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ClinicalTrials.gov public records Last synced Sep 14, 2026, 4:05 AM EDT

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Showing 1–24 of 92 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Microbiome, Human Clear all
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Food DNA Digestion

NCT06687226
View directory record Official record
Conditions
Digestion Rate
Interventions
Reconstitutable food powder
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Contraceptive Hormones, Immunity, and Microbiome Evaluation

NCT03660046
View directory record Official record
Conditions
Hormonal Contraception
Interventions
Depot medroxyprogesterone acetate (DMPA), Etonogestrel implant (Eng-Implant), Levonorgestrel IUD (Lng-IUD)
Drug
Lead sponsor
Emory University
Other
Eligibility
Up to 45 Years · Female only
Enrollment
155 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 28, 2024 · Synced Sep 14, 2026, 4:05 AM EDT
Completed No phase listed Observational

Deciphering the Mechanisms Involved in Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis

NCT02400216
View directory record Official record
Conditions
Cirrhosis
Interventions
dual cholate
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Human Milk and Infant Intestinal Microbiome Study

NCT03181269
View directory record Official record
Conditions
Breast Feeding, Human Microbiome
Interventions
Intervention education, Placebo Education
Other
Lead sponsor
University of Virginia
Other
Eligibility
Not listed
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 20, 2018 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Terminalia Chebula Fruit Extract on the Gut Microbiome and Skin Biophysical Properties

NCT04597502
View directory record Official record
Conditions
Human Microbiome
Interventions
Terminalia Chebula fruit extract, Placebo, Topical Terminalia Chebula, Topical Placebo
Dietary Supplement · Other
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
25 Years to 55 Years · Female only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 14, 2022 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gut Microbiome Pill

NCT07243756
View directory record Official record
Conditions
Healthy
Interventions
3D-printed ingestible pill
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Recruiting No phase listed Observational

Optimizing Nutrition and Milk (Opti-NuM) Project

NCT06870981
View directory record Official record
Conditions
Very Low Birth Weight Baby, Early Nutrition and the Preterm Infant, Nutritional Requirements, Human Milk Fortification, Human Milk Microbiome, Human Milk Feeding, Human Milk Nutrition, Growth &Amp; Development
Interventions
Opti-NuM is an observational secondary use of data/samples study, the investigators will analyze information and specimens from the MaxiMoM platform RCTs. No interventions form part of this study.
Other
Lead sponsor
The Hospital for Sick Children
Other
Eligibility
1 Hour to 21 Days
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2027
U.S. locations
2
States / cities
Palo Alto, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Phase 4 Interventional

NICU Antibiotics and Outcomes Trial

NCT03997266
View directory record Official record
Conditions
Microbial Colonization, Extreme Prematurity, Early-Onset Neonatal Sepsis, Late-Onset Neonatal Sepsis, Necrotizing Enterocolitis of Newborn, Death; Neonatal
Interventions
Ampicillin, Gentamycin, Normal saline
Drug
Lead sponsor
Michael Morowitz
Other
Eligibility
Up to 4 Hours
Enrollment
359 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
14
States / cities
Mobile, Alabama • San Diego, California • New Haven, Connecticut + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Berries, Inflammation, and Gut Microbiome

NCT04100200
View directory record Official record
Conditions
Overweight or Obesity, Healthy
Interventions
Mixed berries, FOS, Control, Combination
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 60 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Dietary Fiber on the Gut Microbiome and HDL Particles of Human Subjects

NCT03785860
View directory record Official record
Conditions
Gut Microbiota
Interventions
Dietary Fiber, Placebo
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2021 · Synced Sep 14, 2026, 4:05 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Alternation in the Human Microbiome With Commonly Used Topical Medications

NCT03437005
View directory record Official record
Conditions
Healthy
Interventions
Desonide 0.05%, Ketoconazole 2%
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Lung HIV Microbiome Project (Michigan Site)

NCT02392182
View directory record Official record
Conditions
Healthy Participants, Tobacco Use Disorder, Human Microbiome
Interventions
Fiberoptic bronchoscopy
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 80 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Sep 14, 2026, 4:05 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

NCT06117930
View directory record Official record
Conditions
Malignant Central Nervous System Neoplasm
Interventions
Non-Interventional Study
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants

NCT07043712
View directory record Official record
Conditions
Microbial Colonization, Metabolic Syndrome
Interventions
High pulse consumption
Dietary Supplement
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
20 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Diet and Microbiome Longitudinal Monitoring With Food Intervention

NCT04758715
View directory record Official record
Conditions
Microbiome, Human, Gastrointestinal Tract
Interventions
Food provided from a commercial meal service provider for a week
Other
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
19 Years and older
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2030
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Grape Consumption on Increasing the Good Bacteria in the Human Intestine

NCT05025189
View directory record Official record
Conditions
Healthy
Interventions
Table Grape Powder, Beige Diet
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 14, 2026, 4:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sources of Bacterial Contamination in Human Milk Samples From the MiLC Trial

NCT03371511
View directory record Official record
Conditions
Bacterial Communities
Interventions
Not listed
Lead sponsor
Cornell University
Other
Eligibility
18 Years and older · Female only
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Jan 13, 2019 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Assessing the Role of a Fermented Soy Extract in Inflammation and the Human Microbiome

NCT02656056
View directory record Official record
Conditions
Obesity
Interventions
Food: (Q-Can Plus fermented soybean beverage)
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 70 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 10, 2018 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Cultures Before and After Decolonization in Community Dwelling Adults With Current S. Aureus Colonization

NCT04222699
View directory record Official record
Conditions
Human Microbiome
Interventions
Mupirocin calcium ointment, 2%, Topical Chlorhexidine, 4%
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 13, 2020 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Antimicrobial-free Production of Beef Cattle's Affect on Gut Microbiome

NCT04023604
View directory record Official record
Conditions
Diet Modification
Interventions
Controlled diet with beef raised without antibiotics, Controlled diet with beef produced in conventional systems
Other
Lead sponsor
Purdue University
Other
Eligibility
21 Years to 69 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Trimethylamine-N-oxide Production and Metabolism

NCT02558673
View directory record Official record
Conditions
Healthy
Interventions
TMAO dietary precursors, Control (or active comparator)
Other
Lead sponsor
Cornell University
Other
Eligibility
21 Years to 50 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Nov 1, 2016 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

NCT04543877
View directory record Official record
Conditions
Inflammation, Vaccine, Intestinal Permeability, Typhoid Fever
Interventions
Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine
Dietary Supplement · Biological
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 59 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Longitudinal Study of the Human Intestinal Microbiome

NCT00832286
View directory record Official record
Conditions
Dysbacteriosis
Interventions
Ciprofloxacin
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 28, 2021 · Synced Sep 14, 2026, 4:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Milk in Life Conditions (MiLC): Bacterial Composition of Human Milk Pumped and Stored in "Real-Life" Conditions

NCT03123874
View directory record Official record
Conditions
Human Milk Microbiome, Bacterial Growth
Interventions
Sterile pump set-up, Mother's Own pump set-up
Device
Lead sponsor
Cornell University
Other
Eligibility
18 Years and older · Female only
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated May 20, 2019 · Synced Sep 14, 2026, 4:05 AM EDT