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ClinicalTrials.gov public records Last synced Nov 12, 2026, 2:06 AM EST

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Showing 145–168 of 442 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Medication Abuse Clear all

Conditions: Cannabis Use Disorder, PREG1, Drug Use, Fetal Exposure During Pregnancy, Neurodevelopmental Abnormality
Interventions: no intervention, this is a purely observational study; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years and older · Female only
Enrollment: 168 participants
Timeline: 2018 – 2020
U.S. locations: 2
States / cities: Aurora, Colorado • Denver, Colorado

Conditions: Substance Use Disorders, Risk Behavior, Psychiatric Disorders, Family Dysfunction
Interventions: Family Therapy based on Structural Family Therapy, Group Therapy, Psychoeducational Sessions, Individual Adolescent Therapy Sessions; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 14 Years to 17 Years
Enrollment: 190 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Feedback, Psychological, Clinical Trial, Substance Abuse
Interventions: Web-based PFI, Assessment Only; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 25 Years
Enrollment: 843 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Suicide, Alcohol Abuse, Drug Abuse, HIV
Interventions: Prevention program; Behavioral
Lead sponsor: George Mason University; Other
Eligibility: 13 Years to 18 Years
Enrollment: 81 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Alcohol Abuse, Drug Abuse
Interventions: Levetiracetam (Keppra), Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 50 Years
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Berkeley, California

Conditions: Drug Abuse
Interventions: Prevention Program; Behavioral
Lead sponsor: Columbia University; Other
Eligibility: 12 Years to 15 Years
Enrollment: 678 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Alcohol Abuse, Substance Use
Interventions: Bright Horizons, Case Management; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 10 Years to 24 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Whiteriver, Arizona

Conditions: Hepatitis C, Medication Adherence
Interventions: Intensive Models (mDOT and CGT) of HCV Care; Other
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Drug Use Disorder, Opioid Dependence, Opioid-Related Disorders, Opioid Use, Opioid Abuse
Interventions: fMRI; Diagnostic Test
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 2
States / cities: Hartford, Connecticut • New Haven, Connecticut

Conditions: Heroin Dependence, Opiate Dependence, Substance Dependence
Interventions: CRAFT-T, Treatment as usual; Behavioral
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years and older
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cocaine Dependence
Interventions: Oxytocin, Saline; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 65 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Alcohol Abuse
Interventions: Brief Negotiated Interview, General Health Information; Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 65 Years and older
Enrollment: 222 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Neonatal Abstinence Syndrome
Interventions: Stochastic Vibrotactile Stimulation (SVS); Device
Lead sponsor: Elisabeth B Salisbury; Other
Eligibility: 1 Hour to 18 Months
Enrollment: 208 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Opioid-Related Disorders, Substance-Related Disorders
Interventions: oxycodone 15 mg, oxycodone 30 mg, Placebo 0 mg; Drug
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 21 Years to 45 Years
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Opioid Abuse, Prescription Drug Abuse (Not Dependent)
Interventions: Not listed
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 1,464 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 2
States / cities: Cincinnati, Ohio • Salt Lake City, Utah

Conditions: Alcohol-related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse
Interventions: Naltrexone, Modified Behavioral Self-Control Psychotherapy, Brief Behavioral Compliance Enhancement Therapy; Drug · Behavioral
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Cocaine Abuse
Interventions: Treatment as usual (TAU), CBT for CBT; Other · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cocaine Abuse, Cocaine Dependence
Interventions: Cocaine, n-Acetylcysteine, Placebo; Drug
Lead sponsor: University of Kentucky; Other
Eligibility: 18 Years to 55 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Drug Abuse, Nicotine Dependence
Interventions: MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner; Device
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 80 Years
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Recreational Drug Use, Sexual Violence, Victimisation, Depressive Symptoms, Anxiety, Suicidal Ideation, Risk-Taking, Alcohol Drinking
Interventions: Teen Connection Project (TCP); Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 14 Years and older
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Marijuana Dependence
Interventions: eszopiclone, Placebo, ramelteon, zolpidem; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder, Methamphetamine Abuse, Cocaine Use Disorder
Interventions: DynamiCare app (app-based contingency management), Sham control; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Chicago, Illinois • Milwaukee, Wisconsin

Conditions: Cannabis
Interventions: iTBS; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2029
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence, Drug Abuse
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

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The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity

Culturally Informed Family Based Treatment of Adolescents: A Randomized Trial

Personalized Health Assessment Related to Medications (Project PHARM)

Alcohol, Suicide and HIV Prevention for Teens in Mental Health Treatment

Effects of Levetiracetam (Keppra) on Alcohol Consumption

Preventing Drug Abuse Among Hispanic Adolescents

Adaptation and Evaluation of Bright Horizons

Intensive Models of HCV Care for Injection Drug Users

fMRI and Opioid Abstinence

Community Reinforcement and Family Training for Drug Abuse Treatment Retention/HIV Risk Reduction

Oxytocin in Cocaine Dependence

Study of an Emergency Department-based Intervention to Reduce Alcohol Misuse in Older Adults

Efficacy and Outcomes of a Non-Pharmacological Intervention for Neonatal Abstinence Syndrome

Prescription Opioid Effects in Abusers Versus Non-Abusers

Validation of a Community Pharmacy-Based Prescription Drug Monitoring Program Risk Screening Tool

Medication and Counseling for Controlled Drinking (Project SMART)

Computer-Based Training in Cognitive Behavior Therapy

n-Acetylcysteine and Cocaine

Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

Evaluation of Teen Connection Project for Trans and Gender Minority Youth

The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep

Contingency Management for Drug Use: Does Age Matter?

Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users

Effects of Nicotine on Brain Activity as Measured by fMRI