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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Median Nerve Compression Clear all
Withdrawn Phase 2 Interventional

Botulinum Toxin for Carpal Tunnel Syndrome

NCT00701233
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Botulinum toxin, Corticosteroid injection into Carpal Tunnel
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Jun 26, 2026, 7:32 AM EDT
Not listed Phase 2 Interventional

Influence of Pronator Teres Release on Treatment of Median Nerve Compression Neuropathy

NCT01562860
View directory record Official record
Conditions
Median Nerve Compression
Interventions
Pronator Teres Release, dual compression release, median nerve release only
Procedure
Lead sponsor
Christine M. Kleinert Institute for Hand and Microsurgery
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Jun 26, 2026, 7:32 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries

NCT02313675
View directory record Official record
Conditions
Postoperative Pain, Carpal Tunnel Release, Distal Radius Fracture
Interventions
Acetaminophen, Ketorolac Tromethamine, Saline
Drug
Lead sponsor
John Fowler
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced Jun 26, 2026, 7:32 AM EDT
Not listed Phase 2 Interventional

Carpal Tunnel Syndrome and Static Magnetic Field Therapy

NCT00521495
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
neodymium permanent magnet, neodymium magnet, magnet
Device
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 24, 2009 · Synced Jun 26, 2026, 7:32 AM EDT
Suspended Early Phase 1 Interventional Accepts healthy volunteers

Lipografting Versus Steroid Injections for Treatment of Carpal Tunnel Syndrome

NCT03722303
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Fat Injection, Steroid Injection
Other · Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Jun 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sonographic Measurement of Intraneural Blood Flow in the Median Nerve

NCT05057754
View directory record Official record
Conditions
Carpal Tunnel Syndrome, Median Nerve Injury
Interventions
Cooling, Heating, Exercising, Typing, Using a mouse, Cooking
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
2
States / cities
Los Angeles, California • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jun 26, 2026, 7:32 AM EDT
Completed No phase listed Observational

Novel Decision Aid for Carpal Tunnel Patients

NCT04693273
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Decision Aid for Surgical Modality Choice
Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Jun 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional

Prospective Randomized Trial of Monocryl Versus Nylon Suture Closure in Carpal Tunnel Surgery

NCT03950401
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Monocryl, Nylon
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Jun 26, 2026, 7:32 AM EDT
Enrolling by invitation Not applicable Interventional

Assessment of Carpal Tunnel Syndrome by Shearwave Elastography

NCT04804293
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
FDA approved ultrasound system with shear wave elastography capability
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jun 26, 2026, 7:32 AM EDT
Recruiting Not applicable Interventional

Effect of Cooling Therapy for Post-Operative Pain in Open Carpal Tunnel Release

NCT05783245
View directory record Official record
Conditions
Carpal Tunnel Syndrome, Perioperative/Postoperative Complications
Interventions
Polarcare Machine, Standard of care ice therapy
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jun 26, 2026, 7:32 AM EDT
Terminated No phase listed Observational

Corticosteroid Injection as a Predictor of Outcome in Carpal Tunnel Release

NCT00655915
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Corticosteroid Injection- 1ml of Betamethasone and 1 ml of 1% Lidocaine
Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 8, 2011 · Synced Jun 26, 2026, 7:32 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Avazzia HVPC Bio-Electrical Stimulation Technology (BEST™) Microcurrent CTS RCT

NCT04271319
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
BEST™ HVPC microcurrent electrical stimulation PRO-SPORT Ultra® Device, Sham PRO-SPORT Ultra® Device
Device
Lead sponsor
Avazzia, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2021 · Synced Jun 26, 2026, 7:32 AM EDT
Recruiting Not applicable Interventional

Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome

NCT04206215
View directory record Official record
Conditions
Chronic Pain, Carpal Tunnel Syndrome
Interventions
transcranial Direct Current Stimulation (tDCS), Transcranial Ultrasound (TUS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jun 26, 2026, 7:32 AM EDT
Completed Phase 2 Interventional Results available

BOTOX® (Onabotulinumtoxin A) Injection(s) as a Treatment for Carpal Tunnel Syndrome

NCT02070302
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Botulinum Toxin Type A, Placebo
Drug
Lead sponsor
Benjamin Sucher
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 26, 2017 · Synced Jun 26, 2026, 7:32 AM EDT
Recruiting No phase listed Observational

Corticosteroid Injection Effectiveness in Carpel Tunnel Patients With Negative or Mild EMG Studies

NCT04737239
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Corticosteroid injections for CTS treatment
Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jun 26, 2026, 7:32 AM EDT
Recruiting Not applicable Interventional

Carpal Arch Space Augmentation (CASA) Clinical Trial

NCT06208709
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
carpal arch space augmentation (CASA), standard of care (SOC)
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Jun 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional

Patient Outcomes With Endoscopic Versus Open Carpal Tunnel Release

NCT00880295
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
endoscopic carpal tunnel release, open carpal tunnel release
Procedure
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 75 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Jun 26, 2026, 7:32 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Wound Closure Study in Carpal Tunnel and Trigger Finger Surgery

NCT03781141
View directory record Official record
Conditions
Carpal Tunnel Syndrome, Trigger Finger
Interventions
Wound closure
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Jun 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of High-quality Pre-operative Videos on Patient Anxiety Levels Prior to Ambulatory Hand Surgery

NCT04424810
View directory record Official record
Conditions
Anxiety, Carpal Tunnel Syndrome, Trigger Finger, Engagement, Patient, Pain
Interventions
High-quality, physician created video, Standard of care
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Jun 26, 2026, 7:32 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ultrasound Analysis of Human Carpal Tunnel System

NCT02747836
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Ultrasound of the wrist
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
257 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jun 26, 2026, 7:32 AM EDT
Terminated Phase 4 Interventional Results available

Patient Satisfaction With Pain Relief After Ambulatory Hand Surgery

NCT01588158
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
Acetaminophen, Vicodin
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Jun 26, 2026, 7:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Non-surgical Intervention for Carpal Tunnel Syndrome

NCT03360344
View directory record Official record
Conditions
Carpal Tunnel Syndrome, Susceptibility to
Interventions
Kinesio 12 inch Tape, Kinesio 4 inch Tape, Cock up Splint and Lumbrical exercises
Device
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 99 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Jun 26, 2026, 7:32 AM EDT
Not yet recruiting Not applicable Interventional

Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test

NCT07158892
View directory record Official record
Conditions
Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS), Lateral Epicondylitis, Osteoarthritis, Trigger Digit, Dupuytren Contracture, Rotator Cuff Tendinopathy, De Quervain Disease
Interventions
Diagnostic Advance Care Planning Discussion, Informational Statement Only
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Jun 26, 2026, 7:32 AM EDT
Recruiting Not applicable Interventional

Comparing Efficacy of Osteopathic Manipulation vs. Wrist Immobilization for Carpal Tunnel Syndrome

NCT07432750
View directory record Official record
Conditions
Carpal Tunnel Syndrome (CTS)
Interventions
Osteopathic Manipulative Treatment, Wrist Immobilizer
Procedure · Device
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jun 26, 2026, 7:32 AM EDT