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Showing 1–24 of 143 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Maternal Depression Clear all
Completed No phase listed Observational

Optimizing Medication Management for Mothers With Depression

NCT02519790
View directory record Official record
Conditions
Depression, Pregnancy
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
4
States / cities
Chicago, Illinois • Pittsburgh, Pennsylvania • Galveston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 16, 2021 · Synced Jul 21, 2026, 9:39 AM EDT
Enrolling by invitation Not applicable Interventional

The Social Determinants of Health Screening and Referral Project

NCT06582147
View directory record Official record
Conditions
Preterm Birth
Interventions
Implementation of social determinants of health screening and referral
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older · Female only
Enrollment
882 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
7
States / cities
Denver, Colorado • Jacksonville, Florida • Detroit, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 21, 2026, 9:39 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Maternal Well-Being Study

NCT05484999
View directory record Official record
Conditions
Postpartum Depression, Postpartum Anxiety, Weight Retention, Postpartum, Nutritional and Metabolic Diseases
Interventions
Meals, Meals + Social Support, Control
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years and older · Female only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Amarillo, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2024 · Synced Jul 21, 2026, 9:39 AM EDT
Recruiting Not applicable Interventional

Maternal Stress on Human Milk and Infant Outcomes

NCT04821544
View directory record Official record
Conditions
Postpartum Depression, Preterm Labor
Interventions
Mindfulness-based intervention (with a focus on self-compassion; MBSC), Vitamin D
Behavioral · Dietary Supplement
Lead sponsor
University of Idaho
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Coeur d'Alene, Idaho
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional

Psychotherapy for Depressed Mothers of Psychiatrically Ill Children

NCT00919594
View directory record Official record
Conditions
Depression
Interventions
Interpersonal Psychotherapy for Mothers (IPT-MOMS), Brief Supportive Psychotherapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
7 Years to 65 Years
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 18, 2017 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional Results available

The Momba Mobile Application-based Community

NCT01816945
View directory record Official record
Conditions
Mental Health Wellness 1
Interventions
MOMBA web-based application
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 17, 2021 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional Results available

New Haven MOMS Partnership

NCT01665872
View directory record Official record
Conditions
Depression, Stress
Interventions
Cognitive-Behavioral Group Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
16 Years and older · Female only
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 9, 2020 · Synced Jul 21, 2026, 9:39 AM EDT
Completed No phase listed Observational

The Effect of Magnesium on Maternal Mood, Cognitive Function, and Birth Experience

NCT02454322
View directory record Official record
Conditions
Depression, Postpartum
Interventions
Magnesium Sulfate
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 4, 2022 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional

Integrated Parent Training for Treating Depression in Mothers of Children With Attention Deficit Hyperactivity Disorder

NCT00316290
View directory record Official record
Conditions
Depression, Attention Deficit Disorder With Hyperactivity
Interventions
Integrated Parent Training, Behavioral Parent Training
Behavioral
Lead sponsor
University of Maryland, College Park
Other
Eligibility
6 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Doula Support for Young Mothers: A Randomized Trial

NCT01925664
View directory record Official record
Conditions
Parenting, Breastfeeding, Depression, Postpartum
Interventions
Doula
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
14 Years to 21 Years · Female only
Enrollment
248 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 4, 2013 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional

Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk Mechanisms

NCT03011801
View directory record Official record
Conditions
Depression
Interventions
Interpersonal Therapy, Enhanced usual care
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years and older · Female only
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
2
States / cities
Denver, Colorado • Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Jul 21, 2026, 9:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of Exposure to Stress, Postpartum Mood, Adverse Life Events, and Hormonal Function Among Latinas (SEPAH Latina)

NCT01912833
View directory record Official record
Conditions
Postpartum Depression
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 7, 2014 · Synced Jul 21, 2026, 9:39 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Pregnancy-Specific Anxiety on Placental Inflammatory and Oxidative Stress Response and Birth Outcomes

NCT04993742
View directory record Official record
Conditions
Placental Dysfunction, Prenatal Stress
Interventions
MOMS Intervention
Behavioral
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional

Treatment of Maternal Depression in Home Visitation: Mother and Child Impacts

NCT01212783
View directory record Official record
Conditions
Depressive Disorder in Mothers
Interventions
In-Home Cognitive Behavioral Therapy, Present-Centered Therapy
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional

Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study)

NCT00951717
View directory record Official record
Conditions
Depression, Postpartum, Depression
Interventions
Behavioral education intervention
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Enrollment
590 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 21, 2011 · Synced Jul 21, 2026, 9:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression

NCT06835855
View directory record Official record
Conditions
Depression - Major Depressive Disorder
Interventions
Passive Viewing Task, Interaction Task
Other
Lead sponsor
Binghamton University
Other
Eligibility
6 Months and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Binghamton, New York
Source: ClinicalTrials.gov public record
Updated Feb 19, 2025 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Meditation for NICU Moms

NCT03574766
View directory record Official record
Conditions
Breast Feeding, Premature Birth, Stress, Depression, Postpartum, Anxiety, Self Efficacy, Behavior, Maternal, Insufficient Lactation
Interventions
Meditation
Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Richmond Heights, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Jul 21, 2026, 9:39 AM EDT
Not yet recruiting Not applicable Interventional

Pilot Feasibility Study With Doulas

NCT07614789
View directory record Official record
Conditions
Post Partum, Maternal Depression, Maternal Depression and Parent Practices, Postpartum
Interventions
YouMatter
Behavioral
Lead sponsor
Duke University
Other
Eligibility
Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Phase 2 Interventional Results available

Inhaled Oxytocin and HPA Axis Reactivity

NCT03593473
View directory record Official record
Conditions
Depression, Postpartum, Anxiety Disorders, Stress, Psychological
Interventions
Intranasal Oxytocin, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional

Mother-Infant Intervention for Postpartum Depression and Associated Mother-Infant Relationship Dysfunction

NCT02057627
View directory record Official record
Conditions
Postpartum Depression
Interventions
Perinatal Dyadic Psychotherapy, Placebo Comparator
Behavioral
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
Female only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 19, 2016 · Synced Jul 21, 2026, 9:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Optimizing Clinical Screening and Management of Maternal Mental Health: Predicting Women at Risk for Perinatal Depression

NCT03144752
View directory record Official record
Conditions
Depression
Interventions
Not listed
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 44 Years · Female only
Enrollment
298 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2019 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional

MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence

NCT05106361
View directory record Official record
Conditions
Intimate Partner Violence, Depression, Post Traumatic Stress Disorder
Interventions
MOSAIC Plus, MOSAIC
Behavioral
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jul 21, 2026, 9:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Parent Encouragement And Coaching of Happiness in Youth

NCT06725160
View directory record Official record
Conditions
Depression, Parent-Child Relations
Interventions
Parent Coaching, Active Control
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
4 Years to 99 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Jul 21, 2026, 9:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Madres Para la Salud (Mothers for Health)

NCT01908959
View directory record Official record
Conditions
Overweight and Obesity, Depression, Postpartum, Mother (Person)
Interventions
Madres para la Salud
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
177 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 25, 2013 · Synced Jul 21, 2026, 9:39 AM EDT