Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 12, 2026, 12:05 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 217–240 of 442 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Medication Abuse Clear all

Conditions: Alcohol Abuse
Interventions: Brief Negotiated Interview, General Health Information; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 65 Years and older
Enrollment: 222 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Alcoholism, Alcohol Abuse, Alcohol Dependence
Interventions: Dutasteride, Placebo; Drug
Lead sponsor: UConn Health; Other
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use, Substance Use, Methamphetamine Abuse, Methamphetamine-dependence
Interventions: App-Based Contingency Management, Sham Control; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Oconomowoc, Wisconsin • Wauwatosa, Wisconsin

Conditions: Smoking, Cannabis
Interventions: cannabis; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 3
States / cities: New Haven, Connecticut

Conditions: Drug Addiction
Interventions: Zolpidem extended-release, MET/CBT; Drug · Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 127 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Abuse, Intravenous
Interventions: Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Hepatitis C, Medication Adherence
Interventions: Intensive Models (mDOT and CGT) of HCV Care; Other
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Cocaine Addiction, Cocaine Dependence
Interventions: Vigabatrin, Matching Placebo; Drug
Lead sponsor: Catalyst Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 207 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 13
States / cities: Los Angeles, California • Torrance, California • Denver, Colorado + 10 more

Conditions: Substance Abuse
Interventions: Motivational interviewing, Strengths-Based Case Management; Behavioral
Lead sponsor: Wright State University; Other
Eligibility: 18 Years and older
Enrollment: 678 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2008
U.S. locations: 1
States / cities: Dayton, Ohio

Conditions: Feedback, Psychological, Clinical Trial, Substance Abuse
Interventions: Web-based PFI, Assessment Only; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 25 Years
Enrollment: 843 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: HIV, Opioid Abuse
Interventions: Standard Care, Text Messaging CBT (TXT-CBT); Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Opioid Use, Prescription Drug Abuse and Dependency, Surgery, Postoperative Pain
Interventions: No opioids at discharge; Behavioral
Lead sponsor: Albany Medical College; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Albany, New York

Conditions: Drug Abuse, Cocaine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cocaine Dependence
Interventions: Ondansetron, Placebo; Drug
Lead sponsor: University of Virginia; Other
Eligibility: 18 Years and older
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 2
States / cities: Charlottesville, Virginia • Richmond, Virginia

Conditions: Substance Abuse, HIV
Interventions: Tool to provide re-entry support and improve linkage to healthcare and social services; Behavioral
Lead sponsor: Temple University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Healthy Volunteer
Interventions: Alprazolam Placebo, Cenobamate placebo, Alprazolam, Cenobamate; Drug
Lead sponsor: SK Life Science, Inc.; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Substance-Related Disorders
Interventions: Behavior Therapy; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 99 Years
Enrollment: 390 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2003
U.S. locations: 7
States / cities: Bakersfield, California • Washington D.C., District of Columbia • Baltimore, Maryland + 3 more

Conditions: Prevention Harmful Effects
Interventions: computer-facilitated brief intervention; Behavioral
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 9 Years to 18 Years
Enrollment: 871 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 5
States / cities: Boston, Massachusetts • East Boston, Massachusetts • Lexington, Massachusetts

Conditions: Opioid Related Disorders, Opioid Dependence, Opioid Addiction
Interventions: Buprenorphine/naloxone, Clonidine, Tramadol ER; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Abuse, Risk Reduction, RIsky Sexual Behavior
Interventions: Handbook condition, Handbook plus condition; Behavioral
Lead sponsor: Washington State University; Other
Eligibility: 17 Years to 22 Years
Enrollment: 910 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Pullman, Washington

Conditions: Polysubstance Abuse, Opioid Use, Tobacco Use
Interventions: MORE and MI and NRT, MORE and No MI and NRT, Support Group and MI and NRT, Support Group and No MI and NRT; Other
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 420 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 2
States / cities: New Brunswick, New Jersey • Salt Lake City, Utah

Conditions: Drug Abuse
Interventions: Ramelteon, triazolam, and placebo (56 possible combinations total); Drug
Lead sponsor: Takeda; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Alcohol Use Disorder, Substance Use Disorders, Alcohol Use Complicating Pregnancy, Unspecified Trimester, Drug Use Disorders, Drug Use Complicating Pregnancy, Unspecified Trimester
Interventions: Parent-Child Assistance Program - One-Year Version; Behavioral
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Enid, Oklahoma • Oklahoma City, Oklahoma

Conditions: Substance Abuse
Interventions: Free2b, Attention-Placebo; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 15 Years to 17 Years
Enrollment: 1,216 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: New York, New York

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Study of an Emergency Department-based Intervention to Reduce Alcohol Misuse in Older Adults

Dutasteride for the Reduction of Alcohol Use in Male Drinkers

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

Imaging the Neurochemistry of Drug Addiction With PET

The Role of Sleep in the Treatment of Cannabis Use Disorders

The Long-Term Treatment of Drug Addiction and Unemployment

Intensive Models of HCV Care for Injection Drug Users

Vigabatrin for the Treatment of Cocaine Dependency

Reducing Barriers to Drug Abuse Treatment Services

Personalized Health Assessment Related to Medications (Project PHARM)

Cell Phone Technology Targeting ART Adherence and Drug Use

No Opioids PrescrIptions On Discharge After Surgery

Reward Processing in Cocaine Addiction

New Medication Treatment for Stimulant Dependence

Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System

A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users

Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics. - 1

Computerized Alcohol Screening for Children and Adolescents (cASCA) in Primary Care

Medications Development for Drug Abuse Disorders

First Years Away From Home: Letting Go and Staying Connected

Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement

Behavioral and Subjective Efficacy of Ramelteon in Subjects With a History of Polydrug Abuse

Evaluating a One-Year Version of the Parent-Child Assistance Program

Preventing Drug Abuse Among Sexual Minority Youth