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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: MSM Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

PrEP Point-of-Care Brief-Intervention for Adherence Among Young Men Who Have Sex With Men

NCT05353283
View directory record Official record
Conditions
Risk Reduction
Interventions
Motivational Interviewing Counselling, Point-of-care Urine Tenofovir Measurement
Behavioral · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mhealth for PrEP Adherence by Young Adult MSM, Phase 2

NCT04633200
View directory record Official record
Conditions
Hiv
Interventions
DOT mobile app
Other
Lead sponsor
Environment and Health Group, Inc.
Industry
Eligibility
18 Years to 35 Years · Male only
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 27, 2023 · Synced Sep 12, 2026, 4:56 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Getting to Zero Among HHI MSM in the American South

NCT05075967
View directory record Official record
Conditions
HIV Infections
Interventions
Health Access Coalitions, Social Media, Peer Support, Promoting Human Autonomy Support & Empathy (PHASE)
Behavioral
Lead sponsor
HIV Prevention Trials Network
Network
Eligibility
15 Years and older · Male only
Enrollment
2,700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Connect 'n Unite: Couples-Based HIV/STI Prevention for Drug-Involved, Black MSM

NCT01394900
View directory record Official record
Conditions
HIV, Sexually Transmitted Infections
Interventions
CNU Intervention, WP Intervention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Male only
Enrollment
424 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intervention to Enhance PrEP Uptake and Adherence in a Community-Based Setting

NCT02037594
View directory record Official record
Conditions
Human Immunodeficiency Virus (HIV)
Interventions
Sexual Health Counseling, Enhanced Adherence Intervention, PrEP Information (Active Control), Standard of Care Adherence Support (Active Control)
Behavioral
Lead sponsor
Hunter College of City University of New York
Other
Eligibility
18 Years and older · Male only
Enrollment
438 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Results available

Tough Talks: A Disclosure Intervention for HIV+ Young Men Who Have Sex With Men (YMSM)

NCT03414372
View directory record Official record
Conditions
Hiv, HIV/AIDS, Disclosure
Interventions
Tough Talks Online, Tough Talks Clinic, Standard of Care
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 29 Years · Male only
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Multilevel Gaming Intervention for Persons on PrEP

NCT02611362
View directory record Official record
Conditions
MSM, PrEP, HIV Risk
Interventions
IMB Gaming Intervention
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older · Male only
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional

HIV Prevention and Trauma Treatment in Men Who Have Sex With Men and Who Have a History of Sexual Abuse

NCT00797654
View directory record Official record
Conditions
Risk Reduction
Interventions
Information-motivation-behavior skills and cognitive processing therapy, Pre and Post HIV-Test Counseling
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
18 Years and older · Male only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 8, 2016 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ADAPT-POL: Planned Parenthood Center of El Paso Adopting and Demonstrating the Adaptation of Prevention Techniques

NCT00252083
View directory record Official record
Conditions
HIV Infections
Interventions
Popular Opinion Leader
Behavioral
Lead sponsor
Centers for Disease Control and Prevention
Federal
Eligibility
18 Years and older · Male only
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2012 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing an Online Mindfulness-based Intervention to Reduce Minority Stress and HIV Risk Among Young Adult MSM - Aim 3

NCT05855655
View directory record Official record
Conditions
Hiv, Minority Stress, Mental Health Wellness 1
Interventions
Mindfulness-Based Queer Resilience (MBQR)
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 34 Years · Male only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Social Capital and Engagement in Care Among Young Black Men Who Have Sex With Men Living With HIV

NCT03664817
View directory record Official record
Conditions
HIV Infections
Interventions
social capital intervention, group-based health promotion intervention
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 29 Years · Male only
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Phase 2 Interventional

Behavior Change and Maintenance Intervention for HIV+ MSM Methamphetamine Users

NCT00432926
View directory record Official record
Conditions
HIV Infections, Substance Abuse, Sexually Transmitted Diseases
Interventions
EDGE counseling, no maintenance, EDGE counseling, plus maintenance, Attention control
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Male only
Enrollment
429 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Study of a Multi-Component Intervention for Black Men Who Have Sex With Men

NCT00951249
View directory record Official record
Conditions
HIV Infections
Interventions
Referral of Partners, Screening for STIs and counseling, Peer health care system navigators, Enhanced counseling
Behavioral
Lead sponsor
HIV Prevention Trials Network
Network
Eligibility
18 Years and older · Male only
Enrollment
1,553 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
8
States / cities
Los Angeles, California • San Francisco, California • Washington D.C., District of Columbia + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2022 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Phase 2 Interventional

Extended-Release Naltrexone to Treat Methamphetamine Dependence in Men Who Have Sex With Men (MSM)

NCT01449565
View directory record Official record
Conditions
Amphetamine-Related Disorders
Interventions
Naltrexone, Placebo
Drug
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years to 65 Years · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Advancing HIV Prevention and Linkage to Care Among MSM With Gamification

NCT02946164
View directory record Official record
Conditions
HIV Infections, Sexually Transmitted Diseases
Interventions
Stick To It
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years to 26 Years · Male only
Enrollment
166 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Los Angeles, California • Oakland, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2018 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Increasing PrEP Use in High-Risk Social Networks of African-American MSM in Underserved Low-Risk Cities

NCT03823209
View directory record Official record
Conditions
Human Immunodeficiency Virus
Interventions
Social Network, Brief HIV Prevention Counseling
Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
16 Years and older · Male only
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
2
States / cities
Cleveland, Ohio • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Microbicide Safety and Acceptability in Young Men

NCT01283360
View directory record Official record
Conditions
High Risk MSM, HIV Negative, 18-30 Years of Age
Interventions
HEC Placebo Gel, Tenofovir 1% Gel
Other · Drug
Lead sponsor
CONRAD
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
2
States / cities
Boston, Massachusetts • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Black Men Evolving Behavioral HIV Prevention Intervention for Black MSM

NCT01722838
View directory record Official record
Conditions
HIV CDC Category A1
Interventions
B-ME Intervention
Behavioral
Lead sponsor
Loyola University Chicago
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
438 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Mobile Intervention to Improve Uptake of PrEP for Southern Black MSM

NCT03308097
View directory record Official record
Conditions
Hiv
Interventions
PrEP Mobile Messaging Intervention, Enhanced Standard of Care
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Feb 20, 2021 · Synced Sep 12, 2026, 4:56 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Novel Internet-Based Interventions to Reduce Sexual Risk Among Men Who Have Sex With Men

NCT00649701
View directory record Official record
Conditions
HIV Infections
Interventions
Standard Text-Based Prevention Web Page, The Morning After, Talking About HIV, Both Videos
Behavioral
Lead sponsor
Public Health Solutions
Other
Eligibility
18 Years and older · Male only
Enrollment
3,097 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 19, 2008 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Enhancing Recruitment, Linkage to Care and Treatment for HIV-Infected MSM in the United States

NCT02663219
View directory record Official record
Conditions
HIV
Interventions
Intervention
Behavioral
Lead sponsor
HIV Prevention Trials Network
Network
Eligibility
16 Years and older · Male only
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Birmingham, Alabama • Atlanta, Georgia • Baltimore, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Entre Herman@s: Promoting Health Among Latino MSM

NCT05805306
View directory record Official record
Conditions
HIV Infections
Interventions
Entre Herman@s, Vaccines for Health
Behavioral
Lead sponsor
Charles Drew University of Medicine and Science
Other
Eligibility
18 Years to 39 Years
Enrollment
288 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Methylsulfonylmethane (MSM) on Cardiometabolic Health

NCT03716791
View directory record Official record
Conditions
Obesity
Interventions
methylsulfonylmethane, placebo
Dietary Supplement
Lead sponsor
Lindsey Miller
Other
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 12, 2026, 4:56 PM EDT
Completed Phase 4 Interventional Results available

Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM

NCT03608774
View directory record Official record
Conditions
Anal Chlamydia Infection
Interventions
Azithromycin, Doxycycline, Placebo
Drug · Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 99 Years · Male only
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Sep 12, 2026, 4:56 PM EDT