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ClinicalTrials.gov public records Last synced Oct 19, 2026, 7:09 PM EDT

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Showing 433–456 of 1,861 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mental Disorders, Severe Clear all
Completed No phase listed Observational Accepts healthy volunteers

Neuronal Responses to Social Feedback in Major Depressive Disorder

NCT02180607
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 55 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 28, 2015 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Phase 3 Interventional

A Study to Assess the Safety and Efficacy of Oral LPCN 1154A in Women With Severe PPD

NCT06979544
View directory record Official record
Conditions
Depression, Postpartum, Depression, Post-Partum, Postpartum Depression (PPD), Post-Natal Depression, Peripartum Depression, Postnatal Depression
Interventions
LPCN 1154A, Placebo
Drug
Lead sponsor
Lipocine Inc.
Industry
Eligibility
15 Years to 45 Years · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
18
States / cities
Anahiem, California • Canoga Park, California • Miami, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Not applicable Interventional

Pharmacogenetic Testing in an Outpatient Population of Patients With Depression

NCT02497027
View directory record Official record
Conditions
Depression
Interventions
pharmacogenetic testing
Other
Lead sponsor
Avera McKennan Hospital & University Health Center
Other
Eligibility
18 Years and older
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Not applicable Interventional

Testing a Novel Community-based Occupational Therapy Model

NCT03855761
View directory record Official record
Conditions
Mental Disorders, Severe
Interventions
Occupational Therapy, Case management; psychological services
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Oct 19, 2026, 7:09 PM EDT
Completed No phase listed Observational Results available

Adolescents' Well-being in Community-based Treatment Versus Residential Treatment

NCT06498427
View directory record Official record
Conditions
Adolescent Well-Being, Mental Disorders, Severe
Interventions
Not listed
Lead sponsor
Outcome Referrals, Inc.
Industry
Eligibility
12 Years to 18 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Framingham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Not applicable Interventional Results available

Psychosis: Early Detection, Intervention and Prevention

NCT01597141
View directory record Official record
Conditions
Prodromal Schizophrenia, Psychotic Disorders, Severe Bipolar Disorder With Psychotic Features, Severe Major Depression With Psychotic Features
Interventions
Family-aided Assertive Community Treatment, Enhanced standard treatment
Behavioral
Lead sponsor
MaineHealth
Other
Eligibility
12 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2014
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Feb 8, 2016 · Synced Oct 19, 2026, 7:09 PM EDT
Terminated Phase 2Phase 3 Interventional

The Effects of SAINT® Neuromodulation System on Explicit and Implicit Suicidal Cognition

NCT03693105
View directory record Official record
Conditions
Major Depressive Disorder, Major Depressive Episode, Suicidal Ideation
Interventions
Active SAINT Stimulation, Sham SAINT Stimulation
Device
Lead sponsor
Magnus Medical
Industry
Eligibility
18 Years to 75 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
4
States / cities
Iowa City, Iowa • Manhattan, New York • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Phase 2 Interventional

A Trial of the Safety and Efficacy of SEP-363856 in the Treatment of Adults With Major Depressive Disorder

NCT05593029
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
SEP-363856, Placebo
Drug · Other
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
929 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
53
States / cities
Birmingham, Alabama • Scottsdale, Arizona • Tucson, Arizona + 45 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Not applicable Interventional

An Integrated Approach to Smoking Cessation in Severe Mental Illness (SMI)

NCT00690131
View directory record Official record
Conditions
Smoking Cessation
Interventions
BTSCS
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 75 Years
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
3
States / cities
Baltimore, Maryland • Timonium, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Oct 19, 2026, 7:09 PM EDT
Recruiting Not applicable Interventional

Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality

NCT05925322
View directory record Official record
Conditions
Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
Interventions
"Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP)
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
50 Years to 80 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Phase 1 Interventional

A Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depressive Disorder

NCT03374475
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
JNJ-42847922 20mg, JNJ-42847922 40mg, Placebo
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
San Diego, California • San Marcos, California • Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 19, 2026, 7:09 PM EDT
Terminated Phase 3 Interventional Results available

Efficacy and Safety of Brexpiprazole as Adjunctive Treatment in Elderly Patients With Major Depressive Disorder With an Inadequate Response to Antidepressant Treatment

NCT01837797
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Placebo, Brexpiprazole 1 mg, Brexpiprazole 3 mg
Drug
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
65 Years and older
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
2
States / cities
National City, California • Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Oct 19, 2026, 7:09 PM EDT
Recruiting Phase 2 Interventional

Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism

NCT07091279
View directory record Official record
Conditions
Autism Spectrum Disorder, Challenging Behaviour, Aggression, Severe Disruptive Behaviour Disorders, Self-injury
Interventions
Propranolol, Placebo
Drug
Lead sponsor
Jeremy Veenstra-vanderweele
Other
Eligibility
12 Years to 40 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Staten Island, New York • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Phase 2 Interventional Results available

Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD

NCT03051256
View directory record Official record
Conditions
Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant
Interventions
REL-1017, Placebo
Drug
Lead sponsor
Relmada Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
10
States / cities
Little Rock, Arkansas • Garden Grove, California • San Diego, California + 7 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Oct 19, 2026, 7:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia

NCT06493825
View directory record Official record
Conditions
Tinnitus, Misophonia
Interventions
Aurora Mindfulness app versus sham
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
10 Years to 18 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Oct 19, 2026, 7:09 PM EDT
Active, not recruiting Not applicable Interventional

Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder

NCT06670040
View directory record Official record
Conditions
ASD, Autism Spectrum Disorder, Autism, Depression - Major Depressive Disorder, MDD
Interventions
Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham
Procedure
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
13 Years to 26 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Not applicable Interventional

Improving Representative Payeeship for People With Psychiatric Disabilities and Their Families

NCT00924976
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Major Depressive Disorder
Interventions
Steps for Achieving Financial Empowerment (SAFE)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 15, 2018 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Phase 4 Interventional

A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care

NCT00939250
View directory record Official record
Conditions
Type 2 Diabetes, Major Depressive Disorder
Interventions
Diabetes and depression intervention, Diabetes intervention
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 2, 2020 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Not applicable Interventional

Evaluation of the Brainsway Deep Transcranial Magnetic Stimulation (TMS) H-Coil in the Treatment of Major Depression Disorder

NCT00927173
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Brainsway H-Coil Deep TMS System, Brainsway H-Coil Deep TMS System (Sham treatment)
Device
Lead sponsor
Brainsway
Industry
Eligibility
22 Years to 68 Years
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
14
States / cities
Los Angeles, California • Sacramento and Davis, California • Santa Monica, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Oct 19, 2026, 7:09 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Adjunctive Pregnenolone in Post-Traumatic Stress Disorder (PTSD) and Depression in Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans

NCT00993629
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Major Depressive Disorder
Interventions
pregnenolone, placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 27, 2014 · Synced Oct 19, 2026, 7:09 PM EDT
Completed No phase listed Observational

Genetic Study of Liver Enzymes in Patients With Side Effects From Antidepressants

NCT00360256
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 65 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2012 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Not applicable Interventional

Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

NCT00108407
View directory record Official record
Conditions
Alcohol Abuse, Cannabis Abuse, Major Depressive Disorder, Substance-Related Disorders
Interventions
Integrated Cognitive Behavioral Therapy, Twelve Step Facilitation Therapy
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2009 · Synced Oct 19, 2026, 7:09 PM EDT
Completed Not applicable Interventional

A Clinical Trial for the Treatment of Depression With Repetitive Transcranial Magnetic Stimulation (rTMS)

NCT01909232
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Active Cervel Neurotech Multi-Coil Transcranial Magnetic Stimulator, Inactive Cervel Neurotech Multi-Coil Transcranial Magnetic Stimulator
Device
Lead sponsor
Cervel Neurotech, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
6
States / cities
Atlanta, Georgia • Baltimore, Maryland • Lebanon, New Hampshire + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2016 · Synced Oct 19, 2026, 7:09 PM EDT
Withdrawn Phase 2 Interventional

rTMS for Adolescents and Young Adults

NCT00984087
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
TMS with Neurostar TMS Therapy System
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
15 Years to 24 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 19, 2026, 7:09 PM EDT