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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mechanical Ventilation Complication Clear all
Completed Not applicable Interventional

Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?

NCT01878968
View directory record Official record
Conditions
Congestive Heart Failure, Infections, Sepsis, Acute Renal Failure, Stroke
Interventions
Script and CPR/Mechanical ventilation video.
Other
Lead sponsor
Jewish Hospital, Cincinnati, Ohio
Other
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 5, 2016 · Synced Jul 23, 2026, 5:30 AM EDT
Recruiting Not applicable Interventional

Impact of Intraoperative Oxygenation Practices on Patient Outcomes

NCT07224243
View directory record Official record
Conditions
Surgeries Undergoing General Anesthesia
Interventions
Lower FiO2, Intermediate FiO2, Higher FiO2
Other
Lead sponsor
Frederic T Billings IV
Other
Eligibility
18 Years and older
Enrollment
54,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Ann Arbor, Michigan • Omaha, Nebraska • Nashville, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jul 23, 2026, 5:30 AM EDT
Terminated Phase 2 Interventional Results available

Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus

NCT03701074
View directory record Official record
Conditions
Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia
Interventions
Ibuprofen and acetaminophen, Ibuprofen and placebo
Drug
Lead sponsor
University of South Alabama
Other
Eligibility
5 Days to 21 Days
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Mobile, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Jul 23, 2026, 5:30 AM EDT
Terminated Not applicable Interventional Results available

Caffeine to Reduce Mechanical Ventilation in Preterm Infants

NCT01751724
View directory record Official record
Conditions
Prematurity, Apnea, Respiratory Failure
Interventions
Caffeine citrate, Normal saline
Drug · Other
Lead sponsor
University of Miami
Other
Eligibility
1 Day to 5 Days
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2017 · Synced Jul 23, 2026, 5:30 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Determinants of Implementation Success Coordinating Ventilator, Early Ambulation and Rehabilitation Efforts

NCT04249141
View directory record Official record
Conditions
Implementation Science, Delirium, Intensive Care Unit Acquired Weakness, Pain, Sedation Complication, Mechanical Ventilation Complication
Interventions
Survey and concept mapping
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Jul 23, 2026, 5:30 AM EDT
Completed No phase listed Observational

Preventing Failed Extubations

NCT06301867
View directory record Official record
Conditions
Mechanical Ventilation Complication, Weaning Failure
Interventions
Plateau Pressure
Diagnostic Test
Lead sponsor
Duke University
Other
Eligibility
18 Years to 120 Years
Enrollment
248 participants
Timeline
2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Jul 23, 2026, 5:30 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Little Lungs Study

NCT06855043
View directory record Official record
Conditions
Invasive Mechanical Ventilation, Severe Respiratory Distress Syndrome
Interventions
Calfactant, Budesonide
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
7 Days to 14 Days
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Jul 23, 2026, 5:30 AM EDT
Completed Not applicable Interventional Results available

Protocolized Post-Extubation Respiratory Support Study

NCT03288311
View directory record Official record
Conditions
Mechanical Ventilation Complication, Acute Respiratory Failure, Intubation Complication
Interventions
Protocolized post-extubation respiratory support, Usual Care
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
751 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 28, 2023 · Synced Jul 23, 2026, 5:30 AM EDT
Completed Not applicable Interventional Results available

Effect of Diaphragm Stimulation During Surgery

NCT03303040
View directory record Official record
Conditions
Mechanical Ventilation Complication, Diaphragm Injury
Interventions
Electrical stimulation of hemidiaphragm
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Jul 23, 2026, 5:30 AM EDT
Terminated Not applicable Interventional Results available

Entrainment-Based Mechanical Ventilation

NCT03512067
View directory record Official record
Conditions
Respiratory Insufficiency, Respiratory Failure, Mechanical Ventilation Complication
Interventions
Patients given EMV Ventilation
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 10, 2019 · Synced Jul 23, 2026, 5:30 AM EDT
Completed Not applicable Interventional

Early Identification and Prevention of Extubation Failure in Adults Using Integrated Pulmonary Index

NCT04231890
View directory record Official record
Conditions
Mechanical Ventilation Complication, Extubation
Interventions
IPI monitoring
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced Jul 23, 2026, 5:30 AM EDT
Recruiting No phase listed Observational

Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).

NCT05412810
View directory record Official record
Conditions
Mechanical Ventilation Complication, Hyperoxia
Interventions
oxygen
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 110 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Jul 23, 2026, 5:30 AM EDT
Terminated Phase 3 Interventional

Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)

NCT00005777
View directory record Official record
Conditions
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
Interventions
Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone, Placebo
Procedure · Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
5 Minutes to 10 Days
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2002
U.S. locations
13
States / cities
Birmingham, Alabama • Palo Alto, California • New Haven, Connecticut + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Jul 23, 2026, 5:30 AM EDT
Completed No phase listed Observational

Assessment of Ventilatory Management During General Anesthesia for Robotic Surgery

NCT02989415
View directory record Official record
Conditions
Robotic Surgery, Mechanical Ventilation
Interventions
Mechanical Ventilation
Other
Lead sponsor
Hospital Israelita Albert Einstein
Other
Eligibility
18 Years and older
Enrollment
1,015 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
4
States / cities
San Francisco, California • Boston, Massachusetts • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Jul 23, 2026, 5:30 AM EDT
Completed Not applicable Interventional

Cognitive Behavioral Therapy for Mechanical Ventilation Wean

NCT04763590
View directory record Official record
Conditions
Anxiety, Cognitive Behavioral Therapy, Mechanical Ventilation Complication
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
Up to 100 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Jul 23, 2026, 5:30 AM EDT
Completed Not applicable Interventional Results available

Endotracheal Tube Securement Study

NCT03760510
View directory record Official record
Conditions
Mechanical Ventilation Complication
Interventions
Tube Fastener, Adhesive Tape
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced Jul 23, 2026, 5:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Mode of Transport Ventilation on Respiratory Parameters After Cardiac Surgery

NCT02740075
View directory record Official record
Conditions
Complication of Ventilation Therapy
Interventions
Not listed
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Jul 23, 2026, 5:30 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients

NCT03139695
View directory record Official record
Conditions
Injury of Diaphragm, Mechanical Ventilation Complication, Critical Illness
Interventions
Ultrasound
Diagnostic Test
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Jul 23, 2026, 5:30 AM EDT
Completed No phase listed Observational

Transpulmonary Pressures in Mechanical Ventilated Patients With Morbid Obesity

NCT02309190
View directory record Official record
Conditions
Mechanical Ventilation Complication, Respiratory Insufficiency
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Jul 23, 2026, 5:30 AM EDT
Completed No phase listed Observational

Ketamine Infusion as Sedative Analgesic in Severe ARDS

NCT04818827
View directory record Official record
Conditions
Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
Interventions
Not listed
Lead sponsor
Interfaith Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Jul 23, 2026, 5:30 AM EDT
Not listed Not applicable Interventional

Efficacy of Oxepa Enteral Feeding in LTAC (Long Term Acute Care Hospital) Patients on Chronic Ventilation- a Pilot Study

NCT02208700
View directory record Official record
Conditions
Acute Lung Injury, Mechanical Ventilation Complication, Dietary Modification
Interventions
Oxepa, Jevity 1.5
Other
Lead sponsor
Grace Hospital, Cleveland, Ohio
Other
Eligibility
19 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 4, 2014 · Synced Jul 23, 2026, 5:30 AM EDT
Completed Phase 1Phase 2 Interventional

Delivery Room CPAP in Extremely Low Birth Weight Infants

NCT01223274
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Bronchopulmonary Dysplasia, Continuous Positive Airway Pressure
Interventions
CPAP/PEEP, Standard management practices
Device
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 10 Minutes
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
6
States / cities
Birmingham, Alabama • San Diego, California • Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 23, 2026, 5:30 AM EDT
Active, not recruiting Not applicable Interventional

CT for Personalized Mechanical Ventilation

NCT05977153
View directory record Official record
Conditions
Ventilator-Induced Lung Injury, Sepsis Syndrome, Mechanical Ventilation Complication
Interventions
PEEP (positive end-expiratory pressure) - maximum, PEEP (positive end-expiratory pressure) - standard
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Jul 23, 2026, 5:30 AM EDT
Completed Not applicable Interventional

A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults

NCT03972384
View directory record Official record
Conditions
Critical Illness, Mechanical Ventilation Complication, Delirium, Cognitive Impairment
Interventions
Post-ICU Problem Solving
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
55 Years to 89 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 24, 2024 · Synced Jul 23, 2026, 5:30 AM EDT