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ClinicalTrials.gov public records Last synced Sep 2, 2026, 3:38 AM EDT

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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Malocclusion, Misaligned Teeth
Interventions
Clear Aligners with Dental Monitoring, Clear Aligners
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
12 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2029
U.S. locations
4
States / cities
Antioch, Illinois • Chicago, Illinois • Grayslake, Illinois + 1 more
Conditions
Malocclusion
Interventions
SureSmile® Clear Aligners
Device
Lead sponsor
Dentsply Sirona Implants and Consumables
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Fresno, California • Princeton Junction, New Jersey • Huntersville, North Carolina + 1 more
Conditions
Tooth Movement, Malocclusion
Interventions
AcceleDent, Vibrational Device
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Malocclusion
Interventions
Fixed Orthodontic Appliance Treatment, OrthoPulse™, Non-Functional OrthoPulse™
Other · Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
12 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Suwanee, Georgia
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Clear Aligner Attachment Design on Extrusion of Maxillary Lateral Incisors

NCT04968353
Conditions
Maxillary Lateral Incisor Malocclusion
Interventions
Incisally-beveled attachment, Gingivally-beveled attachment, Optimized attachment, Horizontal attachment
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
16 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Richmond, Virginia
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparison Between GUMMETAL and SS Orthodontic Wires in Space Closure

NCT04591080
Conditions
Malocclusion, Angle Class I
Interventions
GUMMETAL Orthodontic Wire, Stainless Steel (CrNi)
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
12 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Conditions
Malocclusions, Narrow Maxilla, Narrow Maxillary Arch, Crowding
Interventions
Removable Rapid Palatal Expander, Banded Palatal Expander
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
6 Years to 11 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Laguna Hills, California • Warner Robins, Georgia • Naperville, Illinois + 1 more
Active, not recruiting No phase listed Observational

Dental Malocclusion and Craniofacial Development in OI

NCT02934451
Conditions
Osteogenesis Imperfecta
Interventions
Not listed
Lead sponsor
Baylor College of Medicine
Other
Eligibility
10 Years to 100 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
2
States / cities
Los Angeles, California • Houston, Texas
Conditions
Mandibular Fractures
Interventions
MatrixWAVE MMF System
Procedure
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New York, New York
Not listed Not applicable Interventional

Orthodontic Archwire Comparison Trial

NCT02983084
Conditions
Malocclusion
Interventions
Orthodontic archwire
Device
Lead sponsor
Ormco Corporation
Industry
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Not listed No phase listed Observational Accepts healthy volunteers

EXD-959 Orthodontic Brackets and EXD-961 Related Instruments Trial

NCT03606551
Conditions
Malocclusion
Interventions
EXD-959 Bracket System
Device
Lead sponsor
3M
Industry
Eligibility
11 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
5
States / cities
Culver City, California • Wellington, Florida • Northfield, Minnesota + 2 more
Recruiting Not applicable Interventional Accepts healthy volunteers

IOA Preventing Occlusal Changes With MAD Use

NCT07103941
Conditions
Sleep Related Breathing Disorder, Snoring, Obstructive Sleep Apnea (OSA), Open Bite, Occlusal Changes, Tooth Migration, Posterior Open Bite
Interventions
AM Aligner, Exercise
Device · Behavioral
Lead sponsor
Isabel Moreno Hay
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Carriere Motion Appliance* Versus In-office Sectional Appliance

NCT05204654
Conditions
Angle Class 2 Malocclusion
Interventions
In-office fabricated appliance, Carriere Motion Appliance
Other · Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
12 Years to 17 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Conditions
Malocclusion
Interventions
interceptive orthodontic treatments
Procedure
Lead sponsor
University of Washington
Other
Eligibility
8 Years to 11 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Seattle, Washington
Completed Not applicable Interventional Accepts healthy volunteers Results available

Primer Aligner Study

NCT02550938
Conditions
Malocclusion
Interventions
Invisalign
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
13
States / cities
Anthem, Arizona • Napa, California • Oakland, California + 10 more
Conditions
Malocclusion, Angle Class I
Interventions
Surgically facilitated orthodontics therapy (SFOT) using allograft, Surgically facilitated orthodontics therapy (SFOT) using xenograft, Usual care
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Houston, Texas
Conditions
Malocclusion
Interventions
Micro-osteoperforation, Anesthestic, Chlorhexidine
Device · Drug · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Completed Not applicable Interventional Accepts healthy volunteers

Effect of VPro5 Therapy on Clear Aligner Therapy

NCT03240770
Conditions
Malocclusion
Interventions
VPro5 device, Deviation from Standard Tray Wear Time (14 Days)
Device · Other
Lead sponsor
Mani Alikhani
Industry
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
4
States / cities
Hoboken, New Jersey • Brooklyn, New York • San Antonio, Texas
Conditions
Dentofacial Abnormalities, Dentofacial Deformities, Dentofacial Anomalies, Including Malocclusion, Malocclusion, Malocclusion in Children, Dentofacial Disharmony, Skeletal Malocclusion, Skeletal Malformation, Speech Sound Disorder, Speech Disorders
Interventions
Orthognathic surgery and Orthodontics
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
15 Years to 40 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Recruiting No phase listed Observational Accepts healthy volunteers

Exploration of the Utility of Dental-dedicated MRI for Dentistry

NCT06948162
Conditions
Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment, Endodontic Lesions, PeriodontalConditions, Oral Surgery Conditions, Tooth Extractions, Local Anesthesia, Traumatic Dental Pain, TMJ, Orthodontics, Endodontic Histopathology, Periodontal Diseases
Interventions
dental-dedicated MRI (ddMRI)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Malocclusion
Interventions
AcceleDent Aura, Sham Device
Device
Lead sponsor
OrthoAccel Technologies Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Completed Not applicable Interventional Accepts healthy volunteers Results available

BRIUS Vs FFA Efficiency

NCT04347018
Conditions
Dental Malocclusion, Angle Class II, Angle Class I, Crowding, Tooth
Interventions
BRIUS
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
10 Years to 17 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of a "Flash-free" Adhesive Resin for Orthodontic Bracket Bonding

NCT02030002
Conditions
Malocclusion
Interventions
APC Flash-Free Adhesive Coated Appliance System, APC II Adhesive Coated Appliance System
Device
Lead sponsor
University of Minnesota
Other
Eligibility
10 Years to 60 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Malocclusion
Interventions
OrthoPulse™
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Suwanee, Georgia