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ClinicalTrials.gov public records Last synced Oct 23, 2026, 3:09 AM EDT

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Showing 337–360 of 455 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Malaise Clear all
Completed Phase 2 Interventional Results available

Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease

NCT00590018
View directory record Official record
Conditions
Cardiac Output, Low
Interventions
Hydrocortisone, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
Up to 1 Month
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 26, 2016 · Synced Oct 23, 2026, 3:09 AM EDT
Withdrawn Phase 4 Interventional

High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy

NCT03846258
View directory record Official record
Conditions
Metabolic Acidosis, Acute Kidney Injury, Acute Kidney Failure
Interventions
Low bicarbonate solution (22 mmol/L), High Bicarbonate solution (32 mmol/L)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Not applicable Interventional Results available

Efficacy Study on Silver-coated ETT Cleaned With a Novel Device

NCT02120001
View directory record Official record
Conditions
Ventilator Associated Pneumonia, Critically Ill
Interventions
ETT cleaning maneuver
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 19, 2017 · Synced Oct 23, 2026, 3:09 AM EDT
Terminated Not applicable Interventional

The Role of the Pharmacist and Pharmacogenomics in the Care of Seriously Ill Patients

NCT04251520
View directory record Official record
Conditions
Palliative Medicine
Interventions
Pharmacogenomics testing, Pharmacist review
Diagnostic Test · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 5, 2022 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Phase 4 Interventional

Study of the Use of Coated Venous Catheters in the Critically Ill Child

NCT00202813
View directory record Official record
Conditions
Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter
Interventions
Cook Spectrum Pediatric Central Venous Catheter Anti-microbial Impregnated Polyurethane and Arrow Pediatric Central Venous Catheter
Device
Lead sponsor
Corewell Health West
Other
Eligibility
Up to 18 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Oct 23, 2026, 3:09 AM EDT
Terminated Phase 3 Interventional

Isavuconazole for the Prevention of COVID-19-associated Pulmonary Aspergillosis

NCT04707703
View directory record Official record
Conditions
Severe Acute Respiratory Syndrome Coronavirus 2, Aspergillosis Invasive
Interventions
Isavuconazonium Injection [Cresemba], Placebo
Drug
Lead sponsor
Jeffrey Jenks, MD, MPH
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
3
States / cities
Orange, California • Sacramento, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2022 · Synced Oct 23, 2026, 3:09 AM EDT
Recruiting Not applicable Interventional

VoiceLove: An App-Based COMMunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE)

NCT06923462
View directory record Official record
Conditions
Critical Illness, Intensive Care Medicine
Interventions
Communication Application
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 23, 2026, 3:09 AM EDT
Not listed Not applicable Interventional

Sleep Promotion in Critically Ill and Injured Patients Cared for in the Intensive Care Unit

NCT01082016
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Sleep Enhancement Program (SEP)
Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 55 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 20, 2010 · Synced Oct 23, 2026, 3:09 AM EDT
Completed No phase listed Observational

Decision Making in Serious Pediatric Illness

NCT01163136
View directory record Official record
Conditions
Parental Decision Making for Seriously Ill Children
Interventions
Not listed
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years and older
Enrollment
358 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 3, 2017 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Phase 1 Interventional

Effect of Stellate Ganglion Block on ME/CFS

NCT05664711
View directory record Official record
Conditions
Encephalomyelitis, Myalgic, Chronic Fatigue Syndrome, Chronic Fatigue Disorder, Chronic Fatigue and Immune Dysfunction Syndrome, Myalgic Encephalomyelitis, Postviral Fatigue Syndrome, Systemic Exertion Intolerance Disease, Infectious Mononucleosis-Like Syndrome, Chronic, Chronic Fatigue-Fibromyalgia Syndrome
Interventions
Bupivacaine Injection
Drug
Lead sponsor
Neuroversion, Inc.
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Phase 4 Interventional Results available

Intravenous Exenatide in Patients With Acute Brain Injury

NCT02058940
View directory record Official record
Conditions
Brain Injuries
Interventions
Exenatide
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Oct 23, 2026, 3:09 AM EDT
Completed No phase listed Observational

A Sample Collection Study to Validate the Astute Medical NephroCheck Test in Critically Ill Subjects at Risk for Acute Kidney Injury

NCT01573962
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Not listed
Lead sponsor
Astute Medical, Inc.
Industry
Eligibility
21 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
23
States / cities
Loma Linda, California • Los Angels, California • Washington D.C., District of Columbia + 18 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2014 · Synced Oct 23, 2026, 3:09 AM EDT
Not yet recruiting Not applicable Interventional

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

NCT07714200
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion, Varenicline, Mobile Contingency Management, Clinic-Based Smoking Cessation Counseling
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury

NCT03496545
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Subdural Hematoma, Traumatic Brain Injury, Ischemic Stroke, Fever, Intracerebral Hemorrhage
Interventions
Bromocriptine 5 MG, Acetaminophen 650 MG
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 100 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 24, 2021 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Transforming Psychotherapy for Chronically Ill Patients

NCT00520429
View directory record Official record
Conditions
Heart Failure, Congestive, Pulmonary Disease, Chronic Obstructive, Depression, Anxiety
Interventions
ACCES - Adjusting to Chronic Conditions with Education and Support
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2009 · Synced Oct 23, 2026, 3:09 AM EDT
Withdrawn No phase listed Observational

Effect of Cumulative Chloride Dose on Development of Acute Kidney Injury in Critically Ill Children

NCT02188602
View directory record Official record
Conditions
Acute Kidney Injury
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
1 Month to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2022 · Synced Oct 23, 2026, 3:09 AM EDT
Completed No phase listed Observational

Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19

NCT05336656
View directory record Official record
Conditions
COVID-19, ARDS, Withdrawal Syndrome, Iatrogenic Disease
Interventions
Not listed
Lead sponsor
Wilkes University
Other
Eligibility
18 Years to 90 Years
Enrollment
353 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Oct 23, 2026, 3:09 AM EDT
Withdrawn No phase listed Observational

Brief Delirium Assessments in Non-Intensive Care Unit (ICU) Patients

NCT01162369
View directory record Official record
Conditions
Delirium
Interventions
Not listed
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
65 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Phase 4 Interventional

Ceftaroline Pharmacokinetics in Continuous Renal Replacement Therapy

NCT04152694
View directory record Official record
Conditions
Infection During Renal Replacement Therapy, Critically Ill
Interventions
Ceftaroline levels in CRRT
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 18, 2021 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Not applicable Interventional

The DIVINE Study: DIetary Management of Glucose VarIability iN thE ICU

NCT02337556
View directory record Official record
Conditions
Critically Ill Mechanically Ventilated Subjects
Interventions
Peptamen Bariatric, Replete
Other
Lead sponsor
Société des Produits Nestlé (SPN)
Industry
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
6
States / cities
Atlanta, Georgia • Chicago, Illinois • Lexington, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2018 · Synced Oct 23, 2026, 3:09 AM EDT
Not listed Not applicable Interventional

A ProspectiveTrial Using Video Images in Advance Care Planning in Hospitalized Seriously Ill Patients With Advanced Cancer

NCT01527331
View directory record Official record
Conditions
Advanced Cancer
Interventions
video decision aid
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2020 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Phase 3 Interventional Results available

Convalescent Plasma Collection and Treatment in Pediatrics and Adults

NCT04376034
View directory record Official record
Conditions
COVID19, Coronavirus Infection, Coronavirus, Virus Diseases, RNA Virus Infections
Interventions
Convalescent Plasma
Biological
Lead sponsor
West Virginia University
Other
Eligibility
31 Days and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 23, 2026, 3:09 AM EDT
Not listed Not applicable Interventional

A Prospective Randomized Trial Using Video Images in Advance Care Planning in Seriously Ill Hospitalized Patients

NCT01325519
View directory record Official record
Conditions
Decision Making, Video Decision Aids
Interventions
video decision aid
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2020 · Synced Oct 23, 2026, 3:09 AM EDT
Completed Phase 3 Interventional

Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial

NCT03374800
View directory record Official record
Conditions
Gastrointestinal Hemorrhage (Clinically Important, Upper)
Interventions
Placebo (0.9% saline), Pantoprazole
Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
4,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 20, 2024 · Synced Oct 23, 2026, 3:09 AM EDT