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Showing 1–24 of 25 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Metabolic Flexibility Clear all
Completed Phase 3 Interventional Results available

Comparison of NN1250 With Insulin Glargine in Type 1 Diabetes

NCT01079234
View directory record Official record
Conditions
Diabetes, Diabetes Mellitus, Type 1
Interventions
insulin degludec, insulin glargine, insulin aspart
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
493 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
40
States / cities
Encino, California • Fresno, California • Huntington Beach, California + 34 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fuel Utilization, Diet Composition, and Exercise in African American Women

NCT04293367
View directory record Official record
Conditions
Obesity, Diabetes, Insulin Resistance
Interventions
High Intensity Interval Training (HIIT)
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
20 Years to 40 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2020 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber

NCT03839641
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
High fat meal, Low fat meal
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 40 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Jun 10, 2026, 9:58 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans

NCT04293224
View directory record Official record
Conditions
Obesity, Body Weight
Interventions
DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
19 Years to 64 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Jun 10, 2026, 9:58 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Metabolic Adaptations to High-fat Diet

NCT06537401
View directory record Official record
Conditions
Adiposity, Insulin Sensitivity, Impaired Glucose Tolerance, Metabolic Disturbance
Interventions
Hypercaloric, High Fat Diet
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
20 Years to 45 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Validating a Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber

NCT05110274
View directory record Official record
Conditions
Metabolism
Interventions
Overnight Metabolic Flexibility, Clamp Metabolic Flexibility
Procedure
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 40 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 8, 2023 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional

Cocoa and Metabolic Health in Prediabetes

NCT02203240
View directory record Official record
Conditions
Prediabetes
Interventions
Cocoa, Placebo
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Jun 10, 2026, 9:58 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Diet-Induced Changes in GEnetic Material

NCT06252922
View directory record Official record
Conditions
Diet, Healthy, Body Weight, Metabolic Disturbance
Interventions
Not listed
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
20 Years to 35 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional

Unsaturated Fatty Acids Enriched-diet to Improve Cardiorespiratory Fitness, Metabolic Flexibility and Glucose Tolerance in Obese Patients

NCT03310099
View directory record Official record
Conditions
Heart Failure With Normal Ejection Fraction, Obesity
Interventions
Increasing daily unsaturated fatty acid consumption
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Breaking up Prolonged Sitting on Metabolic Flexibility

NCT02258438
View directory record Official record
Conditions
Health Behavior
Interventions
Uninterrupted sitting, Sitting + 1 bout of activity, Sitting + microbursts of activity
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
19 Years to 45 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 29, 2021 · Synced Jun 10, 2026, 9:58 AM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism

NCT07218497
View directory record Official record
Conditions
Cognition, BDNF
Interventions
d-beta-hydroxybutrate, Placebo
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 35 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Astaxanthin Reduces Exercising Heart Rate.

NCT05282355
View directory record Official record
Conditions
Metabolic Flexibility
Interventions
Astaxanthin, Placebo
Dietary Supplement
Lead sponsor
University of North Alabama
Other
Eligibility
18 Years to 45 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Florence, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

This Study Assessed the Impact of Diet on Gastric Emptying Time and Metabolic Flexibility

NCT03630263
View directory record Official record
Conditions
Obesity, Diabetes Mellitus, Type 2, Appetitive Behavior
Interventions
Raw Corn Starch, No Raw Corn Starch
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 15, 2022 · Synced Jun 10, 2026, 9:58 AM EDT
Terminated Not applicable Interventional

Exercise Training and Metabolic Flexibility in Prediabetes

NCT04051229
View directory record Official record
Conditions
PreDiabetes, Sedentary Lifestyle
Interventions
6-week exercise training program, Standardized isoenergetic high fat diet
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 6, 2023 · Synced Jun 10, 2026, 9:58 AM EDT
Recruiting Not applicable Interventional

Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

NCT05540704
View directory record Official record
Conditions
Type 1 Diabetes, Eating Disorders, Disordered Eating Behaviors, Purging (Eating Disorders), Binge-Eating Disorder
Interventions
ACT, Supportive Diabetes Counseling
Behavioral
Lead sponsor
Duke University
Other
Eligibility
16 Years to 50 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Durham, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional

Prebiotics, Gut Microbiota, and Cardiometabolic Health

NCT02346838
View directory record Official record
Conditions
Prediabetes
Interventions
Inulin, Placebo
Dietary Supplement
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years to 70 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Muscle Energy Metabolism and Metabolic Flexibility in Older Men and Women

NCT03701867
View directory record Official record
Conditions
Energy Metabolism
Interventions
Metabolic Flexibility Tests
Other
Lead sponsor
Abbott Nutrition
Industry
Eligibility
65 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Metabolic Flexibility as a Biomarker of Adaptation to Diet and Exercise Challenges

NCT01987388
View directory record Official record
Conditions
Healthy Volunteers
Interventions
High Intensity Exercise, Low Intensity Exercise, High Carbohydrate Beverage, High Fat Beverage
Other
Lead sponsor
USDA Beltsville Human Nutrition Research Center
Federal
Eligibility
22 Years to 35 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Jun 10, 2026, 9:58 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants

NCT07096011
View directory record Official record
Conditions
Infant Body Composition and Metabolism, Metabolism, Energy Expenditure, Infant Formula, Human Milk, Breast Milk, Metabolic Flexibility
Interventions
Meal Test - Human Milk, Meal Test - Infant Formula
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
2 Weeks to 16 Weeks
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jun 10, 2026, 9:58 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pistachio Snacking and Metabolic Flexibility

NCT07340125
View directory record Official record
Conditions
Overweight (BMI > 25), Obese But Otherwise Healthy Participants, Overweight or Obese, Obese Patients (BMI ≥ 30 kg/m²), Poor Sleep Quality, Healthy Participants, Physically Inactive
Interventions
Pistachio
Other
Lead sponsor
University of South Carolina
Other
Eligibility
25 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MitoQ & Cardiopulmonary Responses During Exercise

NCT06069245
View directory record Official record
Conditions
Healthy
Interventions
MitoQ, Placebo
Dietary Supplement
Lead sponsor
Ball State University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 4, 2023 · Synced Jun 10, 2026, 9:58 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Impact of Metabolic Flexibility on Changes in Metabolic Health

NCT06340321
View directory record Official record
Conditions
Obesity, Metabolic Syndrome
Interventions
Metabolic flexibility in the fasted state, Metabolic flexibility in euglycemic-hyperinsulinemic clamp, Metabolic flexibility in the metabolic chamber
Diagnostic Test · Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
20 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Jun 10, 2026, 9:58 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks

NCT05820490
View directory record Official record
Conditions
Metabolic Health
Interventions
Whole Room Calorimeter, Mixed-Meal Tolerance Test (MMTT), Core Body Temperature, Morningness-Eveningness Questionnaire, Muscle Biopsy, Serial Blood Sampling
Other · Procedure
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jun 10, 2026, 9:58 AM EDT
Completed Not applicable Interventional

Acceptance and Commitment Therapy Principles for Diabetes Prevention

NCT05260983
View directory record Official record
Conditions
PreDiabetes, Diabetes Mellitus, Type 2, Diabetes, Diabetes type2
Interventions
Diabetes Prevention Education and Acceptance and Commitment Therapy, Diabetes Prevention Education Only
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Jun 10, 2026, 9:58 AM EDT