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ClinicalTrials.gov public records Last synced Oct 18, 2026, 8:25 PM EDT

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Showing 97–120 of 749 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mental Health (Depression) Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of COMET on Prolific Participants

NCT05379881
View directory record Official record
Conditions
Depression, Anxiety, Emotion Regulation
Interventions
Common Elements Toolbox (COMET)
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
829 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 24, 2022 · Synced Oct 18, 2026, 8:25 PM EDT
Recruiting Not applicable Interventional

Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

NCT07227337
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Depression, Violence
Interventions
BSHAPE, Control (general wellness)
Behavioral · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Female only
Enrollment
676 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Addressing Mental Health of Cancer Patients and Caregivers Using a Mobile App Suite

NCT03488745
View directory record Official record
Conditions
Mental Health Wellness 1, Depression, Anxiety
Interventions
IntelliCare + Phone Coaching
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 18, 2026, 8:25 PM EDT
Recruiting Phase 4 Interventional

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

NCT06903819
View directory record Official record
Conditions
Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use, Depression, Post-traumatic Stress Disorder (PTSD)
Interventions
Ketamine, standard general anesthesia
Drug
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Recruiting Not applicable Interventional

Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students

NCT07240792
View directory record Official record
Conditions
Depression, Anxiety, Stress
Interventions
Student Delivered Cognitive Behavioral Therapy Intervention
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
13 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Not listed Not applicable Interventional

Cranial Electrotherapy Stimulation (CES) for Soldiers With Combat-Related Symptoms

NCT00866411
View directory record Official record
Conditions
Combat Related Symptoms, Irritability, Anger
Interventions
cranial electrotherapy stimulation (CES) with Alpha-Stim, placebo
Procedure
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
2
States / cities
Fort Hood, Texas • Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 20, 2009 · Synced Oct 18, 2026, 8:25 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

The Covid-19 HEalth caRe wOrkErS (HEROES) Study

NCT04352634
View directory record Official record
Conditions
Covid-19, Mental Health Disorder, Stress Disorder, Anxiety, Depression, SARS-CoV-2
Interventions
Exposure to the SARS-CoV-2 and its consequences
Other
Lead sponsor
University of Chile
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 18, 2026, 8:25 PM EDT
Completed Not applicable Interventional Results available

Positive Processes and Transition to Health

NCT04678232
View directory record Official record
Conditions
Major Depressive Disorder, Post Traumatic Stress Disorder
Interventions
Positive Processes and Transition to Health (PATH)
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Newark, Delaware • Cleveland, Ohio • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Oct 18, 2026, 8:25 PM EDT
Enrolling by invitation Not applicable Interventional

Impact of Exercise Groups on Patient Mental Health and Wellbeing in an Acute Psychiatric Inpatient Unit

NCT05859204
View directory record Official record
Conditions
Psychiatric Hospitalization, Physical Inactivity, Depression, Anxiety, Sleep
Interventions
OT-led Exercise Group, Treatment as Usual - OT Groups
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Enrolling by invitation No phase listed Observational

Assess the Utility of a Speech-based Machine Learning Algorithm to Predict Treatment Response to Psychiatric Interventions

NCT06823024
View directory record Official record
Conditions
Obsessive Compulsive Disorder (OCD), Bipolar Disorders, Major Depressive Disorder, Post-Traumatic Stress Disorder, PTSD, Generalized Anxiety Disorder (GAD)
Interventions
Not listed
Lead sponsor
Psyrin Inc.
Industry
Eligibility
18 Years to 68 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Sunnyvale, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 18, 2026, 8:25 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Does Social Media Impact Adolescent Mental Health?

NCT06049888
View directory record Official record
Conditions
Mental Health
Interventions
Restricted Social Media
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
10 Years to 14 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Recruiting Not applicable Interventional

Deconstructing Maternal Burdens: Doulas and the Community Unite for Health

NCT07799805
View directory record Official record
Conditions
Pregnancy, Post Partum, Doula Care, Postpartum Depression (PPD), Perinatal Depression, Perinatal Anxiety, Health Disparities, Pregnancy Complications, Maternal Adverse Outcomes
Interventions
Doula, Standard (non-enhanced) Medicaid doula support
Other
Lead sponsor
University of Florida
Other
Eligibility
15 Years to 49 Years · Female only
Enrollment
516 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Terminated Not applicable Interventional Results available

Improving Mental Health Outcomes: Building an Adaptive Implementation Strategy

NCT02151331
View directory record Official record
Conditions
Bipolar Disorder, Depression, Mood Disorder
Interventions
External Facilitation, External + Internal Facilitation
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 99 Years
Enrollment
383 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Denver, Colorado • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Oct 18, 2026, 8:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Healing Lodge First Face Training Evaluation Study

NCT06290180
View directory record Official record
Conditions
Addiction, Depression/Anxiety, Trauma, Psychological, Self-harm
Interventions
First Face for Mental Heatlh
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
Not listed
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Spokane Valley, Washington
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 18, 2026, 8:25 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Effectiveness of the Adapt for Life, Mental Wellness and Suicide Prevention Program

NCT06979479
View directory record Official record
Conditions
Depression Disorders, Suicidality
Interventions
school-based intervention
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Not listed
Enrollment
1,102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Oct 18, 2026, 8:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Promoting Maternal Mental Health and Wellbeing in Neonatal Intensive Care

NCT03942627
View directory record Official record
Conditions
Depressive Symptoms, Anxiety, Post-traumatic Stress Symptoms
Interventions
Mindfulness Program, Infant Health Education Program
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 27, 2021 · Synced Oct 18, 2026, 8:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Optimizing Mental Health in Orthopedic Care

NCT05194722
View directory record Official record
Conditions
Anxiety, Depression, Back Pain, Neck Pain
Interventions
Wysa mobile app
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Understanding the Role of Doulas in Supporting People With PMADs

NCT05763537
View directory record Official record
Conditions
Maternal Health, Pregnancy, Delivery, Obstetric, Self Efficacy, Social Support, Mental Health, Substance-Related Disorders, Postpartum Depression, Depression, Mental Health Services
Interventions
Standard Doula Care Plus PMAD Intervention, Standard Doula Care
Behavioral
Lead sponsor
University of Montana
Other
Eligibility
18 Years and older · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Active, not recruiting Not applicable Interventional

AI Mental Health Tool vs. Psychoeducation Control

NCT07841483
View directory record Official record
Conditions
Depressive Disorder, Depressive Symptoms
Interventions
Ash, Brief Therapist-Delivered Telehealth
Behavioral
Lead sponsor
Slingshot AI
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Recruiting Not applicable Interventional

Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial

NCT07223736
View directory record Official record
Conditions
Pelvic Floor Disorder, Loneliness, Postpartum, Mental Health, Depression, Peritraumatic Distress, Women, Artificial Intelligence (AI), Chatbot
Interventions
Generative artificial intelligence (genAI) postpartum chatbot, Standard of Care (SOC)
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Oct 18, 2026, 8:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

How Body Awareness Promotes Mental Health During Yoga and Physical Exercise

NCT03553745
View directory record Official record
Conditions
Negative Thoughts, Mild Depression, Stress
Interventions
Gentle Yoga Intervention, Rigorous Yoga Intervention, Physical Exercise Intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2021 · Synced Oct 18, 2026, 8:25 PM EDT
Completed Not applicable Interventional

Supporting Our Valued Adolescents Pilot Randomized Controlled Trial

NCT03318666
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Supporting Our Valued Adolescents (SOVA), Enhanced Usual Care
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 19 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 26, 2021 · Synced Oct 18, 2026, 8:25 PM EDT
Recruiting Not applicable Interventional

Brief Smartphone Treatment Study

NCT04846777
View directory record Official record
Conditions
Generalized Anxiety Disorder
Interventions
Mindfulness ecological momentary intervention, Self-monitoring placebo
Device
Lead sponsor
Penn State University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Oct 18, 2026, 8:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

FASTLANE II: Reducing Sex, Drug, and Mental Health Risk

NCT04109014
View directory record Official record
Conditions
Methamphetamine Abuse, HIV/AIDS, Depression, Sex, Unsafe
Interventions
FASTLANE II
Other
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Oct 18, 2026, 8:25 PM EDT