Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Jul 22, 2026, 12:02 PM EDT

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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Conditions
Opioid Use Disorder, Maternal Drugs Affecting Fetus, Postpartum Mood Disturbance, Sleep Disorder, Neonatal Opioid Withdrawal
Interventions
Night Respite Care
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Mattapan, Massachusetts • Somerville, Massachusetts
Conditions
Alcohol-Related Disorders, Substance-Related Disorders, Mental Health, Reproductive Health, Sexual Health, Sexually Transmitted Diseases, Contraception, Maternal Health, Pregnancy, Women's Health
Interventions
Screening, Brief Intervention, and Referral to Treatment (SBIRT)
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Boston, Massachusetts • Marlborough, Massachusetts • Springfield, Massachusetts + 1 more
Recruiting No phase listed Observational Accepts healthy volunteers

Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

NCT03923374
Conditions
Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence
Interventions
Subutex / Buprenorphine, Fetal & Neonatal MRI, DNA/Genetic/Pharmacokenetic Blood Draws
Drug · Diagnostic Test
Lead sponsor
Senthil Sadhasivam
Other
Eligibility
18 Years and older · Female only
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Substance Use Disorders
Interventions
Motivational Interviewing (MI) and Acceptance and Commitment Therapy (ACT), Conventional Care
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Houston, Texas
Conditions
Nicotine Dependence
Interventions
Behavioral Counseling, Self-help control
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Substance Use Disorders, Pregnancy
Interventions
2 dimensional vs. 3 dimensional ultrasound
Other
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Honolulu, Hawaii
Conditions
Substance Use Treatment, Perinatal Substance Use, Parenting
Interventions
Proud of Baby and Me
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Little Rock, Arkansas
Conditions
Pregnancy Related, Substance Use, Mental Health Issue
Interventions
NEXUS intervention, Standardized Non-Medical fetal ultrasound
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 45 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving Future Thinking Among Mothers to Reduce Harsh Parenting and Improve Child Outcomes

NCT05229146
Conditions
Behavioral Health
Interventions
Episodic Future Thinking
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Flint, Michigan
Conditions
Opioid Use Disorder
Interventions
Group well child care
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Completed No phase listed Observational Accepts healthy volunteers

Maternal Brain Imaging in Opioid Use Disorder

NCT06008990
Conditions
Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related, Narcotic-Related Disorders, Buprenorphine Dependence
Interventions
Buprenorphine, Maternal Brain MRI, Blood Samples, Questionnaires
Drug · Diagnostic Test · Other + 1 more
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Improving Maternal Mental Health & SUD Screening and Treatment

NCT05764213
Conditions
Mental Health Issue, Substance Use Disorders, Postpartum Depression, Postpartum Anxiety
Interventions
Listening to Women & Pregnant and Postpartum People
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10,470 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Completed Not applicable Interventional Accepts healthy volunteers

Fetal Alcohol Damage Prevention Study

NCT00696085
Conditions
Fetal Alcohol Syndrome, Substance Abuse
Interventions
Brief motivational intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
612 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Substance Use Disorders, Children of Mothers With Substance Use Disorders
Interventions
THRIVE
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
3 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Child Behavior, Parent-Child Relations, Substance Use, Substance Abuse
Interventions
Filming Interactions to Nurture Development, The Healthy Toddler Program
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Up to 50 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Eugene, Oregon
Conditions
Cannabis Use Disorder, Pregnancy Related
Interventions
Maternal-fetal monitoring, NICU Network Neurobehavioral Scale
Device · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 44 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of EBT With Young, Substance Abusing Homeless Mothers

NCT02577666
Conditions
Substance Use
Interventions
Ecologically Based Therapy, Housing Only, Treatment as Usual
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 24 Years · Female only
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Conditions
Maternal Substance Use, Child Abuse and Neglect
Interventions
Mentalizing Therapy for Substance Using Mothers, Standard Parent Education for Substance Using Mothers
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Conditions
Substance Use Disorders, Pregnancy Related, Alcohol Use Disorder (AUD), Alcohol Use Complicating Pregnancy, First Trimester, Alcohol Use Complicating Pregnancy, Second Trimester, Alcohol Use Complicating Pregnancy, Third Trimester, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Alcohol Use Complicating Pregnancy, Childbirth, and the Puerperium, Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, Drug Use Disorders, Drug Use Complicating Pregnancy, First Trimester, Drug Use Complicating Pregnancy, Second Trimester, Drug Use Complicating Pregnancy, Third Trimester, Drug Use Complicating Pregnancy, Unspecified Trimester, Drug Use Complicating Pregnancy, Childbirth, and the Puerperium, Maternal Drugs Affecting Fetus
Interventions
Parent-Child Assistance Program
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Oklahoma City, Oklahoma • Tulsa, Oklahoma
Conditions
Substance Use Disorders, Parent-Child Relations, Parent Child Abuse
Interventions
MIO-CPP, MIO-CPP-CRS
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Female only
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions
Buprenorphine Injection, Buprenorphine Sublingual Product
Drug
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
12
States / cities
Jacksonville, Florida • Boston, Massachusetts • Albuquerque, New Mexico + 8 more
Conditions
Substance-Related Disorders
Interventions
BRIGHT, STAR/TAU+
Behavioral · Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Adverse Childhood Experiences
Interventions
Not listed
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Camden, New Jersey
Conditions
Opioid-use Disorder, Neonatal Abstinence Syndrome, Pregnancy, High Risk, Alcohol Use Disorder
Interventions
Pharmacokinetic analysis, Safety and Efficacy, Genetic and epigenetic analysis, Breast milk analysis
Other · Genetic
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Boston, Massachusetts • Carrboro, North Carolina