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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:39 PM EST

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Showing 49–72 of 114 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Menopause Hot Flashes Clear all

Conditions: Hot Flashes
Interventions: Fezolinetant, Paroxetine, Citalopram, Escitalopram, Desvenlafaxine, Venlafaxine, Gabapentin, Clonidine, Pregabalin, Oxybutynin, Any other SSRI/SNRI not already specified, Any other non-hormonal pharmacologic therapy prescribed for the treatment of VMS not included in a category above; Drug
Lead sponsor: Astellas Pharma Global Development, Inc.; Industry
Eligibility: 40 Years to 75 Years · Female only
Enrollment: 999 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 48
States / cities: Birmingham, Alabama • Phoenix, Arizona • Lomita, California + 39 more

Conditions: Menopause
Interventions: Paroxetine, placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 40 Years and older · Female only
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Menopause, Hot Flashes
Interventions: Black Cohosh Extract (BCE); Drug
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH); NIH
Eligibility: Female only
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Hot Flashes
Interventions: Fezolinetant, placebo; Drug
Lead sponsor: Astellas Pharma Global Development, Inc.; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 501 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 65
States / cities: Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 53 more

Conditions: Menopausal Hot Flashes
Interventions: transdermal nitroglycerin, Placebo; Drug
Lead sponsor: Alison Huang, MD; Other
Eligibility: 40 Years to 62 Years · Female only
Enrollment: 141 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 2
States / cities: Oakland, California • San Francisco, California

Conditions: Hot Flashes
Interventions: Paced respiration, Sham comparator: fast shallow breathing; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 218 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Hot Flashes
Interventions: Dr. Tagliaferri's Menopause Formula; Dietary Supplement
Lead sponsor: Herba Buena, Inc; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Hot Flashes, Menopause, Vasomotor System; Labile
Interventions: Sympathoexcitatory stressors, Sodium Nitroprusside, Acetylcholine, Terbutaline, Norepinephrine; Other · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 40 Years to 60 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Hot Flashes, Menopause
Interventions: Cooling mattress pad; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 45 Years to 60 Years · Female only
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Vasomotor Symptoms; Hot Flashes
Interventions: Erenumab, Placebo; Biological · Drug
Lead sponsor: Amgen; Industry
Eligibility: 45 Years to 65 Years · Female only
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 7
States / cities: San Diego, California • Miami, Florida • Winston-Salem, North Carolina + 3 more

Conditions: Menopause, Hot Flashes
Interventions: Soy Phytoestrogen, Estradiol, Medroxyprogesterone Acetate (MPA), Soy Placebo, MPA Placebo; Dietary Supplement · Drug
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Menopause, Hot Flashes
Interventions: Fezolinetant, Placebo; Drug
Lead sponsor: Astellas Pharma Global Development, Inc.; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 356 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 51
States / cities: Anniston, Alabama • Birmingham, Alabama • Phoenix, Arizona + 46 more

Conditions: Menopause Hot Flashes
Interventions: Intervention C (Targeted skin cooling), Intervention B (Ambient cooling), Intervention A (Room temperature); Other
Lead sponsor: SRI International; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Menlo Park, California

Conditions: Hot Flashes, Menopause
Interventions: Cimicifuga racemosa, Trifolium pratense, Black cohosh, Red clover; Drug
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH); NIH
Eligibility: Female only
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2006
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Hot Flashes, Menopause, Vasomotor Disturbance
Interventions: Low-dose 17-ß-estradiol with progesterone taper, Venlafaxine XR, Placebo; Drug
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 40 Years to 62 Years · Female only
Enrollment: 339 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2013
U.S. locations: 4
States / cities: Boston, Massachusetts • Chestnut Hill, Massachusetts • Philadelphia, Pennsylvania + 1 more

Conditions: Depression
Interventions: Omega-3 Fatty Acids; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 40 Years and older · Female only
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Menopause, Prediabetes, Obesity
Interventions: Placebo, conjugated estrogens/bazedoxifene (CE/BZA); Other · Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 50 Years to 60 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Menopause, Multiple Sclerosis
Interventions: Tissue Selective Estrogen Complex, Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 62 Years · Female only
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Hot Flashes, Menopause
Interventions: Sympathetic nerve block with 1% lidocaine 1-2 ml, Superficial subcutaneous injection; Procedure
Lead sponsor: Northwestern University; Other
Eligibility: 30 Years to 65 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2018
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Hot Flashes
Interventions: MF101; Drug
Lead sponsor: Bionovo; Industry
Eligibility: 40 Years to 60 Years · Female only
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 4
States / cities: Birmingham, Alabama • San Francisco, California • Minneapolis, Minnesota + 1 more

Conditions: Hot Flashes
Interventions: PD-0299685; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 40 Years to 70 Years · Female only
Enrollment: 527 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 56
States / cities: Phoenix, Arizona • Tucson, Arizona • Jonesboro, Arkansas + 41 more

Conditions: Vasomotor Symptoms, Menopausal Symptoms
Interventions: Estetrol, Placebo, Progesterone; Drug
Lead sponsor: Estetra; Industry
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 1,570 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 65
States / cities: Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 52 more

Conditions: Hot Flashes, Menopause
Interventions: Omega 3 fatty acid vitamins, Placebo capsules; Dietary Supplement
Lead sponsor: Christiana Care Health Services; Other
Eligibility: Up to 65 Years · Female only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Vasomotor Symptoms, Hot Flashes, Menopause
Interventions: HIRREM, Continued Current Care; Device · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 40 Years and older · Female only
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Search by objective public record fields.

A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats

Study of Paxil Use in Menopausal Women

Black Cohosh Extract in Postmenopausal Breast Health

A Study to Find Out if Fezolinetant Helps Reduce Moderate to Severe Hot Flashes in Women Going Through Menopause - 2

Flushing Reduction Associated With Nitrates

Breathe for Hot Flashes Randomized Controlled Trial

Safety and Efficacy of Dr. Tagliaferri's Menopause Formula

Hot Flashes and Neurovascular Function in Women

Reducing the Experience of Menopausal Symptoms Through Temperature

Study of Erenumab (AMG 334) in Women With Hot Flashes

Research Investigation of Soy and Estrogen

A Dose-ranging Study of the Efficacy of ESN364 in Postmenopausal Women Suffering Vasomotor Symptoms (Hot Flashes)

Thermoregulatory Physiology of Menopausal Hot Flashes

Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms

MsFLASH-03: Comparative Efficacy of Low-Dose Estradiol and Venlafaxine XR for Treatment of Menopausal Symptoms

Omega-3 for Peri- and Postmenopausal Depression

Effects of Novel Estrogens on Glucose and Lipids in Postmenopausal Prediabetic Women Veterans

A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis

Pilot Study of Stellate Ganglion Injection to Provide Relief From Hot Flushes

Clinical Trial Assessing Toxicity and Efficacy of MF101 for Hot Flashes

Study Evaluating PD-0299685 for the Treatment of Vasomotor Symptoms (Hot Flashes / Flushes) Associated With Menopause

Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)

Investigation of the Usefulness of Omega 3 Vitamins in the Relief of Hot Flashes in Menopausal Women.

HIRREM Hot Flashes Study