- Conditions
- Ear Barotrauma, Middle Ear Disease, Ear Diseases, Pressure Injury, Eustachian Tube Dysfunction, Middle Ear; Injury, Middle Ear Barotrauma
- Interventions
- Compression Profile/Schedule: 15 minute Non-Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw), Compression Profile/Schedule: 15 minute Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw)
- Procedure
- Lead sponsor
- Northwell Health
- Other
- Eligibility
- Not listed
- Enrollment
- 1,553 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2026
- U.S. locations
- 1
- States / cities
- Sleepy Hollow, New York
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- Conditions
- Middle-ear Barotrauma
- Interventions
- flight/diving simulation, ET function testing at ambient pressure, nasal video-endoscopy
- Other
- Lead sponsor
- University of Pittsburgh
- Other
- Eligibility
- 10 Years to 50 Years
- Enrollment
- 92 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2014 – 2018
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Eustachian Tube Dysfunction, Middle Ear Barotrauma, Middle Ear Disease, Middle Ear; Injury, Pressure Injury, Ear Barotrauma
- Interventions
- Hyperbaric Compression Profile
- Procedure
- Lead sponsor
- Northwell Health
- Other
- Eligibility
- Not listed
- Enrollment
- 300 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2021
- U.S. locations
- 1
- States / cities
- Sleepy Hollow, New York
- Conditions
- Barotrauma
- Interventions
- Pseudoephedrine Pill, Placebo
- Drug
- Lead sponsor
- John Muir Health
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 90 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 1
- States / cities
- Walnut Creek, California
- Conditions
- Otic Barotrauma, Pressure Injury, Ear Injury, Barotitis, Barotrauma
- Interventions
- Otic Barotrauma Grading System
- Diagnostic Test
- Lead sponsor
- Northwell Health
- Other
- Eligibility
- Not listed
- Enrollment
- 30 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2023 – 2027
- U.S. locations
- 1
- States / cities
- Sleepy Hollow, New York
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis, Tympanic Membrane Perforation, Otitis Media With Effusion, Cholesteatoma
- Interventions
- Not listed
- Lead sponsor
- VA Office of Research and Development
- Federal
- Eligibility
- 20 Years to 89 Years
- Enrollment
- 320 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2014 – 2020
- U.S. locations
- 2
- States / cities
- Portland, Oregon • Mountain Home, Tennessee