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ClinicalTrials.gov public records Last synced Oct 20, 2026, 3:46 AM EDT

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Showing 289–312 of 353 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Manipulation Clear all
Completed Not applicable Interventional

Short-Term Response of Thoracic Spine Manipulation With or Without Trigger Point Dry Needling for Mechanical Neck Pain

NCT02415660
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spinal manipulation, Trigger point dry needling, Cervical range of motion exercises, Posterior neck muscle activation exercise, Trigger point dry needling sham, Seirin J-type stainless steel needles, 0-2-0.3 x 40-50 mm
Procedure · Behavioral · Device
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Oct 20, 2026, 3:46 AM EDT
Terminated Not applicable Interventional

Reduction of Concussion Symptoms Through the Use of Osteopathic Manipulative Therapy

NCT04063618
View directory record Official record
Conditions
Concussion, Brain
Interventions
Osteopathic Manipulative Therapy, Standard of Care Concussion Treatment
Procedure
Lead sponsor
Matthew T. Mcelroy, DO
Other
Eligibility
Up to 24 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 31, 2023 · Synced Oct 20, 2026, 3:46 AM EDT
Recruiting Phase 2 Interventional

Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

NCT05800210
View directory record Official record
Conditions
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Juvenile Myelomonocytic Leukemia, Myelodysplastic Syndromes, Chronic Myeloid Leukemia, Lymphoma, Non-Hodgkin, Lymphoma, Hodgkin
Interventions
Miltenyi CliniMACS Prodigy ® system
Device
Lead sponsor
University of Florida
Other
Eligibility
6 Months to 39 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 20, 2026, 3:46 AM EDT
Enrolling by invitation No phase listed Observational

Influence of Flexion Distraction Manipulation on Measures of Performance and Postural Control

NCT06965920
View directory record Official record
Conditions
Spine Condition, Low Back Pain
Interventions
Not listed
Lead sponsor
Keiser University College of Chiropractic Medicine
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
West Palm Beach, Florida
Source: ClinicalTrials.gov public record
Updated May 18, 2025 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

OMT to Improve Feeding After Hypothermia

NCT03380013
View directory record Official record
Conditions
Neonatal Encephalopathy, Feeding; Difficult, Newborn
Interventions
Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
MaineHealth
Other
Eligibility
37 Weeks and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated May 31, 2019 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Motion Capture Analysis of Sacroiliac Joint Motion After Manipulation

NCT00620906
View directory record Official record
Conditions
Sacroiliac Joint Pain
Interventions
Manipulation
Procedure
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
20 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated May 3, 2013 · Synced Oct 20, 2026, 3:46 AM EDT
Completed No phase listed Observational

Infant s Examination and Manipulation of Objects

NCT00053469
View directory record Official record
Conditions
Healthy, Infant
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
Up to 2 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 20, 2026, 3:46 AM EDT
Not listed Not applicable Interventional

Effects of Osteopathic Manipulative Treatment (OMT) on Gait Biomechanics in Parkinson's Disease

NCT03616145
View directory record Official record
Conditions
Parkinson Disease
Interventions
Osteopathic Manipulative Treatment (OMT), Light Touch
Procedure · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 13, 2023 · Synced Oct 20, 2026, 3:46 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI

NCT03918473
View directory record Official record
Conditions
Ankle Sprains
Interventions
Mobilization with Movement, Thrust Mobilization
Other
Lead sponsor
Shenandoah University
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Results available

Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)

NCT01943435
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
NSAIDs; adjunctive analgesics; adjunctive anti-depressants, Lumbar epidural injection, Joint Mobilizations (spine, sacroiliac, hip), Individualized exercises: clinical setting, Group Exercise: community setting
Drug · Procedure · Other
Lead sponsor
Michael Schneider, DC, PhD
Other
Eligibility
60 Years and older
Enrollment
259 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 2, 2018 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Therapy Effects on Prolonged Post-COVID Olfactory Dysfunction

NCT05112887
View directory record Official record
Conditions
COVID-19 Lower Respiratory Infection, SARS-CoV2 Infection
Interventions
Osteopathic Manipulative Therapy
Other
Lead sponsor
Ohio University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Dublin, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 9, 2021 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional

Evaluating Hunger Manipulation During Feeding Intervention

NCT05053438
View directory record Official record
Conditions
Feeding Disorders, Feeding and Eating Disorders, Avoidant/Restrictive Food Intake Disorder
Interventions
Intensive Multidisciplinary Feeding Intervention (IMFI)-Standard of Care, Intensive Multidisciplinary Feeding Intervention (IMFI) standard of care + rapid tube weaning
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Months to 6 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 28, 2023 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preliminary Evaluation of an Osteopathic Manipulative Treatment (OMT) to Prevent Motion Sickness Symptoms

NCT05611814
View directory record Official record
Conditions
Motion Sickness
Interventions
Osteopathic Manipulative Treatment, Sham treatment
Other
Lead sponsor
United States Army Aeromedical Research Laboratory
Federal
Eligibility
19 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Rucker, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 10, 2022 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Phase 1Phase 2 Interventional Results available

The Mechanisms of Manual Therapy in the Treatment of Low Back Pain

NCT01168999
View directory record Official record
Conditions
Low Back Pain
Interventions
spinal manipulation, sham spinal manipulation, Enhanced sham spinal manipulation
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 28, 2015 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Results available

Chiropractic Manipulation and Medical Care for Low Back Pain

NCT01211613
View directory record Official record
Conditions
Low Back Pain
Interventions
Manual Manipulation, Mechanically-assisted manipulation, Standard Medical Care
Procedure · Device · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Oct 20, 2026, 3:46 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Satisfaction and Feasibility Evaluation of an Electronic Massager Compared to Massage Therapist-delivered Massage

NCT07042776
View directory record Official record
Conditions
Massage Therapy
Interventions
EMMA (Expert Manipulative Massage Automation), Therapist-delivered massage
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Results available

Veterans Response to Dosage in Chiropractic Therapy

NCT04087291
View directory record Official record
Conditions
Low Back Pain, Patient Acceptance of Health Care, Veterans Health
Interventions
Chiropractic Care
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years and older
Enrollment
766 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
4
States / cities
Los Angeles, California • West Haven, Connecticut • Iowa City, Iowa + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Phase 2 Interventional

Efficacy of Osteopathic Manipulation in Chronic Obstructive Pulmonary Disease

NCT00034112
View directory record Official record
Conditions
Emphysema
Interventions
osteopathic manipulative treatment
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
1
States / cities
Kirksville, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2006 · Synced Oct 20, 2026, 3:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Squat Jump Performance and Chiropractic Ankle Manipulation

NCT07641621
View directory record Official record
Conditions
Athletic Performance, Neuromuscular Adaptations, Lower Limb, Chiropractic Manipulation
Interventions
Manual Therapy Procedure: Chiropractic Ankle Manipulation
Other
Lead sponsor
Northeast College of Health Sciences
Other
Eligibility
18 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Seneca Falls, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of OMM on Anandamide Levels in Saliva

NCT02727023
View directory record Official record
Conditions
Anandamide, Endocannabinoids
Interventions
Osteopathic Manipulative Medicine
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Phase 2 Interventional

Spinal Manipulation for Treatment of Chronic Headaches

NCT00246350
View directory record Official record
Conditions
Headache Disorders
Interventions
massage, Spinal manipulation
Procedure
Lead sponsor
University of Western States
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 22, 2010 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of Osteopathic Manipulative Medicine on the Autonomic Nervous System

NCT02193373
View directory record Official record
Conditions
Osteopathic Manual Manipulation of Neurovascular Regulation
Interventions
Osteopathic Manual Medicine, Sham
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
20 Years to 50 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jul 5, 2019 · Synced Oct 20, 2026, 3:46 AM EDT
Completed Phase 2 Interventional

Manipulation, Exercise, and Self-Care for Neck Pain

NCT00269360
View directory record Official record
Conditions
Neck Pain
Interventions
Chiropractic + Supervised Rehabilitative Exercise, Supervised Rehabilitative Exercise, Self-care education
Procedure · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
18 Years to 65 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 20, 2007 · Synced Oct 20, 2026, 3:46 AM EDT
Withdrawn Not applicable Interventional

Reducing Arrhythmia in Dialysis by Adjusting the Rx Electrolytes/Ultrafiltration, Study B

NCT03519360
View directory record Official record
Conditions
End Stage Renal Disease
Interventions
UFR-restricted dialysis, UFR-unrestricted dialysis
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Oct 20, 2026, 3:46 AM EDT