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ClinicalTrials.gov public records Last synced Sep 11, 2026, 8:28 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Not listed Not applicable Interventional Accepts healthy volunteers

OrthoPulse 2.0 and 2.1 Feasibility Evaluation

NCT03683017
Conditions
Malocclusion
Interventions
OrthoPulse 2.0, OrthoPulse 2.1, Invisalign 3.5 Day Wear, Fixed Orthodontic Appliances (Braces)
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
6
States / cities
Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona + 3 more
Conditions
Osteogenesis Imperfecta
Interventions
Invisalign
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
12 Years to 40 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Los Angeles, California • Bethesda, Maryland
Completed Not applicable Interventional Accepts healthy volunteers

RCT Comparing Invisalign and Traditional Orthodontic Treatment

NCT04556448
Conditions
Malocclusion, Angle Class II
Interventions
Aligners, Clear braces
Other
Lead sponsor
Texas A&M University
Other
Eligibility
17 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Tooth Crowding
Interventions
Light Force (150g Niti Coil), Heavy Force (400 g Niti coil)
Device
Lead sponsor
UConn Health
Other
Eligibility
11 Years to 16 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Farmington, Connecticut
Conditions
Malocclusion
Interventions
Extraoral OrthoPulse® PBM, Fixed Orthodontic Appliance Treatment
Device · Other
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 40 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Birmingham, Alabama • Suwanee, Georgia
Conditions
Malocclusion
Interventions
OrthoAccel Device, Sham Device
Device
Lead sponsor
OrthoAccel Technologies Inc.
Industry
Eligibility
12 Years to 40 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Antonio, Texas
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparison Between GUMMETAL and SS Orthodontic Wires in Space Closure

NCT04591080
Conditions
Malocclusion, Angle Class I
Interventions
GUMMETAL Orthodontic Wire, Stainless Steel (CrNi)
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
12 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Conditions
Malocclusion
Interventions
OrthoPulse™
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Suwanee, Georgia
Conditions
Malocclusion
Interventions
SureSmile® Clear Aligners
Device
Lead sponsor
Dentsply Sirona Implants and Consumables
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Fresno, California • Princeton Junction, New Jersey • Huntersville, North Carolina + 1 more
Conditions
Malocclusion
Interventions
AcceleDent Aura, Accelerated Invisalign therapy
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Completed Not applicable Interventional Accepts healthy volunteers Results available

BRIUS Vs FFA Efficiency

NCT04347018
Conditions
Dental Malocclusion, Angle Class II, Angle Class I, Crowding, Tooth
Interventions
BRIUS
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
10 Years to 17 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Conditions
Malocclusion
Interventions
Bromelain
Dietary Supplement
Lead sponsor
Mohamed Bazina
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Not listed No phase listed Observational Accepts healthy volunteers

EXD-959 Orthodontic Brackets and EXD-961 Related Instruments Trial

NCT03606551
Conditions
Malocclusion
Interventions
EXD-959 Bracket System
Device
Lead sponsor
3M
Industry
Eligibility
11 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
5
States / cities
Culver City, California • Wellington, Florida • Northfield, Minnesota + 2 more
Conditions
Malocclusion
Interventions
Motion View, Conventional Orthodontic Treatment
Procedure
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
Up to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Malocclusion
Interventions
AcceleDent Aura, Sham Device
Device
Lead sponsor
OrthoAccel Technologies Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Recruiting No phase listed Observational Accepts healthy volunteers

Exploration of the Utility of Dental-dedicated MRI for Dentistry

NCT06948162
Conditions
Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment, Endodontic Lesions, PeriodontalConditions, Oral Surgery Conditions, Tooth Extractions, Local Anesthesia, Traumatic Dental Pain, TMJ, Orthodontics, Endodontic Histopathology, Periodontal Diseases
Interventions
dental-dedicated MRI (ddMRI)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Clear Aligner Trays to Straighten Teeth

NCT03141788
Conditions
Malocclusion
Interventions
Clear Aligner
Device
Lead sponsor
Solventum Orthodontics Corporation
Industry
Eligibility
14 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
9
States / cities
Denver, Colorado • Kennesaw, Georgia • Catonsville, Maryland + 5 more
Completed No phase listed Observational Accepts healthy volunteers

One Week Aligner Evaluation

NCT02603289
Conditions
Malocclusion
Interventions
Invisalign
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
Not listed
Enrollment
287 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
23
States / cities
Livermore, California • Napa, California • San Francisco, California + 20 more
Terminated No phase listed Observational Accepts healthy volunteers

Three-dimensional Assessment of Craniofacial Structures

NCT01210547
Conditions
Malocclusion
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
Not listed
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Mandibular Fractures
Interventions
MatrixWAVE MMF System
Procedure
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New York, New York
Conditions
Malocclusion, Angle Class I
Interventions
Surgically facilitated orthodontics therapy (SFOT) using allograft, Surgically facilitated orthodontics therapy (SFOT) using xenograft, Usual care
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Houston, Texas
Conditions
Malocclusion
Interventions
Micro-osteoperforation, Anesthestic, Chlorhexidine
Device · Drug · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Malocclusion
Interventions
Lower Anterior EXD-952 Self-ligating Brackets
Device
Lead sponsor
University of Minnesota
Other
Eligibility
10 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Obstructive Sleep Apnea, Malocclusion
Interventions
Homeoblock
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
The Bronx, New York