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Showing 25–46 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Middle Ear Disease Clear all
Completed No phase listed Observational Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2

NCT00694421
View directory record Official record
Conditions
Upper Respiratory Infection
Interventions
Not listed
Lead sponsor
Cuneyt M. Alper
Other
Eligibility
2 Years to 54 Years
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Jun 28, 2026, 1:56 PM EDT
Withdrawn Not applicable Interventional

Food Allergy - Tubes - Adenoids (FATA) Trial

NCT00736112
View directory record Official record
Conditions
Otitis Media With Effusion, Food Hypersensitivity
Interventions
Food Allergy Testing, Adenoidectomy, BMT
Other · Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
Up to 4 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Jun 28, 2026, 1:56 PM EDT
Completed Not applicable Interventional

Effect of Total Compression Time and Rate (Slope) on Incidence of Symptomatic ETD and MEB: A Phase II Prospective Study.

NCT04776967
View directory record Official record
Conditions
Eustachian Tube Dysfunction, Middle Ear Barotrauma, Middle Ear Disease, Middle Ear; Injury, Pressure Injury, Ear Barotrauma
Interventions
Hyperbaric Compression Profile
Procedure
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Sleepy Hollow, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2021 · Synced Jun 28, 2026, 1:56 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Spectroscopic Evaluation of Middle Ear Infection

NCT04812093
View directory record Official record
Conditions
Middle Ear Infection
Interventions
Spectroscopic otoscope measurements
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
Up to 21 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
2
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jun 28, 2026, 1:56 PM EDT
Terminated Phase 4 Interventional Results available

Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present

NCT03655665
View directory record Official record
Conditions
Otitis Media
Interventions
Ofloxacin otic solution
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
6 Months to 10 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jun 28, 2026, 1:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Genetics of Middle Ear Disease

NCT00422136
View directory record Official record
Conditions
Otitis Media
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
Not listed
Enrollment
2,121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 13, 2017 · Synced Jun 28, 2026, 1:56 PM EDT
Completed Not applicable Interventional

Effect of Rate (Slope) of Compression on the Incidence of Symptomatic ETD and MEB: a Phase III Prospective Study.

NCT04804098
View directory record Official record
Conditions
Ear Barotrauma, Middle Ear Disease, Ear Diseases, Pressure Injury, Eustachian Tube Dysfunction, Middle Ear; Injury, Middle Ear Barotrauma
Interventions
Compression Profile/Schedule: 15 minute Non-Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw), Compression Profile/Schedule: 15 minute Linear compression from start of the daily treatment until treatment pressure is reached (45 fsw)
Procedure
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
1,553 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Sleepy Hollow, New York
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jun 28, 2026, 1:56 PM EDT
Completed Phase 2 Interventional Results available

Effect of Simethicone on Eustachian Tube Dysfunction

NCT01312038
View directory record Official record
Conditions
Otitis Media
Interventions
Simethicone, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 26, 2016 · Synced Jun 28, 2026, 1:56 PM EDT
Completed Phase 3 Interventional Results available

Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays

NCT00279916
View directory record Official record
Conditions
Otitis Media, Serous, Negative Middle Ear Pressure, Rhinitis, Otitis Media With Effusion, Otitis Media, Secretory
Interventions
Triamcinolone acetonide nasal spray, Placebo nasal spray
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
6 Years to 100 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Jun 28, 2026, 1:56 PM EDT
Terminated Not applicable Interventional Results available

Implantation of the HiRes90K™ Advantage Cochlear Implant With HiFocus™ Mid-Scala and Development of a Combined Electric and Acoustic Stimulation Technology in Adults With Partial Deafness

NCT02189798
View directory record Official record
Conditions
Hearing Loss, Partial Deafness, Hearing Disorders, Ear Diseases, Otorhinolaryngologic Diseases
Interventions
HiRes 90K™ Advantage implant with HiFocus™ Mid-Scala electrode, EAS sound processor
Device
Lead sponsor
Advanced Bionics
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
11
States / cities
Washington D.C., District of Columbia • Tampa, Florida • Lexington, Kentucky + 7 more
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Jun 28, 2026, 1:56 PM EDT
Active, not recruiting Not applicable Interventional

Posterior vs. Anterior Tympanostomy Tube Placement

NCT06191562
View directory record Official record
Conditions
Otitis Media in Children, Chronic Otitis Media With Effusion, Recurrent Acute Otitis Media
Interventions
Tympanostomy tube
Device
Lead sponsor
David Chi, MD
Other
Eligibility
6 Months to 14 Years
Enrollment
386 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Sewickley, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jun 28, 2026, 1:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11

NCT00365092
View directory record Official record
Conditions
Otitis Media, Middle Ear Effusion
Interventions
Insertion of tympanostomy tubes
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
0 Years to 61 Days
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 16, 2006 · Synced Jun 28, 2026, 1:56 PM EDT
Active, not recruiting No phase listed Observational

Utility of Advanced Ultrasound Otoscope In The Diagnosis of AOM

NCT06429709
View directory record Official record
Conditions
Otitis Media Recurrent, Middle Ear Infection, Ear Infection
Interventions
Advanced Ultrasound Otoscope
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
0 Years to 12 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Jun 28, 2026, 1:56 PM EDT
Terminated Phase 3 Interventional

Comparative Study to Evaluate the Efficacy and Safety of Telithromycin Given Once Daily Versus Cefuroxime Axetil Given Twice Daily in Children With Middle Ear Infections

NCT00174811
View directory record Official record
Conditions
Otitis Media
Interventions
telithromycin (HMR3647)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
6 Months to 59 Months
Enrollment
639 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 2, 2009 · Synced Jun 28, 2026, 1:56 PM EDT
Recruiting Not applicable Interventional

Coherent Optical Detection of Middle Ear Disease

NCT05353569
View directory record Official record
Conditions
Otitis Media, Otitis Media With Effusion, Otitis Media Acute
Interventions
OCT Device(s)
Diagnostic Test
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
12 Months to 6 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
2
States / cities
Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jun 28, 2026, 1:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3a Part ii

NCT00494364
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 40 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 12, 2017 · Synced Jun 28, 2026, 1:56 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Optical Coherence Tomography of the Middle Ear Using Ossiview

NCT05085379
View directory record Official record
Conditions
Middle Ear Disease
Interventions
Ossiview
Device
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Little Rock, AR, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 2, 2024 · Synced Jun 28, 2026, 1:56 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Diagnostic Precision and Accuracy Using the Teed Scoring System Versus the O'Neill Grading System

NCT04726306
View directory record Official record
Conditions
Otic Barotrauma, Pressure Injury, Ear Injury, Barotitis, Barotrauma
Interventions
Otic Barotrauma Grading System
Diagnostic Test
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Sleepy Hollow, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jun 28, 2026, 1:56 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Effectiveness of Over the Counter Hearing Products for Middle-Aged Adults

NCT03511417
View directory record Official record
Conditions
Hearing Loss, Functional
Interventions
over-the-counter hearing device
Device
Lead sponsor
University of Massachusetts, Amherst
Other
Eligibility
40 Years to 64 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Amherst, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 19, 2021 · Synced Jun 28, 2026, 1:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Eustachian Tube Testing in a Pressure Chamber -- Validation Study

NCT00694486
View directory record Official record
Conditions
Otitis
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Jun 28, 2026, 1:56 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Middle-ear Reflex Testing Using Wideband Acoustic Immittance

NCT04875637
View directory record Official record
Conditions
Hearing Disorders
Interventions
WAI-MEMR
Diagnostic Test
Lead sponsor
Mimosa Acoustics
Industry
Eligibility
Not listed
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Jun 28, 2026, 1:56 PM EDT
Completed No phase listed Observational

Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion

NCT00393900
View directory record Official record
Conditions
Otitis Media With Effusion
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
3 Years to 6 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 18, 2017 · Synced Jun 28, 2026, 1:56 PM EDT