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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Maternal Substance Use Clear all
Completed No phase listed Observational

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study

NCT03911466
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions
Buprenorphine Injection, Buprenorphine Sublingual Product
Drug
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
12
States / cities
Jacksonville, Florida • Boston, Massachusetts • Albuquerque, New Mexico + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Recruiting No phase listed Observational

Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy

NCT05942313
View directory record Official record
Conditions
Opioid Use Disorder, Pregnancy Related
Interventions
Buprenorphine/ Methadone exposure
Drug
Lead sponsor
Ilana Hull
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Not listed Not applicable Interventional

Study of Ultrasound To Increase Parental Bonding in Women With Substance Use Disorders

NCT02158429
View directory record Official record
Conditions
Substance Use Disorders, Pregnancy
Interventions
2 dimensional vs. 3 dimensional ultrasound
Other
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Not applicable Interventional

Child Healthcare at MATER - Pediatric Study

NCT05488379
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Group well child care
Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Not applicable Interventional

Counseling to Reduce Children's SHS Exposure: A Trial With Maternal Smokers

NCT02117947
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Behavioral Counseling, Self-help control
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2017 · Synced Sep 6, 2026, 9:08 AM EDT
Completed No phase listed Observational

Maternal Opioid Treatment: Human Experimental Research - Data Yield Appropriate Decisions

NCT04049799
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Withdrawal, Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal Syndrome
Interventions
Medically-supervised withdrawal, Opioid agonist treatment, Comprehensive clinical care
Other · Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
4
States / cities
Asheville, North Carolina • Chapel Hill, North Carolina • Burlington, Vermont + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Sep 6, 2026, 9:08 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Improving Maternal Mental Health & SUD Screening and Treatment

NCT05764213
View directory record Official record
Conditions
Mental Health Issue, Substance Use Disorders, Postpartum Depression, Postpartum Anxiety
Interventions
Listening to Women & Pregnant and Postpartum People
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10,470 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Recruiting Not applicable Interventional

Postpartum Intervention for Mothers With Opioid Use Disorders (R33)

NCT07632053
View directory record Official record
Conditions
Opioid Use Disorder, Parent-Child Relations
Interventions
Mom Power
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Ann Arbor, Michigan • Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Not listed Not applicable Interventional

A Scaleable Video Coaching Intervention for Opioid-using Mothers

NCT04749771
View directory record Official record
Conditions
Child Behavior, Parent-Child Relations, Substance Use, Substance Abuse
Interventions
Filming Interactions to Nurture Development, The Healthy Toddler Program
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
Up to 50 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 28, 2023 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology

NCT02872467
View directory record Official record
Conditions
Substance Abuse Problem, Pregnancy
Interventions
Syntocinon treatment, Placebo
Drug · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 42 Years · Female only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 17, 2023 · Synced Sep 6, 2026, 9:08 AM EDT
Completed No phase listed Observational

Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study

NCT03911739
View directory record Official record
Conditions
Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse, Drug Abuse, Neonatal Abstinence Syndrome, Neonatal Opiate Withdrawal Syndrome, Drug Abuse in Pregnancy
Interventions
Buprenorphine Injection, Buprenorphine Sublingual Product
Drug
Lead sponsor
T. John Winhusen, PhD
Other
Eligibility
Not listed
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
10
States / cities
Jacksonville, Florida • Boston, Massachusetts • Portland, Oregon + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Recruiting Not applicable Interventional

Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT

NCT06969261
View directory record Official record
Conditions
Perinatal Opioid Use Disorder, Opioid Use Disorder
Interventions
Penny COPILOT
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fetal Alcohol Damage Prevention Study

NCT00696085
View directory record Official record
Conditions
Fetal Alcohol Syndrome, Substance Abuse
Interventions
Brief motivational intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
612 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2008 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Not applicable Interventional

Night Respite for Postpartum Mothers With SUD

NCT05746507
View directory record Official record
Conditions
Opioid Use Disorder, Maternal Drugs Affecting Fetus, Postpartum Mood Disturbance, Sleep Disorder, Neonatal Opioid Withdrawal
Interventions
Night Respite Care
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Mattapan, Massachusetts • Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Recruiting Not applicable Interventional

Neuroplasticity in Maternal Opioid Use Disorder (OUD)

NCT05495984
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
ERPs with electroencephalography (EEG), MIO
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Sep 6, 2026, 9:08 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Prenatal Exposure Effects Psychophysiology Study

NCT01134770
View directory record Official record
Conditions
Pregnancy
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Drug Abuse Prevention Among Girls Through a Mother-Daughter Intervention

NCT01236248
View directory record Official record
Conditions
Substance Use
Interventions
Prevention
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
11 Years to 13 Years · Female only
Enrollment
916 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2017 · Synced Sep 6, 2026, 9:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

ACE, Resilience, and Substance Use Disorder: Maternal and Baby Outcomes in the First Year of Life

NCT05731557
View directory record Official record
Conditions
Adverse Childhood Experiences
Interventions
Not listed
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Brief Intervention in At-Risk First-time Mothers

NCT00230009
View directory record Official record
Conditions
Substance Use
Interventions
Brief motivational intervention
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 7, 2013 · Synced Sep 6, 2026, 9:08 AM EDT
Recruiting Not applicable Interventional

Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years

NCT05910580
View directory record Official record
Conditions
Alcohol-Related Disorders, Substance-Related Disorders, Mental Health, Reproductive Health, Sexual Health, Sexually Transmitted Diseases, Contraception, Maternal Health, Pregnancy, Women's Health
Interventions
Screening, Brief Intervention, and Referral to Treatment (SBIRT)
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Boston, Massachusetts • Marlborough, Massachusetts • Springfield, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Phase 2 Interventional Results available

Maternal Buprenorphine-naloxone Treatment and the Infant

NCT03291847
View directory record Official record
Conditions
Maternal Opioid Use Disorder, Opioid Exposed Infant
Interventions
fetal monitoring, Buprenorphine Naloxone
Device · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 44 Years · Female only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 25, 2024 · Synced Sep 6, 2026, 9:08 AM EDT
Recruiting Phase 2 Interventional

MDMA for Co-occurring PTSD and OUD After Childbirth

NCT05219175
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Opioid Use Disorder
Interventions
MDMA Assisted Therapy
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced Sep 6, 2026, 9:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoking Reduction In Gravid Substance Use Disorders

NCT04132232
View directory record Official record
Conditions
Tobacco Smoking in Mother Complicating Pregnancy, Tobacco Use Disorder, Tobacco Smoking
Interventions
knowledge of expired maternal carbon monoxide and fetal carboxyhemoglobin levels
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 4, 2024 · Synced Sep 6, 2026, 9:08 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

NCT03923374
View directory record Official record
Conditions
Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence
Interventions
Subutex / Buprenorphine, Fetal & Neonatal MRI, DNA/Genetic/Pharmacokenetic Blood Draws
Drug · Diagnostic Test
Lead sponsor
Senthil Sadhasivam
Other
Eligibility
18 Years and older · Female only
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 6, 2026, 9:08 AM EDT