditions
Lymphedema
Interventions
ITP
Other
Lead sponsor
Huntington Memorial Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Jun 10, 2026, 10:30 AM EDT
Recruiting Phase 2 Interventional

IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal Metastases

NCT06092892
View directory record Official record
Conditions
Breast Cancer, Axillary Nodal Disease, Female Breast Cancer, Axilla; Breast, Mastectomy; Lymphedema, Tumor, Breast
Interventions
Breast Surgery (BCS or mastectomy) with TAD/SNB, Adjuvant Radiation Therapy
Procedure · Radiation
Lead sponsor
Alice Chung
Other
Eligibility
45 Years and older · Female only
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
3
States / cities
Los Angeles, California • Pasadena, California • Tarzana, California
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jun 10, 2026, 10:30 AM EDT
Completed Not applicable Interventional

A Preference Study of Two Pneumatic Compression Devices for Patients With Lower Limb Lymphedema

NCT05485454
View directory record Official record
Conditions
Lymphedema of Leg, Lymphedema, Lymphedema, Secondary, Lymphedema Primary, Lymphedema, Lower Limb
Interventions
Aria Health Aria Free, A Traditional PCD
Device
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Jun 10, 2026, 10:30 AM EDT