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Showing 1–23 of 23 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mechanical Neck Pain Clear all
Completed Not applicable Interventional

Lidocaine Patch for Neck Pain

NCT04378959
View directory record Official record
Conditions
Neck Pain, Neck Pain, Posterior
Interventions
Lidocaine patch, Placebo patch
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 90 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional

Short-Term Effects of Combined Manual Therapy to the Cervical and Thoracic Spine

NCT01318720
View directory record Official record
Conditions
Neck Pain
Interventions
Manual Therapy
Other
Lead sponsor
Masefield and Cavallaro Physical Therapy
Other
Eligibility
18 Years to 60 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
2
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Jul 23, 2026, 5:31 AM EDT
Not listed No phase listed Observational

McKenzie Method of Mechanical Diagnosis and Therapy for Management of Cervicogenic Headache: A Prospective Case Series

NCT05212844
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Musculoskeletal Physical Therapy
Procedure
Lead sponsor
Faith Regional Health Services
Other
Eligibility
19 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Norfolk, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional

Development of a Clinical Prediction Rulefor Neck Manipulation

NCT01620905
View directory record Official record
Conditions
Mechanical Neck Pain
Interventions
Manipulation
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 60 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated May 11, 2016 · Synced Jul 23, 2026, 5:31 AM EDT
Not listed Not applicable Interventional

Cardiovascular Response to Two Manual Techniques for Neck Pain

NCT02198677
View directory record Official record
Conditions
Neck Pain
Interventions
Anterior to posterior pressures, Lateral glide
Procedure
Lead sponsor
Azusa Pacific University
Other
Eligibility
18 Years to 50 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Azusa, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2016 · Synced Jul 23, 2026, 5:31 AM EDT
Terminated No phase listed Observational

Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients

NCT02761928
View directory record Official record
Conditions
Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical, Benign Hypermobility Syndrome
Interventions
Beighton score for hypermobility
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neuroendocrine Changes in Cervical Spinal Manipulation and Mobilization Non-specific Mechanical Neck Pain

NCT04911608
View directory record Official record
Conditions
Neck Pain
Interventions
cervical spinal manipulation, cervical spinal mobilization
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Immediate Effects of Thoracic Transverse Mobilization in Patients With Primary Complaint of Mechanical Neck Pain: A Pilot Study

NCT02028741
View directory record Official record
Conditions
Mechanical Neck Pain
Interventions
Transverse vertebral pressures
Other
Lead sponsor
Robert Boyles
Other
Eligibility
18 Years to 60 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jan 6, 2014 · Synced Jul 23, 2026, 5:31 AM EDT
Not listed Not applicable Interventional

Thrust Manipulation vs. Non-thrust Mobilizations for Mechanical Neck Pain

NCT02619500
View directory record Official record
Conditions
Neck Pain
Interventions
Home Exercise Program, Patient advice, encouragement, and education, Thrust Manipulation, Non-thrust Mobilizations
Other
Lead sponsor
Youngstown State University
Other
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 11, 2016 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Benefit of Adding Stretching to Standard Intervention For Patients With Nonspecific Mechanical Neck Pain

NCT03194490
View directory record Official record
Conditions
Neck Pain
Interventions
combined intervention group, The standard intervention
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 60 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Oct 30, 2019 · Synced Jul 23, 2026, 5:31 AM EDT
Not listed Not applicable Interventional

Bio-mechanical Reasoning and Lateral Specificity of Upper Cervical Joint Mobilization

NCT04054869
View directory record Official record
Conditions
Neck Pain
Interventions
Bio-mechanically correct manual therapy at the cervical atlanto-axial joints, Bio-mechanically in-correct manual therapy at the cervical atlanto-axial joints
Other
Lead sponsor
Andrews University
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Avon, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 28, 2019 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Phase 1Phase 2 Interventional Results available

The Effectiveness of a Mechanical Manual Therapy Device in the Treatment of Neck Pain

NCT01168986
View directory record Official record
Conditions
Neck Pain
Interventions
Pulstar Multiple Impulse Therapy, Exercise
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 19, 2016 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Phase 2 Interventional

Chiropractic and Exercise for Seniors With Neck Pain

NCT00269308
View directory record Official record
Conditions
Neck Pain
Interventions
Chiropractic Manual treatment + home exercise ( procedure+behavior), Supervised rehabilitative exercise + home exercise, Home exercise
Procedure · Behavioral
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
65 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 22, 2011 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Phase 1 Interventional

Comparison of the Effectiveness of Mobilization and Manipulation of the Thoracic Spine in Patients With Mechanical Neck Pain

NCT00128869
View directory record Official record
Conditions
Neck Pain
Interventions
spine mobilizations, spine manipulations
Procedure
Lead sponsor
Newton-Wellesley Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
4
States / cities
San Diego, California • Colorado Springs, Colorado • Newton, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated May 12, 2008 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional

Using fMRI to Determine if Cerebral Hemodynamic Responses to Pain Change Following Thoracic Spine Manipulation in Individuals With Mechanical Neck Pain

NCT01862705
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spine manipulation
Other
Lead sponsor
OSF Healthcare System
Other
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Jul 23, 2026, 5:31 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Hormones, Outcomes, and Pain Pathways in Exercise Study

NCT07579182
View directory record Official record
Conditions
Breast Pain, Mastalgia, Back Pain, Back Pain, Low, Neck Pain, Chest Pain, Activity, Motor, Healthy Aging, Weight, Body, Inflammation, Gonadal Steroid Hormones, Neuronal Plasticity, Neuromuscular Manifestations
Interventions
Interventional Sports bra
Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Manipulation of the Cervical Spine on Pain Biomarkers

NCT03176654
View directory record Official record
Conditions
Neck Pain, Posterior
Interventions
HVLAT manipulation, Sham HVLAT manipulation
Procedure
Lead sponsor
Loma Linda University
Other
Eligibility
20 Years to 45 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Phase 3 Interventional

The Value of Traction in the Treatment of Cervical Radiculopathy

NCT00979108
View directory record Official record
Conditions
Radiculopathy, Neck Pain, Spinal Diseases, Musculoskeletal Diseases, Neuromuscular Diseases, Intervertebral Disk Displacement
Interventions
Physical therapy rehabilitation
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years to 70 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Lackland Air Force Base, Texas • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 16, 2014 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional

Cervical and Upper Thoracic Mobilization and Manipulation for Mechanical Neck Pain

NCT02036905
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical and thoracic mobilization, cervical and thoracic manipulation
Other
Lead sponsor
Youngstown State University
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Solon, Ohio • Havertown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Cervical Spine Manipulation on Gait

NCT02287324
View directory record Official record
Conditions
Cervicalgia
Interventions
Manipulation, Manual Contact
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 9, 2014 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Phase 2Phase 3 Interventional

Manual Physical Therapy and Exercise for Mechanical Neck Disorders

NCT00416117
View directory record Official record
Conditions
Neck Pain, Radiculitis
Interventions
Manual Physical Therapy and Exercise, Minimal Intervention
Procedure
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
2
States / cities
Fort Sam Houston, Texas • Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Dec 26, 2006 · Synced Jul 23, 2026, 5:31 AM EDT
Completed Not applicable Interventional

Short-Term Response of Thoracic Spine Manipulation With or Without Trigger Point Dry Needling for Mechanical Neck Pain

NCT02415660
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spinal manipulation, Trigger point dry needling, Cervical range of motion exercises, Posterior neck muscle activation exercise, Trigger point dry needling sham, Seirin J-type stainless steel needles, 0-2-0.3 x 40-50 mm
Procedure · Behavioral · Device
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Jul 23, 2026, 5:31 AM EDT
Not listed Not applicable Interventional

The Comparative Effectiveness of Interventions in People With Neck Pain Who Exhibit Directional Preference

NCT06160648
View directory record Official record
Conditions
Neck Pain
Interventions
Management according to Mechanical Diagnosis and Therapy, Management according to the Cervical Spine Clinical Practice Guidelines
Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Chicago, Illinois • Radnor, Pennsylvania • York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 6, 2023 · Synced Jul 23, 2026, 5:31 AM EDT