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Showing 25–47 of 23 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Middle Ear Disease Clear all
Completed No phase listed Observational Accepts healthy volunteers Results available

Wide Frequency Band Test of Hearing in Veterans

NCT02019888
View directory record Official record
Conditions
Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis, Tympanic Membrane Perforation, Otitis Media With Effusion, Cholesteatoma
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 89 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2020
U.S. locations
2
States / cities
Portland, Oregon • Mountain Home, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 7, 2021 · Synced Sep 17, 2026, 4:08 AM EDT
Completed Phase 3 Interventional

Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media

NCT02044341
View directory record Official record
Conditions
Acute Otitis Media
Interventions
AR01, Glycerin ear drops
Drug
Lead sponsor
Arbor Pharmaceuticals, Inc.
Industry
Eligibility
2 Months to 18 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
29
States / cities
Sheffield, Alabama • Tuscon, Arizona • Jonesboro, Arkansas + 25 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Sep 17, 2026, 4:08 AM EDT
Completed Phase 3 Interventional Results available

OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement

NCT01949155
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
OTO-201, Sham
Drug
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
6 Months to 17 Years
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 10, 2016 · Synced Sep 17, 2026, 4:08 AM EDT
Active, not recruiting Not applicable Interventional

Posterior vs. Anterior Tympanostomy Tube Placement

NCT06191562
View directory record Official record
Conditions
Otitis Media in Children, Chronic Otitis Media With Effusion, Recurrent Acute Otitis Media
Interventions
Tympanostomy tube
Device
Lead sponsor
David Chi, MD
Other
Eligibility
6 Months to 14 Years
Enrollment
386 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Sewickley, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 17, 2026, 4:08 AM EDT
Not yet recruiting No phase listed Observational

Evaluating Laser Otoscope for Middle Ear Effusion Detection

NCT07454512
View directory record Official record
Conditions
Middle Ear Effusion, Otitis Media
Interventions
Laser otoscope examination
Device
Lead sponsor
MSTATT LLC
Industry
Eligibility
6 Months to 18 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 17, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Benefits of the HiResolution Bionic Ear System in Adults With Asymmetric Hearing Loss

NCT02811549
View directory record Official record
Conditions
Hearing Loss, Ear Diseases, Hearing Disorders, Otorhinolaryngologic Diseases, Asymmetrical Hearing Loss, Single-Sided Deafness
Interventions
HiResolution Bionic Cochlear Implant
Device
Lead sponsor
Advanced Bionics
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Sarasota, Florida • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 17, 2026, 4:08 AM EDT
Completed Not applicable Interventional Results available

Osteopathic Otitis Media Research Study

NCT00520039
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
osteopathic manipulative medicine (OMM)
Procedure
Lead sponsor
West Virginia School of Osteopathic Medicine
Other
Eligibility
6 Months to 2 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
2
States / cities
Biddeford, Maine • Lewisburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Mar 25, 2018 · Synced Sep 17, 2026, 4:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11

NCT00365092
View directory record Official record
Conditions
Otitis Media, Middle Ear Effusion
Interventions
Insertion of tympanostomy tubes
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
0 Years to 61 Days
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 16, 2006 · Synced Sep 17, 2026, 4:08 AM EDT
Recruiting Not applicable Interventional

SWIR Otoscopy Study

NCT06944795
View directory record Official record
Conditions
Otitis Media, Otitis Media Chronic, Otitis Media Effusion
Interventions
SWIR device
Device
Lead sponsor
Stanford University
Other
Eligibility
1 Year to 17 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 17, 2026, 4:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Eustachian Tube Testing in a Pressure Chamber -- Validation Study

NCT00694486
View directory record Official record
Conditions
Otitis
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Sep 17, 2026, 4:08 AM EDT
Completed Phase 3 Interventional Results available

Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays

NCT00279916
View directory record Official record
Conditions
Otitis Media, Serous, Negative Middle Ear Pressure, Rhinitis, Otitis Media With Effusion, Otitis Media, Secretory
Interventions
Triamcinolone acetonide nasal spray, Placebo nasal spray
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
6 Years to 100 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Sep 17, 2026, 4:08 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Diagnostic Utility of Otosight Middle Ear Scope

NCT05641285
View directory record Official record
Conditions
Ear Infection, Middle Ear Infection, Otitis Media
Interventions
The OtoSight Middle Ear Scope
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
6 Months to 12 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Sep 17, 2026, 4:08 AM EDT
Completed No phase listed Observational

Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion

NCT00393900
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 6 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 18, 2017 · Synced Sep 17, 2026, 4:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Genetics of Middle Ear Disease

NCT00422136
View directory record Official record
Conditions
Otitis Media
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
Not listed
Enrollment
2,121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2017 · Synced Sep 17, 2026, 4:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Eustachian Tube Growth and Development

NCT00422929
View directory record Official record
Conditions
Otitis Media
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 3 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Sep 17, 2026, 4:08 AM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3

NCT01925495
View directory record Official record
Conditions
Middle-ear Function
Interventions
varied middle-ear pressure, varied middle-ear gas composition, varied ear-canal pressure
Other · Drug
Lead sponsor
Cuneyt M. Alper
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 16, 2019 · Synced Sep 17, 2026, 4:08 AM EDT
Terminated Phase 3 Interventional

Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)

NCT02074007
View directory record Official record
Conditions
Acute Otitis Media
Interventions
AR01, Placebo Comparator
Drug
Lead sponsor
Arbor Pharmaceuticals, Inc.
Industry
Eligibility
2 Months to 18 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
21
States / cities
Phoenix, Arizona • Bakersfield, California • Fresno, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2017 · Synced Sep 17, 2026, 4:08 AM EDT
Recruiting Not applicable Interventional

Sentence Shaping - DHH

NCT06860022
View directory record Official record
Conditions
Hearing Loss, Bilateral
Interventions
Shape Coding
Behavioral
Lead sponsor
Vanderbilt University
Other
Eligibility
9 Years to 15 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 17, 2026, 4:08 AM EDT
Completed Phase 2 Interventional

Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media

NCT01588535
View directory record Official record
Conditions
Pain, Otitis Media
Interventions
benzocaine, placebo
Drug
Lead sponsor
Arbor Pharmaceuticals, Inc.
Industry
Eligibility
2 Months to 4 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
15
States / cities
Jonesboro, Arkansas • Miami Beach, Florida • West Des Moines, Iowa + 11 more
Source: ClinicalTrials.gov public record
Updated May 3, 2015 · Synced Sep 17, 2026, 4:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c

NCT00422851
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2017 · Synced Sep 17, 2026, 4:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2

NCT00694421
View directory record Official record
Conditions
Upper Respiratory Infection
Interventions
Not listed
Lead sponsor
Cuneyt M. Alper
Other
Eligibility
2 Years to 54 Years
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Sep 17, 2026, 4:08 AM EDT
Completed No phase listed Observational

Clinical Evaluation of the OtoSight

NCT03890107
View directory record Official record
Conditions
Otitis Media
Interventions
OtoSight Middle Ear Scope
Device
Lead sponsor
PhotoniCare, Inc.
Industry
Eligibility
Up to 17 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Sep 17, 2026, 4:08 AM EDT
Active, not recruiting No phase listed Observational

Utility of Advanced Ultrasound Otoscope In The Diagnosis of AOM

NCT06429709
View directory record Official record
Conditions
Otitis Media Recurrent, Middle Ear Infection, Ear Infection
Interventions
Advanced Ultrasound Otoscope
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
0 Years to 12 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 17, 2026, 4:08 AM EDT