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ClinicalTrials.gov public records Last synced Oct 20, 2026, 5:07 AM EDT

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Showing 337–353 of 353 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Manipulation Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Mobilization in Conjunction With Therapeutic Exercise in Participants With a History of Ankle Sprain

NCT02945943
View directory record Official record
Conditions
Functional Deficits, Manipulation, Rehabilitation
Interventions
High Velocity Low Amplitude mobilization, Exercise Protocol
Other
Lead sponsor
Shenandoah University
Other
Eligibility
16 Years to 35 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Winchester, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Manipulation, Exercise, and Self-Care for Low Back Pain

NCT00269347
View directory record Official record
Conditions
Low Back Pain
Interventions
Chiropractic Spinal Manipulation, Exercise, Self-care
Procedure · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2005
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 23, 2005 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Not applicable Interventional

PRoGReSS-PS: Patient Response to GRraded Sensory Stimulation: A Pilot Study

NCT01842737
View directory record Official record
Conditions
Low Back Pain
Interventions
Spinal treatment, Massage
Procedure
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Pregnancy-Related Low Back Pain and Complementary and Alternative Medicine (CAM) Treatment

NCT00937365
View directory record Official record
Conditions
Low Back Pain
Interventions
Exercise, Spinal Manipulation, Neuroemotional Technique (NET)
Behavioral · Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
20 Years to 49 Years · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 18, 2019 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Alterations in Bioelectric Activity at Acupuncture Points Following CV4 Cranial Manipulation

NCT05190731
View directory record Official record
Conditions
Autonomic Imbalance
Interventions
Osteopathic cranial manipulative medicine, Sham
Other
Lead sponsor
Jan T Hendryx
Other
Eligibility
18 Years to 78 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Erie, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 22, 2022 · Synced Oct 20, 2026, 5:07 AM EDT
Not listed Early Phase 1 Interventional

Clinical Assessment of Two Manipulative Protocols in Treatment of Hip Osteoarthritis

NCT00523172
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
manual or manipulative therapy, Manual / Manipulative Therapy, Supportive Care
Procedure
Lead sponsor
Cleveland Chiropractic College
Other
Eligibility
40 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 19, 2010 · Synced Oct 20, 2026, 5:07 AM EDT
Recruiting Not applicable Interventional

How Osteopathic Treatment Affects the Leg and Foot in People With Low Back Pain

NCT07193212
View directory record Official record
Conditions
Chronic Low Back Pain (CLBP)
Interventions
Osteopathic Manipulative Treatment
Other
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 20, 2026, 5:07 AM EDT
Recruiting Not applicable Interventional

Manipulation and Dry Needling in Patients With Cervicogenic Headache and WAD II

NCT06502951
View directory record Official record
Conditions
Cervicogenic Headache, Whiplash Injuries
Interventions
Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated May 11, 2025 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Chiropractic Manipulation on Spine-related Pain and Balance in Older Adults

NCT00497718
View directory record Official record
Conditions
Musculoskeletal Equilibrium, Back Pain
Interventions
Chiropractic Manipulation
Procedure
Lead sponsor
Cleveland Chiropractic College
Other
Eligibility
60 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 20, 2010 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Not applicable Interventional

Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain in Dentistry Students

NCT01962090
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic Spine Thrust in Seated Position, Thoracic Spine Thrust in Supine Position
Other
Lead sponsor
A.T. Still University of Health Sciences
Other
Eligibility
22 Years to 45 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Osteopathic Cranial Manipulative Medicine on Visual Function

NCT02728713
View directory record Official record
Conditions
Visual Function
Interventions
Cranial Manipulation, Sham/Placebo
Procedure
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 35 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Apr 5, 2016 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Phase 2 Interventional

Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy

NCT00011024
View directory record Official record
Conditions
Spastic Cerebral Palsy
Interventions
Self Hypnosis, Acupuncture, Osteopathic Manipulation
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
4 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2004
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 18, 2006 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Cranial Osteopathy on Visual Function

NCT00510562
View directory record Official record
Conditions
Visual Function
Interventions
Cranial osteopathic manipulation, Sham/Placebo
Procedure
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 35 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2002
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 20, 2026, 5:07 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

(MIST2)-Part2: AEs Following DC Care at DC Teaching Clinic: Electronic

NCT03412110
View directory record Official record
Conditions
Patient Safety, Manipulation, Spinal
Interventions
active surveillance: electronic platform
Other
Lead sponsor
Parker University
Other
Eligibility
Not listed
Enrollment
416 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Oct 20, 2026, 5:07 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Treatment RCT and Computational Modeling for Head Injuries in Mixed Martial Artists

NCT06851234
View directory record Official record
Conditions
Head Injury Trauma
Interventions
osteopathic manipulative medicine, The sham light touch will be performed by an investigator not trained in bodywork or a first--year osteopathic medical student.
Procedure
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years to 50 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Greenvale, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2025 · Synced Oct 20, 2026, 5:07 AM EDT
Completed Not applicable Interventional

The Effect of Combining Spinal Manipulation and Dry Needling in Individuals With Low Back Pain

NCT05802901
View directory record Official record
Conditions
Non-specific Low Back Pain
Interventions
Spinal manipulation, Dry needling, Spinal manipulation and dry needling
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Oct 20, 2026, 5:07 AM EDT
Withdrawn Not applicable Interventional

Asthma and Osteopathic Manipulative Technique

NCT07071194
View directory record Official record
Conditions
Asthma
Interventions
OMT, Light touch
Procedure · Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Mayfield Heights, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Oct 20, 2026, 5:07 AM EDT