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Conditions: Breast Carcinoma, Lymphedema
Interventions: Best Practice, Motivational Interviewing, Quality-of-Life Assessment, Questionnaire Administration; Other · Behavioral
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 21 Years and older · Female only
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Duarte, California

Conditions: Head and Neck Lymphedema
Interventions: FT-CC and Swallow Exercises, Swallow Exercises; Device · Other
Lead sponsor: Tactile Medical; Industry
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Lymphedema
Interventions: Aquatic Exercise arm; Behavioral
Lead sponsor: Baylor Research Institute; Other
Eligibility: 21 Years to 90 Years
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Lymphedema Arm
Interventions: BioBridge; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2029
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Lymphedema, Surgery, Breast Cancer
Interventions: OnLume Imaging System, Indocyanine green; Device · Drug
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older · Female only
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Lymphedema
Interventions: Exercise, Elevation, and Compression Garment, E0650 PCD with non-sequential waveform, E0651 PCD with sequential, non-gradient waveform, E0652 PCD with sequential, gradient waveform, E0652 PCD with peristaltic pulse waveform; Other · Device
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Waltham, Massachusetts

Conditions: Cancer of the Breast
Interventions: Axillary Reverse Mapping; Procedure
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Breast Cancer, Lymphedema
Interventions: bevacizumab; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Lymphedema
Interventions: Indocyanine Green; Drug
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 85 Years · Female only
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Breast Cancer
Interventions: questionnaire administration, survey administration, quality-of-life assessment; Other · Procedure
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years to 120 Years · Female only
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 3
States / cities: Nashville, Tennessee

Conditions: Lymphedema, Lymphedema Arm, Lymphedema of Upper Arm, Breast Cancer, Breast Carcinoma, Female Breast Cancer
Interventions: Immediate Lymphatic Reconstruction, Volumetric arm measurements, Lymphatic massage, Range of motion exercises, Compression garment use; Procedure · Diagnostic Test · Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 285 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2030
U.S. locations: 7
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

Conditions: Lymphedema Arm
Interventions: Lumason, Optison, Definity; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older · Female only
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Breast Cancer, Hereditary Breast/Ovarian Cancer (brca1, brca2), Acquired Lymphedema, Congenital Lymphedema
Interventions: Perforator Flap Breast Reconstruction, Vascularized Lymph Node Transfer; Procedure
Lead sponsor: The National Institute of Lymphology; Industry
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 3
States / cities: Chicago, Illinois • New Orleans, Louisiana • Charleston, South Carolina

Conditions: Secondary Lymphedema
Interventions: CDT with Negative Pressure, CDT alone; Procedure
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 30 Years to 90 Years · Female only
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Head and Neck Cancer, Lymphedema of the Head and Neck
Interventions: LTU-904 Portable Laser Therapy Unit (active laser device), LTU-904 Portable Laser Therapy Unit (sham/inactive laser device); Device
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Nashville, Tennessee

Conditions: Lymphedema
Interventions: Tourniquet Use; Procedure
Lead sponsor: OrthoCarolina Research Institute, Inc.; Other
Eligibility: 18 Years and older · Female only
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2025
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Charlotte, North Carolina

Conditions: Obesity, Breast Cancer
Interventions: Not listed
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years to 70 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Lymphedema
Interventions: Indocyanine Green (ICG), Near-infrared Fluorescence Lymphatic Imaging (NIRFLI); Drug · Device
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older · Female only
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Breast Cancer
Interventions: Axillary lymph node dissection (ALND), Axillary radiotherapy (ART); Procedure
Lead sponsor: University Hospital, Basel, Switzerland; Other
Eligibility: 18 Years and older
Enrollment: 1,060 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2037
U.S. locations: 4
States / cities: Bethesda, Maryland • Durham, North Carolina • Philadelphia, Pennsylvania + 1 more

Conditions: Cancer Survivor, Head and Neck Cancer, Lymphedema
Interventions: Not listed
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 2
States / cities: Nashville, Tennessee

Conditions: Lymphedema, Breast Cancer
Interventions: arm circumference measurement, Bioimpedance spectroscopy; Procedure · Device
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Breast Cancer
Interventions: Bioimpedance Spectroscopy; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Lipedema, Secondary Lymphedema
Interventions: CDT with graded negative pressure; Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 14 Years to 90 Years · Female only
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Lymphedema, Fibrosis
Interventions: Pravastatin, Pentoxifylline, Tocopherol; Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 295 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: Houston, Texas

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Remotivation Process for Improving Adherence to Lymphedema Treatment Programs in Patients With Breast Cancer-Related Lymphedema

Determining Swallow Outcomes in Head & Neck Lymphedema Subjects Receiving Early Intervention With Pneumatic Compression

Aquatic Exercise Study for Breast Cancer Patients With Lymphedema

Evaluation of Combination Therapy for Upper Extremity Lymphedema

Intraoperative Evaluation of Axillary Lymphatics

Pneumatic Compression Treatment For Upper Extremity Acquired Lymphedema

Axillary Reverse Mapping

A Pilot Study of VEGF Inhibition in Patients With Lymphedema Following Breast Cancer Treatment

Effect of Exercise on Indocyanine Green (ICG) Lymphography Imaging

Self-Care for Lymphedema in Patients With Breast Cancer

A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer

Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema

Outcomes After Perforator Flap Reconstruction for Breast Reconstruction and/or Lymphedema Treatment

Imaging Biomarkers of Lymphatic Dysfunction

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

Lymphedema Following Hand/Wrist Surgery in Women Post Axillary Node Dissection

BCRL Prevention Pilot

Lymphatic and Systemic Immunity Changes in Post-radiation Lymphedema Development

Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

Impact of Secondary Lymphedema on Symptoms, Functional Status, and Quality of Life After Treatment in Patients With Head and Neck Cancer

Arm Circumference Measurement With or Without Bioimpedance Spectroscopy in Finding Lymphedema Early in Patients With Stage I-III Breast Cancer

Evaluation of BIS for Quantification of Lymphedema

Complete Decongestive Therapy With Negative Pressure for Lipedema and Lymphedema Therapy

Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)