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ClinicalTrials.gov public records Last synced Oct 11, 2026, 10:37 AM EDT

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Showing 121–144 of 1,366 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mental Health Impairment Clear all
Recruiting Phase 3 Interventional Accepts healthy volunteers

Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease

NCT06254469
View directory record Official record
Conditions
Alzheimer Disease, Chronic Traumatic Encephalopathy
Interventions
[F-18]Flornaptitril
Drug
Lead sponsor
CereMark Pharma, LLC
Industry
Eligibility
45 Years and older
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Oct 11, 2026, 10:37 AM EDT
Not listed Not applicable Interventional

Electronic Memory and Management Aid

NCT05696756
View directory record Official record
Conditions
Subjective Cognitive Complaints, Mild Cognitive Impairment
Interventions
Personalized Web-based training for EMMA app, Motivational Interviewing: Clinician Support
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pullman, Washington
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 11, 2026, 10:37 AM EDT
Enrolling by invitation Not applicable Interventional

Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability

NCT02914951
View directory record Official record
Conditions
Autism, Intellectual Disability
Interventions
Cognitive-Behavioral Therapy, Functional magnetic resonance imaging (fMRI)
Behavioral · Other
Lead sponsor
Yale University
Other
Eligibility
8 Years to 16 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 11, 2026, 10:37 AM EDT
Not listed Phase 2 Interventional

Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder

NCT01466205
View directory record Official record
Conditions
Cognitive Impairments, Schizotypal Personality Disorder
Interventions
DAR-0100A, Placebo
Drug
Lead sponsor
Larry J. Siever
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 20, 2012 · Synced Oct 11, 2026, 10:37 AM EDT
Active, not recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Metformin in Alzheimer's Dementia Prevention

NCT04098666
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Placebo oral tablet, extended release metformin
Drug
Lead sponsor
Columbia University
Other
Eligibility
55 Years to 90 Years
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
22
States / cities
Irvine, California • Palo Alto, California • Washington D.C., District of Columbia + 17 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Phase 2 Interventional

Prostate Cancer Survivors and Exercise and Behavioral Counseling

NCT03191968
View directory record Official record
Conditions
Physical Activity, Cancer of the Prostate, Cognitive Impairment, Quality of Life
Interventions
Supervised Physical Activity Plus Behavioral Counseling, Supervised Physical Activity Plus Exercise Counseling
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 80 Years · Male only
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 20, 2019 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the CG ASSIST Program for Caregiving Dyads

NCT02021565
View directory record Official record
Conditions
Transfer Impairment
Interventions
Immediate Intervention Group, Delayed Intervention Control Group
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Mar 1, 2018 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders

NCT01333098
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Mifepristone
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
60 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Not applicable Interventional Results available

Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment

NCT01983930
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Kundalini yoga and meditation, Memory Training
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
55 Years to 90 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 11, 2026, 10:37 AM EDT
Not listed Phase 4 Interventional

Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment:Pilot Study

NCT02190019
View directory record Official record
Conditions
Apathy, Mild Cognitive Impairment
Interventions
Neurostar repetitive transcranial magnetic stimulator
Device
Lead sponsor
Central Arkansas Veterans Healthcare System
Federal
Eligibility
55 Years to 91 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2016 · Synced Oct 11, 2026, 10:37 AM EDT
Terminated Phase 1 Interventional

Study of the Pharmacokinetics and Pharmacodynamics of POSIPHEN® in Subjects With Amnestic Mild Cognitive Impairment

NCT01072812
View directory record Official record
Conditions
Alzheimer's Disease, Amnestic Mild Cognitive Impairment
Interventions
Posiphen® tartrate capsules
Drug
Lead sponsor
Annovis Bio Inc.
Industry
Eligibility
55 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 22, 2015 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety, Tolerability and Efficacy Study to Evaluate Subjects With Mild Cognitive Impairment

NCT00422981
View directory record Official record
Conditions
Mild Cognitive Impairment, So Stated
Interventions
AL-108, Placebo
Drug
Lead sponsor
Allon Therapeutics
Industry
Eligibility
55 Years to 85 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
17
States / cities
Peoria, Arizona • Garden Grove, California • National City, California + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2012 · Synced Oct 11, 2026, 10:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

COcoa Supplement and Multivitamin Outcomes Study for the Mind

NCT03035201
View directory record Official record
Conditions
Cognitive Impairment, Dementia, Aging
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Enrollment
2,262 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Oct 11, 2026, 10:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Alzheimer's Disease Neuroimaging Initiative Grand Opportunity

NCT01078636
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
Not listed
Lead sponsor
Alzheimer's Disease Cooperative Study (ADCS)
Other
Eligibility
55 Years to 90 Years
Enrollment
342 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
50
States / cities
Birmingham, Alabama • Phoenix, Arizona • Sun City, Arizona + 39 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2014 · Synced Oct 11, 2026, 10:37 AM EDT
Recruiting Not applicable Interventional

Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)

NCT06736444
View directory record Official record
Conditions
Insomnia, Alcohol Use, Marijuana Use
Interventions
Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS), Attention Control
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 29 Years
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 11, 2026, 10:37 AM EDT
Not listed Not applicable Interventional

Sleep-directed Hypnosis As A Complement To Cognitive Processing Therapy (CPT) In Treating Posttraumatic Stress Disorder (PTSD)

NCT00725192
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive Processing Therapy, Hypnosis
Behavioral
Lead sponsor
Center for Trauma Recovery, St Louis
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 7, 2011 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Phase 2 Interventional

Impact of Grape Consumption on Brain Metabolism and Neuropsychological Performance Over 1 Year

NCT03361410
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Grape Powder, Placebo Powder
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
65 Years to 85 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Not applicable Interventional Results available

SHARE: Sharing Healthcare Wishes in Primary Care

NCT04593472
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Sharing Healthcare Wishes in Primary Care (SHARE), Minimally Enhanced Usual Care
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
80 Years and older
Enrollment
273 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
9
States / cities
Baltimore, Maryland • Dundalk, Maryland • Mitchellville, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Not applicable Interventional

ABC Trial: Awakening and Breathing Controlled

NCT00097630
View directory record Official record
Conditions
Aging, Respiration, Artificial
Interventions
SAT: Spontaneous Awakening Trial, SBT: Spontaneous Breathing Trial
Procedure
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years and older
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
4
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 11, 2009 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Age-related Correlates of Treatment for Late-acquired Sounds

NCT03663972
View directory record Official record
Conditions
Speech Sound Disorder, Phonology Disorder, Phonology Impairment, Phonological Disorder, Articulation Disorders in Children, Developmental Phonological Disorder, Speech Disorders, Speech Delay, Articulation Disorders, Developmental
Interventions
articulation therapy, phonologic treatment
Behavioral
Lead sponsor
University of Wyoming
Other
Eligibility
4 Years to 8 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Laramie, Wyoming
Source: ClinicalTrials.gov public record
Updated Jun 18, 2020 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Practice Effects and Amyloid Imaging Using 18F-PIB or Flutemetamol PET and FDG-PET

NCT01202994
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
18F-Flutemetamol
Drug
Lead sponsor
University of Utah
Other
Eligibility
65 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Oct 11, 2026, 10:37 AM EDT
Not yet recruiting Phase 2 Interventional

Restoring Vascular and Insulin Function To Augment Anti-Amyloid Therapy in Alzheimer's Disease

NCT07756294
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Empagliflozin, Insulin, Insulin Placebo, Empagliflozin Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
55 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Asynchronous Techniques for the Delivery of Empirically Supported Psychotherapies

NCT05122429
View directory record Official record
Conditions
Depressive Symptoms, Anxiety, Stress, Impairment
Interventions
e-Health Treatment
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Nov 16, 2021 · Synced Oct 11, 2026, 10:37 AM EDT
Completed Phase 1 Interventional

Home Care Medication Management Program for the Frail Elderly

NCT01321853
View directory record Official record
Conditions
Chronic Illness, Cognitive Impairment
Interventions
MD2 machine and nurse care coordination, Medplanner and Nurse Care Coordination
Other
Lead sponsor
Arizona State University
Other
Eligibility
60 Years and older
Enrollment
414 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 6, 2012 · Synced Oct 11, 2026, 10:37 AM EDT