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Showing 1–24 of 46 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Middle Ear Disease Clear all
Completed Phase 3 Interventional Results available

OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement

NCT01949155
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
OTO-201, Sham
Drug
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
6 Months to 17 Years
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 10, 2016 · Synced Jun 28, 2026, 1:07 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts

NCT03297736
View directory record Official record
Conditions
Middle Ear Disease
Interventions
3D CAD/CAM autograft prosthesis, Control device
Device
Lead sponsor
Nitinetics LLC
Industry
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Jun 28, 2026, 1:07 PM EDT
Completed Not applicable Interventional Results available

Osteopathic Otitis Media Research Study

NCT00520039
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
osteopathic manipulative medicine (OMM)
Procedure
Lead sponsor
West Virginia School of Osteopathic Medicine
Other
Eligibility
6 Months to 2 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
2
States / cities
Biddeford, Maine • Lewisburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Mar 25, 2018 · Synced Jun 28, 2026, 1:07 PM EDT
Completed No phase listed Observational

Clinical Evaluation of the OtoSight

NCT03890107
View directory record Official record
Conditions
Otitis Media
Interventions
OtoSight Middle Ear Scope
Device
Lead sponsor
PhotoniCare, Inc.
Industry
Eligibility
Up to 17 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Jun 28, 2026, 1:07 PM EDT
Completed No phase listed Observational

Middle Ear Pressure Disregulation in Cleft Palate Patients

NCT00423072
View directory record Official record
Conditions
Cleft Palate
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
Up to 24 Months
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 17, 2019 · Synced Jun 28, 2026, 1:07 PM EDT
Completed Phase 2 Interventional

Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media

NCT01588535
View directory record Official record
Conditions
Pain, Otitis Media
Interventions
benzocaine, placebo
Drug
Lead sponsor
Arbor Pharmaceuticals, Inc.
Industry
Eligibility
2 Months to 4 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
15
States / cities
Jonesboro, Arkansas • Miami Beach, Florida • West Des Moines, Iowa + 11 more
Source: ClinicalTrials.gov public record
Updated May 3, 2015 · Synced Jun 28, 2026, 1:07 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Trans-Middle-Ear Mucosal Gas Exchange Project 1, Specific Aim 1

NCT01925482
View directory record Official record
Conditions
Middle Ear Gas Exchange
Interventions
6%CO2, 25%O2, balance N2, 6% CO2, 0%O2, balance N2, 20%CO2, 6%O2, balance N2, 0%CO2, 6%O2, balance N2, 6% CO2, 6%O2, balance N2, 6%CO2, 6%O2, 0%N2, balance argon
Drug
Lead sponsor
Cuneyt M. Alper
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 18, 2019 · Synced Jun 28, 2026, 1:07 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Evaluating Changes in Middle Ear Pressure Caused by CPAP

NCT02882022
View directory record Official record
Conditions
Eustachian Tube Disorder
Interventions
Continuous positive airway pressure
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older · Male only
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Jun 28, 2026, 1:07 PM EDT
Completed Phase 3 Interventional Results available

OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement

NCT01949142
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
OTO-201, Sham
Drug
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
6 Months to 17 Years
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 14, 2016 · Synced Jun 28, 2026, 1:07 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3

NCT01925495
View directory record Official record
Conditions
Middle-ear Function
Interventions
varied middle-ear pressure, varied middle-ear gas composition, varied ear-canal pressure
Other · Drug
Lead sponsor
Cuneyt M. Alper
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 16, 2019 · Synced Jun 28, 2026, 1:07 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction

NCT01974726
View directory record Official record
Conditions
Eustachian Tube Dysfunction
Interventions
ET Stress test, Sonotubometry, Forced Response Test (FRT), Inflation Deflation Test (IDT), Maneuver Sequence, 9-Step Test, Tubomanometry, Videoendoscopic assessment of ETF, Pressure chamber ET test
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 70 Years
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Jun 28, 2026, 1:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Wide Frequency Band Test of Hearing in Veterans

NCT02019888
View directory record Official record
Conditions
Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis, Tympanic Membrane Perforation, Otitis Media With Effusion, Cholesteatoma
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 89 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
2
States / cities
Portland, Oregon • Mountain Home, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced Jun 28, 2026, 1:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Eustachian Tube Growth and Development

NCT00422929
View directory record Official record
Conditions
Otitis Media
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 3 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Jun 28, 2026, 1:07 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

TransMEM Gas Exchange -- Project 1, Aim 2

NCT01925729
View directory record Official record
Conditions
Middle Ear Disease, Nasal Allergy
Interventions
ragweed, histamine, pseudoephedrine, Oxymetazoline
Biological · Drug
Lead sponsor
Cuneyt M. Alper
Other
Eligibility
18 Years to 50 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Jun 28, 2026, 1:07 PM EDT
Completed Phase 3 Interventional

Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media

NCT02044341
View directory record Official record
Conditions
Acute Otitis Media
Interventions
AR01, Glycerin ear drops
Drug
Lead sponsor
Arbor Pharmaceuticals, Inc.
Industry
Eligibility
2 Months to 18 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
29
States / cities
Sheffield, Alabama • Tuscon, Arizona • Jonesboro, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Jun 28, 2026, 1:07 PM EDT
Not yet recruiting No phase listed Observational

Evaluating Laser Otoscope for Middle Ear Effusion Detection

NCT07454512
View directory record Official record
Conditions
Middle Ear Effusion, Otitis Media
Interventions
Laser otoscope examination
Device
Lead sponsor
MSTATT LLC
Industry
Eligibility
6 Months to 18 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jun 28, 2026, 1:07 PM EDT
Completed Not applicable Interventional Results available

Benefits of the HiResolution Bionic Ear System in Adults With Asymmetric Hearing Loss

NCT02811549
View directory record Official record
Conditions
Hearing Loss, Ear Diseases, Hearing Disorders, Otorhinolaryngologic Diseases, Asymmetrical Hearing Loss, Single-Sided Deafness
Interventions
HiResolution Bionic Cochlear Implant
Device
Lead sponsor
Advanced Bionics
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Sarasota, Florida • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Jun 28, 2026, 1:07 PM EDT
Terminated Not applicable Interventional Results available

Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate

NCT03868891
View directory record Official record
Conditions
Cleft Palate, Tube Disorders Eustachian, Velopharyngeal Incompetence Due to Cleft Palate, Velopharyngeal Insufficiency
Interventions
EMST150
Device
Lead sponsor
Noel Jabbour
Other
Eligibility
6 Years to 17 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Jun 28, 2026, 1:07 PM EDT
Terminated Phase 3 Interventional

Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)

NCT02074007
View directory record Official record
Conditions
Acute Otitis Media
Interventions
AR01, Placebo Comparator
Drug
Lead sponsor
Arbor Pharmaceuticals, Inc.
Industry
Eligibility
2 Months to 18 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
21
States / cities
Phoenix, Arizona • Bakersfield, California • Fresno, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2017 · Synced Jun 28, 2026, 1:07 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Diagnostic Utility of Otosight Middle Ear Scope

NCT05641285
View directory record Official record
Conditions
Ear Infection, Middle Ear Infection, Otitis Media
Interventions
The OtoSight Middle Ear Scope
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
6 Months to 12 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Jun 28, 2026, 1:07 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c

NCT00422851
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2017 · Synced Jun 28, 2026, 1:07 PM EDT
Recruiting Not applicable Interventional

Sentence Shaping - DHH

NCT06860022
View directory record Official record
Conditions
Hearing Loss, Bilateral
Interventions
Shape Coding
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
9 Years to 15 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Jun 28, 2026, 1:07 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Vaccination for Middle Ear Infection

NCT00001605
View directory record Official record
Conditions
Otitis Media
Interventions
Nontypeable Haemophilus influenzae
Biological
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
Not listed
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 28, 2026, 1:07 PM EDT
Not yet recruiting Not applicable Interventional

SWIR Otoscopy Study

NCT06944795
View directory record Official record
Conditions
Otitis Media, Otitis Media Chronic, Otitis Media Effusion
Interventions
SWIR device
Device
Lead sponsor
Stanford University
Other
Eligibility
1 Year to 17 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Palo Alto, California • Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Jun 28, 2026, 1:07 PM EDT