Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 14, 2026, 6:09 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 409–432 of 442 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Medication Abuse Clear all

Conditions: Medical Education
Interventions: Online education; Behavioral
Lead sponsor: Medical Directions, Inc; Industry
Eligibility: Not listed
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Relationship, Family (Foster), Substance Use Prevention
Interventions: Connecting; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 11 Years to 15 Years
Enrollment: 220 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Opioid Use Disorder, Methamphetamine Abuse, Cocaine Use Disorder
Interventions: DynamiCare app (app-based contingency management), Sham control; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Chicago, Illinois • Milwaukee, Wisconsin

Conditions: Substance-Related Disorders, Drug Addiction, Substance Abuse
Interventions: Home-Based Intervention, Educational Group; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 12 Years to 19 Years
Enrollment: 286 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2016
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Healthy Volunteer
Interventions: Alprazolam Placebo, Cenobamate placebo, Alprazolam, Cenobamate; Drug
Lead sponsor: SK Life Science, Inc.; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Substance Abuse
Interventions: Free2b, Attention-Placebo; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 15 Years to 17 Years
Enrollment: 1,216 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Drug/Substance Abuse/Addiction, Alcohol Abuse/Addiction
Interventions: Oxford House, Safe Haven, Usual aftercare; Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years and older
Enrollment: 270 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2013
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Alcohol Dependence (Primary Condition), Alcohol Abuse
Interventions: Memantine; Drug
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: New York, New York

Conditions: Drug Abuse, Intoxication by Drug, Impairment
Interventions: Placebo, THC, CBD, THC + CBD; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 55 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Alcoholism, Alcohol Abuse, Smoking, Alcohol Drinking
Interventions: Varenicline; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 2
States / cities: New Haven, Connecticut • New York, New York

Conditions: Abuse Potential
Interventions: gabapentin 600 mg, gabapentin 1200 mg, gabapentin 1800 mg, diazepam 20 mg, placebo; Drug · Other
Lead sponsor: Viatris Specialty LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Drug Overdose, Substance Abuse, Alcohol Abuse
Interventions: Observational EEG Monitoring; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: HIV Infections
Interventions: Not listed
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: Ends 2008
U.S. locations: 12
States / cities: Los Angeles, California • San Francisco, California • Denver, Colorado + 8 more

Conditions: Substance Abuse, Intravenous
Interventions: Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Substance Use Disorders, Drug Abuse, Alcohol Abuse, Posttraumatic Stress Disorder, PTSD, Recidivism, Depression
Interventions: Cognitive Processing Therapy, Control Group; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 2
States / cities: Osceola, Arkansas • West Memphis, Arkansas

Conditions: Cannabis, Alcohol Effect, Driving Under the Influence of Alcohol and Other Drugs
Interventions: Active inhaled delta-9-THC, Placebo, Active Oral Ethanol; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Nicotine Dependence, Drug Abuse
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: HIV, AIDS, Substance Abuse, Inpatient
Interventions: Patient Navigation (PN) Group, Patient Navigator Plus Contingency Management (PN+CM) Group; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 801 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 12
States / cities: Birmingham, Alabama • Torrance, California • Miami, Florida + 8 more

Conditions: Cannabis, Marijuana Abuse
Interventions: drug condition; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
Interventions: LST High School Hybrid; Behavioral
Lead sponsor: National Health Promotion Associates, Inc.; Industry
Eligibility: 14 Years to 18 Years
Enrollment: 1,804 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Substance Abuse Detection, HIV, Hepatitis B, Hepatitis C, Brief Intervention, HIV Infections
Interventions: Brief motivational intervention; Behavioral
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 1,030 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Cocaine Dependence, Cocaine Abuse
Interventions: Contingency Management; Behavioral
Lead sponsor: Treatment Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 166 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Prescription Drug Abuse (Not Dependent)
Interventions: prescription drug-abuse education smartphone application; Behavioral
Lead sponsor: Naval Health Research Center; Federal
Eligibility: 18 Years to 55 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: San Diego, California

Conditions: Substance Abuse, Substance Dependence, Depressive Disorder
Interventions: Group interpersonal psychotherapy (IPT-G), Psychoeducation on co-occurring disorders (PSYCHOED); Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Cranston, Rhode Island

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Online Primary Care Physician (PCP) Training in Screening, Brief Intervention, Referral, and Treatment

A Trial of Connecting to Promote Foster Teen Well-Being

Contingency Management for Drug Use: Does Age Matter?

Home-Based Program to Help Parents of Drug Abusing Adolescents

A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users

Preventing Drug Abuse Among Sexual Minority Youth

Evaluating Alternative Aftercare Models for Ex-offenders

A Placebo-Controlled Trial of Memantine for Alcohol Dependence

Evaluation of Oral THC and CBD in Men and Women

Varenicline Treatment of Alcohol Dependence in Smokers

Evaluating the Abuse Potential of NEURONTIN® When Taken Orally in Healthy Non-drug Dependent Participants With Sedative Drug Abuse Experience

EEG Monitoring in the Emergency Department

A Study of HIV in Newly Infected Individuals

The Long-Term Treatment of Drug Addiction and Unemployment

Leveraging Implementation Science to Increase Access to Trauma Treatment for Incarcerated Drug Users

Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study I

Effects of Nicotine on Brain Activity as Measured by fMRI

Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users

Dronabinol Interactions With Cognitive Enhancing Drug in Humans

A High School Program for Preventing Prescription Drug Misuse

Brief Intervention for Drug Misuse in the Emergency Department

Long Term Maintenance of Drug Abstinence

Mobile Application for Prescription Drug-Abuse Education (MAPDE)

Group Therapy for Women Prisoners With Comorbid Substance Use and Depression