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ClinicalTrials.gov public records Last synced Oct 19, 2026, 4:17 PM EDT

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Showing 73–96 of 353 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Manipulation Clear all
Terminated Phase 2 Interventional Results available

Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

NCT02946996
View directory record Official record
Conditions
Prostate Cancer
Interventions
Metformin, OPC
Drug · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older · Male only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Programmed Intermittent Epidural Bolus Time Interval and Injection Volume

NCT00417027
View directory record Official record
Conditions
Labor Pain
Interventions
Programmed Intermittent Epidural Bolus (PIEB)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 14, 2014 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neuroendocrine Changes in Cervical Spinal Manipulation and Mobilization Non-specific Mechanical Neck Pain

NCT04911608
View directory record Official record
Conditions
Neck Pain
Interventions
cervical spinal manipulation, cervical spinal mobilization
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2023 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional

The Effects of Thrust Joint Manipulation on the Resting and Contracting Thickness of Transversus Abdominis in Subjects With Low Back Pain

NCT02558855
View directory record Official record
Conditions
Low Back Pain
Interventions
Thrust Joint Manipulation of the Lumbar Spine, Non-thrust Joint Manipulation of the Lumbar Spine
Other
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 70 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
2
States / cities
Flagstaff, Arizona • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Apr 12, 2016 · Synced Oct 19, 2026, 4:17 PM EDT
Not listed Not applicable Interventional

The Effects of Thoracic Spine Manipulation in Individuals With Non-traumatic Cervical Pain

NCT01760590
View directory record Official record
Conditions
Neck Pain, Cervical Pain
Interventions
Manual Manipulation, Mobilization
Procedure
Lead sponsor
Keystone Rehabilitation Systems
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Bridgeville, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2013 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Phase 3 Interventional Results available

Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain

NCT03581123
View directory record Official record
Conditions
Acute Pain, Low Back Pain, Mechanical
Interventions
Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM, Standard Medical Care (SMC)
Behavioral · Other · Combination Product + 1 more
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
3
States / cities
Minneapolis, Minnesota • Pittsburgh, Pennsylvania • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Terminated Phase 4 Interventional

Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks

NCT00875862
View directory record Official record
Conditions
Adhesive Capsulitis, Post-operative Pain
Interventions
Interscalene catheter with Ropivicaine or normal saline
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Oct 19, 2026, 4:17 PM EDT
Withdrawn Not applicable Interventional

Anterior Cruciate Ligaments: Studying Updates in neuroCognition After Knee Manipulation

NCT07058467
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction Rehabilitation
Interventions
Joint Manipulation
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Terminated Not applicable Interventional

Effect of Spinal Manipulation on Vulvar Pain

NCT04016467
View directory record Official record
Conditions
Vulvodynia, Perineal Pain, Vulvar Pain
Interventions
Thoracic manipulation, Sham thoracic treatment
Other
Lead sponsor
University of Mary Hardin-Baylor
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Copperas Cove, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Balance Changes After Chiropractic Adjustments in Health Adults.

NCT03877367
View directory record Official record
Conditions
Postural Balance, Musculoskeletal Manipulation
Interventions
Upper extremity manipulation
Other
Lead sponsor
Parker University
Other
Eligibility
18 Years to 35 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 6, 2019 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Results available

Effect of Spinal Manipulation on Sensorimotor Functions in Back Pain Patients

NCT00830596
View directory record Official record
Conditions
Low Back Pain
Interventions
HVLA-SM, LVVA-SM, Sham Intervention
Other
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
21 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Oct 19, 2026, 4:17 PM EDT
Not listed Not applicable Interventional

Manual and Manipulative Therapy for Low Back Pain

NCT00632060
View directory record Official record
Conditions
Low Back Pain
Interventions
Manual / Manipulative Therapy (M/MT)
Procedure
Lead sponsor
Samueli Institute for Information Biology
Other
Eligibility
18 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Mar 10, 2008 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Manipulation Effects on Abdominal Muscles

NCT01745939
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Manipulation, Sham manipulation
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 5, 2014 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Phase 2Phase 3 Interventional

Validation of a Clinical Prediction Rule to Identify Patients With Shoulder Pain Likely to Benefit From Cervicothoracic Manipulation: A Randomized Clinical Trial

NCT01571674
View directory record Official record
Conditions
Shoulder Pain
Interventions
Manipulation + Exercise Group, Exercise Group
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
9
States / cities
Aurora, Colorado • Boulder, Colorado • Concord, New Hampshire + 5 more
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Oct 19, 2026, 4:17 PM EDT
Recruiting Not applicable Interventional

VCOM Pain Free Research Collaborative

NCT06533345
View directory record Official record
Conditions
Chronic Pain
Interventions
Behavior Change Coaching, Nutrition, Autonomic Recalibration, Dry Needling, Osteopathic Manipulative Treatment, Counseling Psychology, Multiple Treatments
Behavioral · Other · Procedure
Lead sponsor
Edward Via Virginia College of Osteopathic Medicine
Other
Eligibility
21 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Not yet recruiting Not applicable Interventional

Osteopathic Manipulative Treatment for Children With Chronic or Recurrent Otitis Media

NCT07639775
View directory record Official record
Conditions
Otitis Media, Otitis Media Effusion, Otitis Media Recurrent, Otitis Media With Effusion in Children, Otitis Media Chronic, Otitis Media in Children, Tympanostomy Tube Insertion, Osteopathic Manipulative Treatment (OMT)
Interventions
Experimental Osteopathic Manipulative Treatment (OMT) Protocol, Control Osteopathic Manipulative Treatment (OMT) Protocol
Other
Lead sponsor
Sarah Vidal
Other
Eligibility
6 Months to 6 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Lynchburg, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Study of Chitosan for Pharmacologic Manipulation of AGE Levels in Prostate Cancer Patients

NCT03712371
View directory record Official record
Conditions
Prostate Cancer
Interventions
Chitosan
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older · Male only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects

NCT00426244
View directory record Official record
Conditions
Low Back Pain, Pregnancy
Interventions
Osteopathic Manipulative Treatment, Placebo Ultrasound
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Oct 19, 2026, 4:17 PM EDT
Recruiting Not applicable Interventional

Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

NCT04142177
View directory record Official record
Conditions
Chronic Low Back Pain
Interventions
Pain EASE, Tailored exercise, Continued Care and Active Monitoring, Cognitive Behavioral Therapy (CBT), Spinal Manipulation Therapy (SMT), Yoga
Other · Procedure · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
2,529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
19
States / cities
Phoenix, Arizona • Loma Linda, California • Long Beach, California + 16 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Not yet recruiting Phase 4 Interventional

OMT for Adhesive Capsulitis

NCT07497737
View directory record Official record
Conditions
Adhesive Capsulitis of the Shoulder, Frozen Shoulder
Interventions
Intra-articular Injection, Osteopathic Manipulative Therapy (OMT)
Drug · Other
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Beachwood, Ohio • Westlake, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Medicine to Reduce Developmental Delays

NCT04652063
View directory record Official record
Conditions
Extreme Prematurity, Neurodevelopmental Abnormality
Interventions
Osteopathic Manipulative Medicine
Other
Lead sponsor
University of Rochester
Other
Eligibility
1 Day to 14 Weeks
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
2
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Impact of OMT on Physician Pain

NCT05488158
View directory record Official record
Conditions
Pain
Interventions
Osteopathic manipulation
Other
Lead sponsor
Fort Wayne Medical Education Program
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Oct 19, 2026, 4:17 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response

NCT00601341
View directory record Official record
Conditions
Knee Pain, Hip Pain, Ankle Pain, Lumbopelvic Pain
Interventions
lumbosacral joint manipulation, lumbar passive range of motion, No active intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 24, 2010 · Synced Oct 19, 2026, 4:17 PM EDT
Completed Not applicable Interventional

Spinal Manipulation and Dry Needling Versus Conventional Physical Therapy in Patients With Sacroiliac Dysfunction

NCT02373644
View directory record Official record
Conditions
Sacroiliac Joint Dysfunction
Interventions
HVLA Thrust Manipulation and DN, Conventional Physical Therapy
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Oct 19, 2026, 4:17 PM EDT