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Showing 1–14 of 14 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Metatarsalgia Clear all
Completed Phase 2 Interventional

A Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma)

NCT02678793
View directory record Official record
Conditions
Morton's Neuroma
Interventions
CNTX-4975
Drug
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
10
States / cities
Phoenix, Arizona • Jonesboro, Arkansas • El Cajon, California + 7 more
Source: ClinicalTrials.gov public record
Updated May 8, 2018 · Synced Jul 21, 2026, 4:49 PM EDT
Not listed Not applicable Interventional

Neuroma Injections to Treat Restless Legs Syndrome - RCT

NCT00656110
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
equal parts of 0.5% plain Marcaine and 2% lidocaine mixed with 0.8 mg Depo-medrol/4% absolute alcohol in a total injection volume of 1 ml, Normal saline - 1ml
Drug
Lead sponsor
Lowcountry Infectious Diseases
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 9, 2009 · Synced Jul 21, 2026, 4:49 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Comparison of Alcohol and Steroid Injection for Treating Morton's Neuroma

NCT00284583
View directory record Official record
Conditions
Morton's Neuroma
Interventions
Injection of Steroid into Foot, Injection of Alcohol into Foot, Injection of Lidocaine into Foot
Drug
Lead sponsor
Brown University
Other
Eligibility
18 Years to 60 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 31, 2006 · Synced Jul 21, 2026, 4:49 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma

NCT05501262
View directory record Official record
Conditions
Morton Neuroma
Interventions
Cryoablation, Nerve block
Device · Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 105 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Jul 21, 2026, 4:49 PM EDT
Not listed Not applicable Interventional

Cryoanalgesia for the Treatment of Pain in Subjects With Morton's Neuroma

NCT05604144
View directory record Official record
Conditions
Morton's Neuroma, Pain Management
Interventions
Cryoanalgesia (iovera°®)
Device
Lead sponsor
Northern California Research Trials, Inc.
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Fairfield, California • Vacaville, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Jul 21, 2026, 4:49 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Pressure Offloading Injectible System With the Use of Juvederm Voluma in the Foot

NCT04103866
View directory record Official record
Conditions
Metatarsalgia, Hyperkeratotic Callus, Corns, Fat Pad Syndrome
Interventions
Juvederm Voluma
Device
Lead sponsor
Schoenhaus, Jodi, DPM
Individual
Eligibility
40 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Jul 21, 2026, 4:49 PM EDT
Completed Not applicable Interventional Results available

Study of AxoGuard® Nerve Cap and Neurectomy for Treatment of Symptomatic Neuroma & Prevention of Recurrent Neuroma Pain

NCT03940963
View directory record Official record
Conditions
Symptomatic Neuroma, Morton's Neuroma, Chronic Nerve Pain
Interventions
AxoGuard® Nerve Cap, Standard Neurectomy
Device · Procedure
Lead sponsor
Axogen Corporation
Industry
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
11
States / cities
Los Angeles, California • Saint Augustine, Florida • Roswell, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Jul 21, 2026, 4:49 PM EDT
Completed Not applicable Interventional

Study Evaluating Treatment of Forefoot Pain Related to Nerve Entrapment Using the Cryo-Touch III Device

NCT01753778
View directory record Official record
Conditions
Entrapment Neuropathy
Interventions
Cryo-Touch III Device
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
Redwood City, California • Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2014 · Synced Jul 21, 2026, 4:49 PM EDT
Not yet recruiting Phase 2 Interventional

NAC-REPAIR for Post-surgical Pain

NCT07227649
View directory record Official record
Conditions
Carpal Tunnel Surgery, Trigger Finger Disorder, De Quervain Syndrome, Guyon's Canal, Dupuytren Contracture, Morton Neuroma, Tarsal Tunnel Syndrome, Plantar Fasciopathy, Peroneal Nerve Entrapment
Interventions
NAC, NAC 0mg/day (Placebo)
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 21, 2026, 4:49 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Compare Ultrasound Assisted Cold Therapy and Lidocaine Injection to Treat Morton's Neuroma

NCT02838758
View directory record Official record
Conditions
Intermetatarsal Neuroma
Interventions
Cryoablation, Lidocaine, Saline
Device · Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 5, 2018 · Synced Jul 21, 2026, 4:49 PM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma)

NCT02283957
View directory record Official record
Conditions
Painful Intermetatarsal Neuroma (Morton's Neuroma)
Interventions
CNTX-4975, Placebo
Drug · Other
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
16
States / cities
Phoenix, Arizona • Jonesboro, Arkansas • Castro Valley, California + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2016 · Synced Jul 21, 2026, 4:49 PM EDT
Completed No phase listed Observational

A Test of Efficacy and Foot Position Alteration in Patients Wearing Good Feet Arch Supports for the Treatment of Pain

NCT07103070
View directory record Official record
Conditions
Plantar Fasciitis of Both Feet, Metatarsalgia, Morton Neuroma, Hallux Valgus Deformity, Low Back Pain, Knee Pain, Ankle Pain
Interventions
Arch supports
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Jul 21, 2026, 4:49 PM EDT
Completed Phase 2 Interventional

ALGRX 4975 in the Treatment of Patients With Morton's Neuroma

NCT00130962
View directory record Official record
Conditions
Neuroma
Interventions
ALGRX 4975
Drug
Lead sponsor
AlgoRx Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
2
States / cities
Owings Mills, Maryland • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 2, 2005 · Synced Jul 21, 2026, 4:49 PM EDT
Completed Phase 1 Interventional

Resiniferatoxin for the Management of Refractory Morton s Neuroma Pain

NCT05695339
View directory record Official record
Conditions
Morton's Neuroma
Interventions
Resiniferatoxin
Drug
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years to 100 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 4:49 PM EDT