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Showing 1–24 of 34 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mechanically Ventilated ICU Patients Clear all
Completed Phase 4 Interventional

A Safety and Efficacy Study of Dexmedetomidine in ICU Patients Requiring Continuous Sedation

NCT00216190
View directory record Official record
Conditions
Mechanically Ventilated and Intubated Subjects
Interventions
Dexmedetomidine HCL Injection, Midazolam Injection
Drug
Lead sponsor
Hospira, now a wholly owned subsidiary of Pfizer
Industry
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
78
States / cities
Birmingham, Alabama • Chandler, Arizona • Phoenix, Arizona + 75 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2015 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Not applicable Interventional

The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status

NCT00469482
View directory record Official record
Conditions
Delirium, Cognitive Impairment, Critically Ill
Interventions
Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 7, 2018 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Not applicable Interventional Results available

Eye-Control Trial: Wearable Eye-Tracking Device as Means of Communication

NCT04582149
View directory record Official record
Conditions
Acute Respiratory Failure Requiring Mechanical Ventilation
Interventions
EyeControl Eye-tracking Device
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Not applicable Interventional Results available

Effect of EPA and HMB on Strength in ICU Patients

NCT01270516
View directory record Official record
Conditions
Muscle Weakness
Interventions
HMB, hydroxymethylbutyrate, EPA, eicosapentaenoic acid, Saline
Drug
Lead sponsor
Gerald Supinski
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 11, 2021 · Synced Jul 22, 2026, 10:42 AM EDT
Terminated Phase 2 Interventional

Pharmacokinetics, Pharmacodynamics and Safety Evaluation of SAR279356 in Intensive Care Unit Mechanically Ventilated Patients

NCT01389700
View directory record Official record
Conditions
Infection Prophylaxis
Interventions
SAR279356, placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
6
States / cities
Los Angeles, California • Stanford, California • Jacksonville, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2014 · Synced Jul 22, 2026, 10:42 AM EDT
Terminated Not applicable Interventional

Brain Computer Interface for Communication in Ventilated Patients

NCT02791425
View directory record Official record
Conditions
Mechanical Ventilation, Nonverbal Communication, Intratracheal Intubation, Critical Illness
Interventions
Brain Computer Interface (BCI) device, Communication picture board
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Jul 22, 2026, 10:42 AM EDT
Terminated Phase 1 Interventional

How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units

NCT00826553
View directory record Official record
Conditions
Delirium, Respiratory Failure
Interventions
Dexmedetomidine, GABA agonist
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 4, 2017 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Phase 3 Interventional

Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients

NCT05456542
View directory record Official record
Conditions
Respiratory Failure
Interventions
Cuff Leak Test, Dexamethasone 4mg
Diagnostic Test · Drug
Lead sponsor
St. Joseph's Healthcare Hamilton
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2025 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Not applicable Interventional Results available

Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness

NCT00709124
View directory record Official record
Conditions
Intensive Care Unit, Muscle Weakness
Interventions
Neuromuscular Electrostimulation (NMES) CareStim Muscle Stimulation Device (Care Rehab; McLean, VA), Sham
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Jul 22, 2026, 10:42 AM EDT
Terminated No phase listed Observational

Effects of Obesity on Care and Outcomes in Mechanically Ventilated Individuals in the Intensive Care Unit

NCT00296088
View directory record Official record
Conditions
Obesity, Respiratory Insufficiency
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
582 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2013 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Not applicable Interventional

Testing a Novel Manual Communication System for Mechanically Ventilated ICU Patients

NCT04105751
View directory record Official record
Conditions
Communication, Ventilation Therapy; Complications
Interventions
Novel Communication System
Device
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 30, 2023 · Synced Jul 22, 2026, 10:42 AM EDT
Completed No phase listed Observational

COVID-19 Mortality Prediction Model

NCT04358510
View directory record Official record
Conditions
COVID-19, Pneumonia, Mechanical Ventilation
Interventions
COViage
Device
Lead sponsor
Dascena
Industry
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2020 · Synced Jul 22, 2026, 10:42 AM EDT
Withdrawn Phase 2 Interventional

The Effect of Sodium Oxybate on Sleep Architecture

NCT00744393
View directory record Official record
Conditions
Mechanically Ventilated ICU Patients
Interventions
sodium oxybate, placebo
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Not applicable Interventional

Pilot: Feasibility of Intermittent Enteral Feeding in Ventilated MICU Patients

NCT04164108
View directory record Official record
Conditions
Nutrition
Interventions
Intermittent Enteral Nutrition Protocol
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 24, 2021 · Synced Jul 22, 2026, 10:42 AM EDT
Completed No phase listed Observational

ICU Liberation: Does Enhanced Patient Mobilization Improve Outcomes?

NCT03329924
View directory record Official record
Conditions
Early Mobilization of Mechanically Ventilated Patients
Interventions
Activity level measurement by accelerometer
Other
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Not applicable Interventional Results available

Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit

NCT01848158
View directory record Official record
Conditions
Agitation
Interventions
acupuncture, sham acupuncture
Device
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
6 Months to 17 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Jul 22, 2026, 10:42 AM EDT
Active, not recruiting Phase 3 Interventional

A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intravenous Propofol

NCT06809218
View directory record Official record
Conditions
Post-Intensive Care Syndrome, Sedation
Interventions
Inhaled isoflurane administered by Sedaconda ACD-S, Intravenous infusion of propofol
Drug
Lead sponsor
Sedana Medical
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Jul 22, 2026, 10:42 AM EDT
Withdrawn Not applicable Interventional

Evaluation of an Analgosedation Protocol in Mechanically Ventilated Patients

NCT02100735
View directory record Official record
Conditions
Effect of Protocolized Sedation on Days of Mechanical Ventilation in the ICU
Interventions
Sedation protocol
Other
Lead sponsor
Tampa General Hospital
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Riverview, Florida
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Jul 22, 2026, 10:42 AM EDT
Completed No phase listed Observational

Ketamine Infusion as Sedative Analgesic in Severe ARDS

NCT04818827
View directory record Official record
Conditions
Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
Interventions
Not listed
Lead sponsor
Interfaith Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 25, 2021 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Receptive Music Therapy in the ICU

NCT03931733
View directory record Official record
Conditions
Critical Illness
Interventions
Music Therapy
Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Leesburg, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2021 · Synced Jul 22, 2026, 10:42 AM EDT
Recruiting Not applicable Interventional

STimulation to Activate RespIration

NCT06832306
View directory record Official record
Conditions
ARDS (Moderate or Severe), AHRF, Mechanically Ventilated ICU Patients
Interventions
Phrenic Nerve Stimulation
Device
Lead sponsor
Lungpacer Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
6
States / cities
La Jolla, California • Shreveport, Louisiana • Winston-Salem, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Phase 2 Interventional

CYCLE Pilot Randomized Trial

NCT02377830
View directory record Official record
Conditions
Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
Interventions
In-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy
Device · Other
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 4, 2022 · Synced Jul 22, 2026, 10:42 AM EDT
Completed Phase 2 Interventional

Early Directed Physical Therapy in the Management of Mechanically Ventilated Patients in a Medical Intensive Care Unit

NCT00322010
View directory record Official record
Conditions
Mechanically Ventilated Patients
Interventions
early PT OT
Procedure
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2014 · Synced Jul 22, 2026, 10:42 AM EDT
Terminated Early Phase 1 Interventional

Convalescent Plasma in ICU Patients With COVID-19-induced Respiratory Failure

NCT04353206
View directory record Official record
Conditions
Covid-19, Sars-CoV2
Interventions
Multiple Doses of Anti-SARS-CoV-2 convalescent plasma
Biological
Lead sponsor
Noah Merin
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
2
States / cities
Los Angeles, California • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 7, 2021 · Synced Jul 22, 2026, 10:42 AM EDT