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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Marijuana Impairment Clear all
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance

NCT06351540
View directory record Official record
Conditions
Cannabis Use, Impaired Driving, Cognitive Impairment
Interventions
Cannabis
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Differences in Cannabis Impairment and Its Measurement Due to Route of Administration

NCT03122691
View directory record Official record
Conditions
Behavioral Pharmacology of Cannabis
Interventions
cannabis
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 45 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Delta-8-THC vs. Delta-9-THC on Simulated Driving Performance

NCT06218550
View directory record Official record
Conditions
Cannabis
Interventions
Delta-9-THC, Delta-8-THC, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Neuroscience of Marijuana Impaired Driving

NCT02757313
View directory record Official record
Conditions
Marijuana Impairment
Interventions
Low dose THC marijuana, High dose THC marijuana, Placebo marijuana
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 40 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Developing a Mobile Method to Measure THC-induced Impairment

NCT03804840
View directory record Official record
Conditions
Measuring THC-induced Cognitive Impairment Using a Mobile Application
Interventions
Dronabinol, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 35 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 21, 2026, 9:22 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Detection of Cannabis Impairment With ISBRG's SpotLight-THC

NCT05276232
View directory record Official record
Conditions
Cannabis
Interventions
Cannabis(THC) inhaled
Drug
Lead sponsor
ISBRG Corp
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Alcohol and Cannabis Concentrates Co-Administration

NCT05999344
View directory record Official record
Conditions
Alcohol Use Disorder, Cannabis Use
Interventions
commercially available cannabis administered prior to commercially available alcohol, commercially available alcohol administered prior to commercially available cannabis
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 65 Years
Enrollment
146 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jul 21, 2026, 9:22 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Eye Movement Tracking to Detect Impairment Due to Acute Cannabis Intoxication

NCT04799093
View directory record Official record
Conditions
Impairment, Cannabis Intoxication
Interventions
EyeBOX
Diagnostic Test
Lead sponsor
Oculogica, Inc.
Industry
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Westport, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 12, 2021 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Examine the Feasibility of a Standardized Field Test for Marijuana Impairment: Laboratory Evaluations

NCT03191084
View directory record Official record
Conditions
Marijuana Impairment
Interventions
Low Dose THC Marijuana, High Dose THC Marijuana, Placebo Marijuana
Drug
Lead sponsor
Yale University
Other
Eligibility
20 Years to 40 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Assessment of the Single Dose Pharmacokinetics and Tolerability of Sativex in Patients With Impaired Hepatic Function and Healthy Patients

NCT01887301
View directory record Official record
Conditions
Hepatic Impairment
Interventions
Sativex
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Anaheim, California • Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 19, 2022 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Validation of the Drug Impaired Driving Scenario (DIDS) on the CRCDS-miniSim

NCT04970342
View directory record Official record
Conditions
Driving Behavior, Driving Under the Influence
Interventions
Placebo (Lactose) Capsule, 0.75 mg Alprazolam Capsule, Cannabis (6.18% THC / <0.025% CBD), Cannabis (0%/ THC / 0% CBD)
Drug
Lead sponsor
Timothy L. Brown
Other
Eligibility
19 Years to 45 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Impact of Oral Cannabis Administration and Co-Administration of Alcohol on Impairment

NCT04931095
View directory record Official record
Conditions
Cannabis Intoxication, Alcohol Intoxication
Interventions
Cannabis, Alcohol
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jul 21, 2026, 9:22 PM EDT
Recruiting Phase 2 Interventional

CBD for Individuals at Risk for Alzheimer's Disease

NCT05822362
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Cannabidiol, Placebo
Drug · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
55 Years to 85 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

The Impact and Detection of Driving Impairments Associated With Acute Cannabis Smoking

NCT02849587
View directory record Official record
Conditions
Cannabis Intoxication
Interventions
Cannabis
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 55 Years
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 3, 2022 · Synced Jul 21, 2026, 9:22 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults

NCT06077292
View directory record Official record
Conditions
Cannabis Use, THC, Marijuana Use, Cognitive Impairment, THC Vaping
Interventions
15% THC Potency Reduction, 35% THC Potency Reduction
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 25 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 9:22 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Evaluation of an Eye Tracking Sensor to Detect Cannabis Impairment

NCT03994926
View directory record Official record
Conditions
Cannabis Intoxication
Interventions
Virtual Reality Eye Tracking after smoking Cannabis - HTC Vive Pro-Eye, Cannabis cigarette - 4.0% THC
Device · Drug
Lead sponsor
Battelle Memorial Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Jul 21, 2026, 9:22 PM EDT
Recruiting Not applicable Interventional

Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)

NCT06736444
View directory record Official record
Conditions
Insomnia, Alcohol Use, Marijuana Use
Interventions
Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS), Attention Control
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 29 Years
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jul 21, 2026, 9:22 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Neuroscience of Alcohol and Marijuana Impaired Driving

NCT03431987
View directory record Official record
Conditions
Marijuana Usage, Alcohol Drinking
Interventions
One day with a dose of placebo cannabis paired with alcohol, One day with a dose of active THC cannabis paired with alcohol
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
21 Years to 40 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cannabis Impairment Detection Application (CIDA)

NCT04230460
View directory record Official record
Conditions
Driving Under the Influence, Marijuana Intoxication, Alcohol Intoxication
Interventions
Cannabis (THC) (Inhaled) Placebo, Cannabis (High% THC) (Inhaled), Cannabis (Very High% THC) (Inhaled), Alcohol (oral)
Drug
Lead sponsor
Advanced Brain Monitoring, Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 11, 2021 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Examine the Feasibility of a Standardized Field Test for Marijuana and Alcohol Impairment: Laboratory Evaluations

NCT04856566
View directory record Official record
Conditions
Marijuana Impairment, Alcohol Impairment
Interventions
Low Marijuana, Hash, THC, or Grass, High Marijuana, Hash, THC, or Grass, Placebo, 0.05 BAC Alcohol, 0.08 BAC Alcohol
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 40 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

High Confusion: Cannabis & Driving

NCT06236815
View directory record Official record
Conditions
Impairment, Cognitive, Impairment of Attention, Impairment, Psychomotor
Interventions
Delta-9-THC, Delta-8-THC, Placebo
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 49 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Jul 21, 2026, 9:22 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment

NCT06293040
View directory record Official record
Conditions
Cannabis Intoxication, Alcohol Intoxication
Interventions
Cannabis, Alcohol, Placebo Cannabis, Placebo Alcohol
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jul 21, 2026, 9:22 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of Smoked THC and CBD in Men and Women

NCT05037487
View directory record Official record
Conditions
Drug Abuse, Intoxication by Drug, Impairment
Interventions
Placebo Cannabis, 20 mg CBD Cannabis, 20 mg CBD + 20 mg THC Cannabis, 20 mg THC Cannabis
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 55 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Jul 21, 2026, 9:22 PM EDT