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ClinicalTrials.gov public records Last synced Nov 14, 2026, 8:54 PM EST

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Showing 1–24 of 114 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Menopause Hot Flashes Clear all

Conditions: Sleep Initiation and Maintenance Disorders, Depression
Interventions: Estrogen Replacement Therapy, Zolpidem, placebo; Drug
Lead sponsor: Hadine Joffe, MD; Other
Eligibility: 40 Years to 60 Years · Female only
Enrollment: 86 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Postmenopause
Interventions: 0.25mg DRSP / 0.5mg E2 (BAY86-4891), 0.5mg NETA / 1.0mg E2 (Activella); Drug
Lead sponsor: Bayer; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 662 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 17
States / cities: Chandler, Arizona • San Diego, California • Denver, Colorado + 13 more

Conditions: D008593
Interventions: Shatavari Root Extract, oral capsule; Dietary Supplement
Lead sponsor: Jacksonville University; Other
Eligibility: 40 Years to 60 Years · Female only
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Menopause, Menopause Hot Flashes, Menopause Related Conditions, Cardiovascular
Interventions: Metformin, semaglutide, Anti-hypertensives, Lipid Lowering Medication, Life style intervention, Fezolinetant, Hormonal therapy; Drug · Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 45 Years to 55 Years · Female only
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 3
States / cities: Aurora, Colorado • Chapel Hill, North Carolina • Richmond, Virginia

Conditions: Vasomotor Symptoms Associated With Menopause, Hot Flashes
Interventions: Elinzanetant (BAY3427080), Placebo; Drug
Lead sponsor: Bayer; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 396 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 55
States / cities: Birmingham, Alabama • Mesa, Arizona • Scottsdale, Arizona + 47 more

Conditions: Menopause
Interventions: Ashoka Bark and Shatavari, Placebo; Dietary Supplement · Other
Lead sponsor: Vidya USA Corporation; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New Port Richey, Florida

Conditions: Hot Flashes, Stress
Interventions: Mindfulness-based stress reduction; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 40 Years to 69 Years · Female only
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2012
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Breast Cancer, Hot Flashes
Interventions: informational intervention; Other
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 183 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Vasomotor Symptoms Associated With Menopause
Interventions: Black cohosh, Multibotanical preparation, Multibotanical preparation + dietary soy counseling, Conjugated equine estrogen +/- medroxyprogesterone acetate; Drug
Lead sponsor: Kaiser Permanente; Other
Eligibility: 45 Years to 55 Years · Female only
Enrollment: 351 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2004
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Postmenopause, Hot Flashes, Osteoporosis, Postmenopausal
Interventions: Black Cohosh; Drug
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH); NIH
Eligibility: 45 Years to 70 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2005
U.S. locations: 1
States / cities: New York, New York

Conditions: Menopause, Menopausal Symptoms, Hot Flashes, Night Sweats, Sleep Disturbance, Mood Changes, Fatigue
Interventions: Primal Meno+ Supplement; Dietary Supplement
Lead sponsor: Primal Harvest, LLC; Industry
Eligibility: 40 Years to 60 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Las Vegas, Nevada

Conditions: Menopause, Menopause Related Conditions, Menopause Syndrome
Interventions: Hot water therapy, Warm water immersion; Behavioral
Lead sponsor: University of Colorado, Colorado Springs; Other
Eligibility: 40 Years to 80 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Colorado Springs, Colorado

Conditions: Menopausal Hot Flashes, Menopausal Women
Interventions: ashwagandha root, ashwagandha root and leaf, Placebo; Dietary Supplement · Other
Lead sponsor: Nutraceuticals Research Institute; Other
Eligibility: 40 Years to 55 Years · Female only
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Huntsville, Alabama

Conditions: Vasomotor Symptoms
Interventions: Acupuncture; Procedure
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 45 Years to 60 Years · Female only
Enrollment: 209 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 2
States / cities: Chapel Hill, North Carolina • Winston-Salem, North Carolina

Conditions: Menopausal and Female Climacteric States
Interventions: Other: Placebo, GSK232802, PREMARIN; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 356 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 41
States / cities: Chandler, Arizona • Glendale, Arizona • Scottsdale, Arizona + 35 more

Conditions: Bipolar Disorder, Major Depressive Disorder, Menopause
Interventions: Cognitive Behavioral Group Therapy; Behavioral
Lead sponsor: Danette Conklin, PhD; Other
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Hot Flashes
Interventions: Gabapentin Extended Release, Placebo; Drug
Lead sponsor: Depomed; Industry
Eligibility: 18 Years to 70 Years · Female only
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 66
States / cities: Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 63 more

Conditions: Hot Flushes, Vasomotor Symptoms
Interventions: MF101 5 g/day, Placebo, MF101 10 g/day; Drug
Lead sponsor: Bionovo; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 1,200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2011
U.S. locations: 50
States / cities: Phoenix, Arizona • Tucson, Arizona • Berkeley, California + 44 more

Conditions: Menopause Hot Flashes
Interventions: MT-8554 1mg, MT-8554 5mg, MT-8554 10mg, Placebo; Drug
Lead sponsor: Tanabe Pharma America, Inc.; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 375 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 63
States / cities: Birmingham, Alabama • Dothan, Alabama • Phoenix, Arizona + 50 more

Conditions: Postmenopausal Symptoms
Interventions: Brisdelle (paroxetine mesylate), Placebo capsules; Drug
Lead sponsor: Noven Therapeutics; Industry
Eligibility: 40 Years and older · Female only
Enrollment: 614 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 74
States / cities: Mobile, Alabama • Chandler, Arizona • Glendale, Arizona + 63 more

Conditions: Hot Flashes
Interventions: Brisdelle (paroxetine mesylate), Placebo capsules; Drug
Lead sponsor: Noven Therapeutics; Industry
Eligibility: 40 Years and older · Female only
Enrollment: 570 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 32
States / cities: Montgomery, Alabama • Chandler, Arizona • San Diego, California + 28 more

Conditions: Hot Flashes, Hot Flushes, Vasomotor Symptoms
Interventions: Stellate Ganglion Block Injection with Bupivicaine, Saline injection; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 40 Years to 70 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 2
States / cities: Chicago, Illinois

Conditions: Hot Flashes, Menopause
Interventions: TU 025 Keishi Bukuryo Gan; Drug
Lead sponsor: Plotnikoff, Gregory A., M.D.; Individual
Eligibility: 45 Years to 58 Years · Female only
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Insomnia
Interventions: suvorexant, placebo; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Search by objective public record fields.

Estrogen for Treating Depression in Menopausal Women With Hot Flashes and Insomnia

Endometrial Safety Study

Effect of a Cepham Supplement on Hot Flashes and Menopausal Symptoms in Postmenopausal Women

Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

A Study to Learn More About How Well Elinzanetant Works and How Safe it is for the Treatment of Vasomotor Symptoms (Hot Flashes) That Are Caused by Hormonal Changes Over 26 Weeks in Women Who Have Been Through the Menopause

Satavari and Ashoka for Menopause (SAM) Study

Mindfulness Based Stress Reduction for Hot Flashes

Menopausal Symptoms in Women With Breast Cancer or At High Risk of Breast Cancer Treated on Another Clinical Trial

Herbal Alternatives for Menopause Symptoms (HALT Study)

Effects of Black Cohosh on Menopausal Hot Flashes

A Clinical Trial to Evaluate the Effects of A Supplement on Symptoms of Menopause and Overall Well-being

Hot Water Therapy for the Treatment of Menopause-related Hot Flashes

The Effectiveness of a Proprietary Ashwagandha Extract on Menopausal Symptoms: A Three-Arm Randomized, Double-Blinded, Placebo Controlled Clinical Trial

Acupuncture in Menopause

Treatment Of Hot Flashes/Flushes In Postmenopausal Women (WARM Study)

Cognitive Behavioral Group Therapy for the Management of Menopause Symptoms in Mood Disorders

Breeze3:Study of Gabapentin Extended Release in the Treatment of Vasomotor Symptoms(Hot Flashes)in Postmenopausal Women

A Study of MF101 in Postmenopausal Women

MT-8554 for Reduction of Vasomotor Symptoms in Postmenopausal Women

Efficacy/Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms (VMS)

24-Week Efficacy & Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms

Stellate Ganglion Blockade in Post-Menopausal Women

TU 025 Keishi Bukuryo Gan for Post-menopausal Hot Flash Management

Efficacy of Suvorexant in the Treatment of Hot Flash-associated Insomnia