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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Marijuana Abuse and Dependence Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper

NCT00374127
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Marijuana blunt, marijuana cigarette
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep

NCT00893269
View directory record Official record
Conditions
Marijuana Dependence
Interventions
eszopiclone, Placebo, ramelteon, zolpidem
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 4, 2013 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 4 Interventional Results available

Clozapine for Cannabis Use in Schizophrenia

NCT01639872
View directory record Official record
Conditions
Schizophrenia, Cannabis Abuse, Cannabis Dependence, Dual Diagnosis
Interventions
Clozapine, Risperidone
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years to 55 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
9
States / cities
Garden Grove, California • Oakland, California • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sex Differences in Attentional Bias in Marijuana-dependent Individuals

NCT01179425
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Cognitive stressor
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 13, 2011 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional Results available

Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence

NCT01292642
View directory record Official record
Conditions
Cannabis Dependence, Nicotine Dependence
Interventions
Cognitive Behavioral Therapy, Nicotine Replacement Therapy
Behavioral · Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 13, 2013 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Not applicable Interventional

Treatment for Teens With Alcohol Abuse and Depression

NCT02227589
View directory record Official record
Conditions
AOD Use, Abuse, and Dependence, Depression
Interventions
MET/CBT-12, CBT-D, D-TAU
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
13 Years to 263 Months
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Farmington, Connecticut • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Ph1 Marinol Interaction Study - Part 2 - 1

NCT00490269
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Placebo, Dronabinol
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

THC Crossover Study

NCT04429568
View directory record Official record
Conditions
THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified, Cigarette Smoking, Tobacco Use, Nicotine Dependence, Nicotine Withdrawal, Cardiovascular Risk Factor
Interventions
Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional Results available

Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence

NCT02210195
View directory record Official record
Conditions
Cannabis Dependence, Alcohol Dependence, Cannabis Use Disorder, Alcohol Use Disorder
Interventions
aprepitant, Placebo, Manual-guided behavioral counseling
Drug · Behavioral
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2017 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional Results available

Effectiveness Study of Dronabinol and BRENDA for the Treatment of Cannabis Withdrawal

NCT00480441
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Dronabinol, BRENDA therapy, Placebo
Drug · Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 55 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 28, 2019 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effect of Lofexidine and Oral THC on Marijuana Withdrawal and Relapse

NCT00373503
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Lofexidine, dronabinol, Marijuana
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 4, 2013 · Synced Jun 25, 2026, 1:12 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Ph1 Marinol Interaction Study - Part 1 - 1

NCT00438139
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Dronabinol
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain

NCT04827992
View directory record Official record
Conditions
Opioid Use, Pain, Marijuana Use
Interventions
Cannabis, Prescription Opioid Taper Support (POTS)
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
Portland, Maine • Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults

NCT00656487
View directory record Official record
Conditions
Cannabis Dependence, Cannabis Withdrawal
Interventions
rimonabant, placebo
Drug
Lead sponsor
The Scripps Research Institute
Other
Eligibility
21 Years to 30 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 18, 2017 · Synced Jun 25, 2026, 1:12 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Young Adult Tobacco/Nicotine and Cannabis Co-use

NCT06239350
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence
Interventions
Counseling, Contingency management, Text-based support
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 25 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effect of Baclofen on Marijuana Withdrawal and Relapse

NCT00373295
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Baclofen, Marijuana, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional

Effectiveness of Buspirone and Motivational Enhancement Therapy for the Treatment of Marijuana Dependence - 1

NCT00149617
View directory record Official record
Conditions
Marijuana Abuse, Mood Disorders
Interventions
Buspirone
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 8, 2015 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional Results available

Atomoxetine Treatment for ADHD and Marijuana Dependence

NCT00360269
View directory record Official record
Conditions
Marijuana Abuse, Attention Deficit Disorder With Hyperactivity
Interventions
Atomoxetine, Motivational enhancement therapy, Placebo
Drug · Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 29, 2014 · Synced Jun 25, 2026, 1:12 PM EDT
Completed No phase listed Observational

Quiting Marijuana Use: Self-report Study of Quitting Straegies and Withdrawal Symptoms

NCT01603992
View directory record Official record
Conditions
Cannabis Abuse, Cannabis Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
822 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
3
States / cities
Baltimore, Maryland • Catonsville, Maryland • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Jun 25, 2026, 1:12 PM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream

NCT06334016
View directory record Official record
Conditions
Cannabis Dependence
Interventions
Biospecimen Collection, Cannabis sativa Extract, Nicotine, Placebo Administration, Questionnaire Administration
Procedure · Drug · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional

Effectiveness of Nefazodone and Bupropion in Treating Marijuana Dependent Individuals

NCT00249509
View directory record Official record
Conditions
Marijuana Abuse
Interventions
Nefazodone, Bupropion
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2004
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Hormones and Reduction in Co-users of Marijuana and Nicotine

NCT02579421
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Progesterone, placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 25, 2020 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 2 Interventional Results available

Pregnenolone and Marijuana Dependence

NCT02439814
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Pregnenolone, Placebo
Drug · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2018 · Synced Jun 25, 2026, 1:12 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Medications Development for the Treatment of Cannabis Related Disorders

NCT01204723
View directory record Official record
Conditions
Nicotine Withdrawal, Marijuana Dependence, Cannabis Dependence, Nicotine Dependence, Cannabis Abuse
Interventions
Placebo Aprepitant, Active Aprepitant
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 45 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
2
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 31, 2012 · Synced Jun 25, 2026, 1:12 PM EDT