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ClinicalTrials.gov public records Last synced Oct 1, 2026, 9:30 PM EDT

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Showing 25–46 of 46 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Medication for Opioid Use Disorder (MOUD) Clear all

Conditions: Opioid Use Disorder
Interventions: Recovery Community Center Participation, Enhance Treatment as Usual; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid Use Disorder
Interventions: Contingency Management, Usual care as prescribed by the ED physicians; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions: FamilyCHESS, Standard of Care; Behavioral
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 338 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2031
U.S. locations: 2
States / cities: Chicago, Illinois • Madison, Wisconsin

Conditions: Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use, Opioid Use Disorder, Drug Overdose, Overdose Prevention, Co-occurring Mental Health Conditions
Interventions: Practice Companion; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 14 Years to 24 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid-use Disorder
Interventions: imFREE mCBT, mHealth ED; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Tarzana, California

Conditions: Opioid Use Disorder
Interventions: Not listed
Lead sponsor: Indivior Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 480 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 35
States / cities: Costa Mesa, California • Escondido, California • Westport, Connecticut + 31 more

Conditions: Opioid Use Disorder
Interventions: Youth Opioid Recovery Support (YORS); Behavioral
Lead sponsor: Potomac Health Foundations; Other
Eligibility: 13 Years to 21 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Opioid Use Disorder
Interventions: Patient Decision Aid; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 7,554 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
Interventions: MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing); Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Opioid Use Disorder
Interventions: Extended-Release Buprenorphine Injection; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Opiod Use Disorder
Interventions: OUD screening, MOUD, Continuity of care; Other
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 16 Years and older
Enrollment: 271,031 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
Interventions: TRTME; Behavioral
Lead sponsor: T. John Winhusen, PhD; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Opioid Use Disorder, Overdose
Interventions: Pharmacist Narcan Training, BIRT, SMC, Substance Use Counselor Narcan Training; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years and older
Enrollment: 267 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Opioid-use Disorder
Interventions: Moderate Treatment Approach, Intensive Treatment Approach; Other
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid Use Disorder, Digital Health Intervention, Telemedicine, Outreach Intervention
Interventions: emPath Intervention; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Opioid Use Disorder
Interventions: Buprenorphine Extended-Release Injection; Drug
Lead sponsor: Indivior Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023
U.S. locations: 6
States / cities: San Diego, California • Hollywood, Florida • Miami Lakes, Florida + 3 more

Conditions: Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse, Drug Abuse in Pregnancy, Drug Addiction
Interventions: Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control; Behavioral
Lead sponsor: T. John Winhusen, PhD; Other
Eligibility: 18 Years and older · Female only
Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 6
States / cities: Jacksonville, Florida • Pittsburgh, Pennsylvania • Charleston, South Carolina + 3 more

Conditions: Opioid Use
Interventions: Behavioral Activation (BA); Behavioral
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Opioid Use Disorder
Interventions: Not listed
Lead sponsor: Tools4Patient; Other
Eligibility: 18 Years and older
Enrollment: 295 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 2
States / cities: San Diego, California • Vista, California

Conditions: Opioid Abuse (Disorder)
Interventions: Project ECHO; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Substance Use, Substance Use Disorders, Opioid-use Disorder, Peer Delivered, Medication for Opioid Use Disorder (MOUD), Methadone Treatment, Retention in Care, Behavioral Activation
Interventions: Peer-Delivered Behavioral Activation (Peer Activate); Behavioral
Lead sponsor: University of Maryland, College Park; Other
Eligibility: 18 Years and older
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 2
States / cities: Baltimore, Maryland • College Park, Maryland

Conditions: Opioid Use Disorder, Poor Quality Sleep
Interventions: mHealth application and sleep health education, Simplified mHealth application and sleep health education; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

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Towards Testing the Effectiveness of Recovery Community Centers (RCCs)

Contingency Management to Improve Medication for Opioid Use Disorder Continuation After the Emergency Department

Family-Focused Study to Support Medication for Opioid Use Disorder

Clinician Practice Companion to Address Youth Substance Use

Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use

SUBLOCADE Long-term Outcomes

Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD

Patient Decision Aid for Opioid Use Disorder

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

Assessing Optimal XR-Buprenorphine Initiation Points in Jail

Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System

TRTME: Improving Outpatient Initiation of Medication for Opioid Use Disorder Following Hospitalization

Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD)

Response to Relapse in Office-Based Opioid Treatment Trial

Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina

Evaluation of Buprenorphine Extended-Release Subcutaneous Injection at Alternative Injection Locations

Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD

FOREward Together: Training Peer Recovery Coaches to Promote Retention and Adherence to MOUD

Real-World Evaluation of Compl-AI for Predicting Early Medication Dropout in Opioid Use Disorder Treatment

Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes

Peer-Delivered Behavioral Activation for Methadone Adherence - Pilot Phase

Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD