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ClinicalTrials.gov public records Last synced Oct 29, 2026, 8:14 AM EDT

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Showing 1105–1128 of 1,516 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Metabolism Changes Clear all
Recruiting Phase 2 Interventional

Incretin Microdosing for Cardiometabolic Health in People With HIV

NCT07325500
View directory record Official record
Conditions
Weight Gain
Interventions
Dose escalation to 2 mg semaglutide weekly then semaglutide microdosing at 0.5 mg weekly, Dose escalation to 2 mg semaglutide weekly then no semaglutide
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Weight Loss-Independent Metabolic Effects of Roux-En-Y Gastric Bypass in Diabetes

NCT02207777
View directory record Official record
Conditions
Obesity, Type 2 Diabetes
Interventions
Roux-en-Y gastric bypass surgery, Low-calorie diet
Procedure · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
25 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhanced DPP-GLB to Promote Weight Loss Among Nonresponders in a Community-Based Lifestyle Intervention.

NCT04757519
View directory record Official record
Conditions
Diabetes
Interventions
DPP-GLB Standard, DPP-GLB Enhanced
Behavioral
Lead sponsor
Lovoria Williams
Other
Eligibility
18 Years and older
Enrollment
403 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
21
States / cities
Frankfort, Kentucky • Lexington, Kentucky • Louisville, Kentucky + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 29, 2026, 8:14 AM EDT
Recruiting Phase 2 Interventional

2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)

NCT04941599
View directory record Official record
Conditions
Familial Hypercholesterolemia
Interventions
2-Hydroxybenzylamine, Placebo
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 69 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Multi-Center Study Comparing Efficacy and Safety of Frequently Modified Insulin Therapy

NCT02424500
View directory record Official record
Conditions
Diabetes Mellitus, Type 2, Hypoglycemia
Interventions
d-Nav, Blood Glucose Monitoring System
Device
Lead sponsor
Hygieia Research LLC
Other
Eligibility
21 Years to 70 Years
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Glycemic Load, Metabolism & Obesity in Pregnancy

NCT01287299
View directory record Official record
Conditions
Obesity, Insulin Resistance
Interventions
Low Glycemic Load diet, Low Fat Diet
Other
Lead sponsor
UCSF Benioff Children's Hospital Oakland
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 24, 2020 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury

NCT04530032
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
ketogenic/modified Atkins diet, Standard diet
Other
Lead sponsor
Loma Linda University
Other
Eligibility
16 Years to 90 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Diltiazem Administration on CP-945,598 Pharmacokinetics

NCT00645463
View directory record Official record
Conditions
Obesity
Interventions
CP-945,598
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 17, 2009 · Synced Oct 29, 2026, 8:14 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Predictors of Maternal Weight Gain and Neonatal Body Composition

NCT00634764
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2018 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lay Health Coaches for Weight Loss: Peers Versus Mentors

NCT01642199
View directory record Official record
Conditions
Obesity
Interventions
Reduced Intensity Behavioral Weight Loss + Peer Health Coach, Reduced Intensity Behavioral Weight Loss + Mentor Health Coach, Reduced Intensity Behavioral Weight Loss
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
40 Years to 60 Years
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 3, 2019 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Soy Protein and Colorado Diet on Weight Loss and Maintenance

NCT02380963
View directory record Official record
Conditions
Overweight, Obesity, Weight Loss
Interventions
Colorado Diet with soy protein foods., Colorado Diet with monetary payments
Dietary Supplement · Behavioral
Lead sponsor
DuPont Nutrition and Health
Industry
Eligibility
18 Years to 55 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 4, 2019 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Phase 2 Interventional

Text to Move (TTM)Study

NCT01569243
View directory record Official record
Conditions
Type 2 Diabetes Mellitus
Interventions
Text messages, Usual care
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Remote Intervention for Diet and Exercise (RIDE)

NCT00883350
View directory record Official record
Conditions
Overweight, Obesity
Interventions
RIDE e-health application
Behavioral
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 3, 2024 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Incentivizing Lifestyle Modification to Reduce Disease Burden

NCT02945332
View directory record Official record
Conditions
Obesity, Diabetes Mellitus
Interventions
Required supervised walking, Non-required supervised walking, Fitbit Flex
Behavioral · Device
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 65 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 29, 2026, 8:14 AM EDT
Recruiting Not applicable Interventional

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

NCT06138821
View directory record Official record
Conditions
Obesity, Liver Diseases, Liver Fibrosis, Liver Fat, Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis, MASLD, MASH, Weight Loss, Insulin Resistance, Insulin Sensitivity, Insulin Sensitivity/Resistance, Metabolic Disease, Diabetes, Diabetes Mellitus, Type 2, NASH With Fibrosis, Non-Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver, Non-alcoholic Steatohepatitis
Interventions
ESG + lifestyle modification, Lifestyle modification
Device · Behavioral
Lead sponsor
Pichamol Jirapinyo, MD, MPH
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 29, 2026, 8:14 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Chia on Overweight/Obese Women

NCT03233906
View directory record Official record
Conditions
Obesity, Eating Behavior, Mood, Glucose, Dietary Modification
Interventions
Chia Seeds- Salvia Hispanica
Dietary Supplement
Lead sponsor
California State Polytechnic University, Pomona
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated May 11, 2018 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Prevention of Weight Gain in Adult Patients With Type 2 Diabetes Treated With Pioglitazone

NCT00737347
View directory record Official record
Conditions
Type 2 Diabetes, Obesity
Interventions
Lifestyle modification
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
21 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 19, 2008 · Synced Oct 29, 2026, 8:14 AM EDT
Not yet recruiting Phase 2 Interventional

Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer

NCT07820358
View directory record Official record
Conditions
Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, Endometrial Cancer Stage I, Endometrial Cancer, Fertility-Sparing Treatment (FST), Obesity & Overweight
Interventions
Semaglutide (Wegovy) weekly injection, LNG-IUD (Progestin), Structured Weight Loss Program
Drug · Device · Behavioral
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2031
U.S. locations
4
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional

A High Protein Weight Loss Intervention for Sarcopenic Obesity in Women

NCT02033655
View directory record Official record
Conditions
Weight Loss, Obesity
Interventions
Protein supplementation, Diet counseling and group education lessons
Dietary Supplement · Behavioral
Lead sponsor
Duke University
Other
Eligibility
45 Years and older · Female only
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects

NCT00856609
View directory record Official record
Conditions
Weight Loss, Obesity
Interventions
Byetta (exenatide), Weight loss, Metabolic Chamber, Placebo
Drug · Behavioral · Other
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2016
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

NCT02482571
View directory record Official record
Conditions
Brain Hypoxia
Interventions
Mild Hypoxia
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 19, 2019 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Weight Reduction Intervention for Breast Cancer Survivors

NCT00774371
View directory record Official record
Conditions
Breast Cancer
Interventions
Cognitive behavioral therapy CBT) for weight loss
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 90 Years · Female only
Enrollment
253 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Critical Periods of Exercise

NCT01041820
View directory record Official record
Conditions
Metabolism
Interventions
Exercise
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
3 Years to 7 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
2
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 25, 2019 · Synced Oct 29, 2026, 8:14 AM EDT
Completed Not applicable Interventional

Changing Healthy Outcomes In Clinic Environments

NCT00674518
View directory record Official record
Conditions
Obesity, Physical Inactivity, Diabetes
Interventions
One on one counseling, Group/team - based health education, PACE physician counseling
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
30 Years to 65 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Oct 29, 2026, 8:14 AM EDT