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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Not applicable Interventional Accepts healthy volunteers

Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life

NCT02945371
View directory record Official record
Conditions
Smoking, Alcohol Drinking, Prescription Drug Abuse, Substance-Related Disorders, Oral Intake Reduced
Interventions
Person-centered inhibitory control training, Active behavioral response training
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
35 Years to 55 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Jul 22, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional

Rowing Following Breast Cancer Chemotherapy

NCT05848141
View directory record Official record
Conditions
Breast Cancer Survivors
Interventions
Exercise training
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 80 Years · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jul 22, 2026, 6:54 PM EDT
Completed No phase listed Observational

Perimenopause-Related Mood and Behavioral Disorders

NCT00001231
View directory record Official record
Conditions
Mood Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
40 Years to 65 Years · Female only
Enrollment
1,158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1989
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Not applicable Interventional

Heat & Aerobic Training (HEAT) Study

NCT02546726
View directory record Official record
Conditions
Pre-hypertension
Interventions
Heat & Aerobic Training (HEAT), Exercise Only
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
45 Years to 64 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Jul 22, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Western Diet on Cardiometabolic and Immune Function

NCT06528977
View directory record Official record
Conditions
Aging, Diet, Healthy
Interventions
Western Diet
Other
Lead sponsor
University of Delaware
Other
Eligibility
50 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Jul 22, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional

Mobile CBT for Middle Aged and Older Adults

NCT05754151
View directory record Official record
Conditions
Anxiety Disorders and Symptoms, Depressive Symptoms, Depression
Interventions
MAYA Mobile Application
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
40 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Not applicable Interventional

Impact of Saccharin and Acesulfame-Potassium on Glycemia

NCT07506577
View directory record Official record
Conditions
Prediabetes
Interventions
non-sugar sweetener - saccharin, non-sugar sweetener - acesulfame potassium, non-sugar sweetener - control
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Almonds on Immune Strength and Response to Flu Vaccination in Overweight Older Men and Postmenopausal Women: A Randomized Controlled Study

NCT05031663
View directory record Official record
Conditions
Immune Response, Inflammation
Interventions
Almond group, Control Group
Dietary Supplement
Lead sponsor
Loma Linda University
Other
Eligibility
40 Years to 70 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Jul 22, 2026, 6:54 PM EDT
Not yet recruiting No phase listed Observational

Exercise and Mortality in Middle-Aged and Older Adults

NCT07224659
View directory record Official record
Conditions
Overall Survival (All-cause Mortality)
Interventions
Control, Exercise
Behavioral
Lead sponsor
City of Hope Medical Center
Other
Eligibility
55 Years to 74 Years
Enrollment
19,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)

NCT04404478
View directory record Official record
Conditions
Cardiovascular Risk Factor, Stress, Self Efficacy, Depressive Symptoms, Health Behavior
Interventions
B-SWELL: Midlife Black Women's Stress Reduction Wellness Program, WE: Wellness program for Midlife Black Women
Behavioral
Lead sponsor
University of Cincinnati
Other
Eligibility
40 Years to 64 Years · Female only
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced Jul 22, 2026, 6:54 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Daily Goal Setting to Increase Everyday Physical Activity and Promote Cognitive Health in Midlife

NCT05826379
View directory record Official record
Conditions
Physical Inactivity, Walking, Cognitive Health, Self-regulation, Overweight and Obesity
Interventions
Adaptive Daily Goal Setting, Interim Goal Prompt
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
30 Years to 70 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Phase 3 Interventional

Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media

NCT02044341
View directory record Official record
Conditions
Acute Otitis Media
Interventions
AR01, Glycerin ear drops
Drug
Lead sponsor
Arbor Pharmaceuticals, Inc.
Industry
Eligibility
2 Months to 18 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
29
States / cities
Sheffield, Alabama • Tuscon, Arizona • Jonesboro, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Jul 22, 2026, 6:54 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

NCT03821623
View directory record Official record
Conditions
Hypertension, Aging
Interventions
Nicotinamide riboside, Placebo
Drug · Other
Lead sponsor
Douglas Seals
Other
Eligibility
50 Years and older
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline

NCT06466655
View directory record Official record
Conditions
Middle-aged Adults, Major Depressive Disorder
Interventions
MitoTempol, Lactated Ringer's (control)
Drug
Lead sponsor
University of Delaware
Other
Eligibility
40 Years to 55 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults

NCT03824041
View directory record Official record
Conditions
Endothelial Dysfunction, Aging
Interventions
Aronia full spectrum - half dose, Aronia full spectrum - full dose, Placebo
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
45 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Jul 22, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

NCT04248127
View directory record Official record
Conditions
Overweight
Interventions
Honey sweetened yogurt, Sugar sweetened yogurt
Other
Lead sponsor
University of California, Davis
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jul 22, 2026, 6:54 PM EDT
Completed No phase listed Observational Results available

Physical Health in Midlife: Influences of Adversity and Relationships Over Time

NCT01853332
View directory record Official record
Conditions
Cardiovascular Disease, Type 2 Diabetes
Interventions
Not listed
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
35 Years to 55 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 23, 2017 · Synced Jul 22, 2026, 6:54 PM EDT
Completed No phase listed Observational

Postprandial Lipoproteins and Atherosclerosis

NCT00005263
View directory record Official record
Conditions
Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases, Myocardial Ischemia
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1990 – 1995
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 23, 2015 · Synced Jul 22, 2026, 6:54 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Telenutrition Center: Examining the Implementation of Behavioral Therapy for Obesity

NCT03855566
View directory record Official record
Conditions
Obesity
Interventions
Intensive behavioral therapy for obesity
Behavioral
Lead sponsor
University of Southern Mississippi
Other
Eligibility
25 Years to 50 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Hattiesburg, Mississippi
Source: ClinicalTrials.gov public record
Updated Jul 17, 2023 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Not applicable Interventional

Regular Swimming, Vascular Function, and Arthritis

NCT01836380
View directory record Official record
Conditions
Osteoarthritis
Interventions
Exercise Training
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
40 Years to 90 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Jul 22, 2026, 6:54 PM EDT
Recruiting Not applicable Interventional

To Improve Depressive Symptoms Using a Web-App

NCT05405803
View directory record Official record
Conditions
Depression
Interventions
Web-App based Lifestyle Physical Activity Promotion Program, The Centers for Disease Control and Prevention (CDC) website on depression and physical activity guidelines
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
40 Years to 60 Years · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

EMPOWIR:Enhance the Metabolic Profile of Women With Insulin Resistance

NCT00618072
View directory record Official record
Conditions
Hyperinsulinemia, Insulin Resistance, Obesity
Interventions
metformin and rosiglitazone
Drug
Lead sponsor
New York Medical College
Other
Eligibility
35 Years to 55 Years · Female only
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 27, 2014 · Synced Jul 22, 2026, 6:54 PM EDT
Completed Not applicable Interventional Results available

Pain Control After Cardiac Surgery Using Intravenous Acetaminophen

NCT01822821
View directory record Official record
Conditions
Pain
Interventions
IV Acetaminophen, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 14, 2017 · Synced Jul 22, 2026, 6:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cardiovascular Effects of Incremental Diesel Exhaust Inhalation in Middle-Aged Healthy GSTM1 Null Human Volunteers

NCT01548625
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
Environmental Protection Agency (EPA)
Federal
Eligibility
50 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jul 22, 2026, 6:54 PM EDT